gholamreza karimi

Cryptosporidiosis is a parasitic disease caused by the cryptosporidium protozoan in vertebrate animals. In livestock, especially ruminants, infants develop diarrhea syndromes. The infection is widespread throughout the world, as well as in Iran, which is reported from various species. Morphological diagnosis of Cryptosporidium species has many limitations and is of no taxonomic value alone, therefore using molecular methods helps remove these limitations to some extent. The current study is aimed at microscopic, molecular, and antigen detection and isolation of Cryptosporidium Parvum parasite. Firstly, there were 300 specimens collected from different parts of Iran. Next, purification of oocysts from feces was carried out according to the method of Casemore et al., through the flotation technique following which staining was done by means of the modified Ziehl-Neelsen method (Henriksen method), and identification through diagnostic keys. ELISA test was also performed on the specimens for which the results were from 1 positive to 4 positive. Results of our study demonstrated that from the 300 cases tested for Cryptosporidium through the molecular method, 48 cases (16%) were positive. These cases were collected during summer, autumn, and winter, however, more than 50% of positive cases were found among specimens collected in autumn. Furthermore, there were 54 positive cases found by means of PCR test, which indicates 6 cases more than that for ELISA results. Finally, results from PCR detection and ELISA, were subjected to Chi-Square analysis, where no significant difference between the collected data was observed (p=.0587).

In humanities, especially within the field of international relations, the application of theory to the analysis of events or phenomena in foreign policy and the international system is widely recognized as a salient approach. The application of theories allows us to gain a more profound understanding of the actions and reactions of countries’ foreign policies in the international system. In this line, the present study aimed to develop a model to gain a better understanding of Iran–China relations. The research sought a clearer insight into Iran–China comprehensive strategic partnership by employing a set of theories at the levels of international system, foreign policy, and domestic scene of policy formulation and decision-making. At the level of international system, it is necessary to consider the convergence between Iran and China in the context of US-led Western hegemony and counter-hegemony. At the level of foreign policy, it is crucial to consider cognitive approaches in foreign policy analysis. At the domestic level, one must take into account Iran’s prevailing economic circumstances and its challenges stemming from the US- imposed sanctions, which have prompted the Look to the East policy. China also seeks to export the surplus of its production and advance the Chinese model through partnerships. Delving into these issues, the present article investigated both theoretical considerations as well as various dimensions of Iran–China relations in practice.

Literature Review:

Rekabian et al. (2021) assert that Iran and China have actively pursued closer cooperation in regional and international organizations as a countermeasure against Western interventions. Shafiei (2022) posits that China’s comprehensive strategic partnership with Iran is primarily motivated by its own strategic objectives, while Iran engages extensively with China out of its specific needs and requirements. Corneliussen (2020) suggests that the Iran–China agreement has the potential to reshape the strategic and geopolitical dynamics in the Middle East. Figueroa (2022) highlights that Western sanctions stand as the primary hurdle to the realization of the 25-Year Iran–China Agreement and the enhancement of economic ties between the two countries. Scita (2022) argues that Washington is actively attempting to manage the contradictions arising from these roles through continuous mediation efforts. According to Loft et al. (2022), China is actively pursuing control over critical technological and industrial sectors, essential infrastructure, strategic resources, and supply chains.

The present study used a descriptive method to offer an analysis of Iran–China partnership.

The approach taken by Iran and China in establishing their comprehensive strategic partnership can be seen as a form of convergence between the two countries. China, in particular, seeks to advance its own strategic goals through these partnerships. It is also important to recognize that there are shared identity constructs between Iran and China, which can be characterized as the power of ideas evolving within the realist framework in the international system. In addition, this partnership has emerged from a nuanced understanding and recognition of the geopolitical landscape, especially within the context of the Islamic Republic of Iran. Iran is pursuing its first significant international partnership and agreement in the last century. Beyond addressing domestic needs and fulfilling economic, political, and military requirements, the Iran–China agreement is rooted in a strategic grasp of counter-hegemony as a pivotal factor in forging such agreements.

