fatemeh neshat

Recurrent aphthous stomatitis(RAS) is one of the most common oral mucosal injuries. Various studies have shown Contradictory and varied results about inflammatory cytokines and the biological dimensions related to this complication.This study aimed to compare salivary interleukin-2 levels in patients with recurrent aphthous stomatitis (in the active ulcerative and healing periods) and healthy people.

In this analytical and case-control study, unstimulated  saliva samples of  25 patients with recurrent aphthous stomatitis (case group) in the ulcerative and healing periods and 25 healthy individuals (control group) were collected  for assessment of interleukin-2 (IL-2) levels and transferred to the laboratory. Data were analyzed by SPSS 22 software and Independent t-test. Pvalue of lower than 0.05 was significant.

IL-2 salivary levels in  RAS patients( 114.53 ± 93.48)  pg/ml and healthy controls (112.44 ±55.185)  had significantly difference (P˂0.001). Salivary IL-2 levels in RAS subjects in active ulcerative  (114.93 ± 53.48)  and healing periods ( 110.56 ±56.71) pg/ml  no significantly difference. (P˃0.05)

According to the results of the study, salivary IL-2  levels significantly increased  in RAS people in the active ulcerative , and healing periods compared to healthy controls. However, salivary Il-2 in  the active ulcerative , and healing periods  had no changing.

Environmental tobacco smoke (ETS) is one of the most toxic environmental exposures andpassive smoking is an important general health problem. Children are the most vulnerable group to ETSexposure. This study aimed to compare the salivary total antioxidant capacity (TAC) and lipid peroxidationlevels in passive smoking and nonsmoking adolescents aged 12-15 years.

This descriptive-analytical study was conducted on 80 adolescents aged 12-15 years. The case group < br />included passive smokers and the control group comprised nonsmokers. These groups were age- andsex-matched ones. Unstimulated saliva of both groups was collected using the spitting method. Then, thesalivary total antioxidant and lipid peroxidation levels were measured using the ferric-reducing antioxidantpower (FRAP) and thiobarbituric acid reactive substances (TBARS) assays, respectively. The independentsamples t-test was used for data comparison.

There was a significant difference in salivary total antioxidant levels between the case group < br />(51.98 ± 88.97 µM) and the control group (174.35 ± 148.15 µM) (P = 0.003). There was no significantdifference between the case group (0.97 ± 1.96) and the control group (0.81 ± 0.97) in lipid peroxidationlevels (P = 0.542).

It seems that passive smoking can reduce the salivary TAC of adolescents, thereby threateningoral cavity health