To gain a deeper insight into the Iran-China comprehensive strategic partnership, it is essential to explore various aspects and variables, ranging from domestic factors to the perceptions of their leaders, decision-makers, and policymakers, and to the dynamics of the international system. Comprehending and recognizing the positions held by the leaders of both nations within the international arena can facilitate the identification of national interests, commonalities, differences, and potential conflicts. Therefore, to enhance our understanding of the comprehensive strategic partnership between Iran and China requires an analysis of both domestic and foreign factors and variables. This approach offers valuable insights into the rationale and strategies that underlie the Iran-China partnership. The partnership is shaped not only by domestic and international circumstances but also by the perceptions of decision-makers and authorities in each country. Moreover, the resistance to a third party, such as the US, can exert a significant influence. All of these factors lead to a realist perspective in the international arena, which can contribute to more informed and effective decision-making processes for both countries involved in the comprehensive strategic partnership.

Natural coumarin called osthole is regarded as a medicinal herb with widespread applications in Traditional Chinese Medicine. It has various pharmacological properties, including antioxidant, anti-inflammatory, and anti-apoptotic effects. In some neurodegenerative diseases, osthole also shows neuroprotective properties. In this study, we explored how osthole protects human neuroblastoma SH-SY5Y cells from the cytotoxicity of 6-hydroxydopamine (6-OHDA). 

Using the MTT assay and DCFH-DA methods, respectively, the viability of the cells and the quantity of intracellular reactive oxygen species (ROS) were evaluated. Signal Transducers and Activators of Transcription (STAT), Janus Kinase (JAK), extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and caspase-3 activation levels were examined using western blotting.

In SH-SY5Y cells, the results showed that a 24-hour exposure to 6-OHDA (200 µM) lowered cell viability but markedly elevated ROS, p-JAK/JAK, p-STAT/STAT, p-ERK/ERK, p-JNK/JNK ratio, and caspase-3 levels. Interestingly, osthole (100 µM) pretreatment of cells for 24 hr prevented 6-OHDA-induced cytotoxicity by undoing all effects of 6-OHDA. 

In summary, our data showed that osthole protects SH-SY5Y cells against 6-OHDA-induced cytotoxicity by inhibiting ROS generation and reducing the activity of the JAK/STAT, MAPK, and apoptotic pathways.

With the end of the Cold War and the collapse of the Eastern Bloc, the United States gained global supremacy as a great power. But the developments in the international arena, especially the rise of emerging powers such as China, caused America to face serious challenges in the distribution of its power in the Eastern Hemisphere. China has become an influential actor in the international system and is seeking to expand its political and security influence in the world, especially in the Indo-Pacific area, by using its economic power. This issue is not acceptable for the Washington government, which has many strategic interests in this region. Therefore, the strategy of the United States to restrain China's power has appeared in the form of buck passing strategy in the Indo-Pacific region and India, among America's allies, has been able to play a role as one of Washington's main allies due to its special position in this region. This research seeks to answer the question of how India plays a role in America's buck passing strategy in the Indo-Pacific region? In response to this question that has been investigated with an explanatory-formative method and library research tools; the hypothesis and findings of the research show that the United States in order to strengthen the American buck passing was trying to build multilateral alliances with India through investment, bilateral trade, bilateral and multilateral alliances, signing military-security agreements, etc.

Changing in the concept of security occurred after the end of the Cold War, in line with developments such as beginning of the process of globalization, information and technology revolution. Changes in the structure of the international system occurred that led to the evolution of the concept of security and conceptual and theoretical developments have also taken place, from the narrow concept of security to the broader one. Thus, in today's world, the new concept includes individuals, groups, and transnational organizations that alongside governments play a role in the global arena and can be perceived in the formation of new concepts such as human security, cultural security, collective security, etc. Therefore, this study seeks the answer of this question: How has the evolution of the concept of security affected the international arena? The main hypothesis of this article is that the change in the concept of security caused that theoretical schools of international relations and security studies paid special attention to this development. The concept of security has changed and the importance of the concept of culture in world politics has increased. The study method of this research is explanatory-formative and the research data are collected on library and internet methods.

 6-Hydroxydopamine (6-OHDA) is widely used to induce neurotoxicity and investigate the mechanisms of Parkinson disease. 6-OHDA causes cell injury through various mechanisms including oxidative stress, inflammation and apoptosis. The selective Rho-kinase inhibitor, fasudil displays neuroprotective effects in several neurodegenerative disorders. The aim of this study was to assess the protective effect of fasudil in PC12 cytotoxicity induced by 6-OHDA.

 PC12 cells were exposed to 5, 10, 25, and 50 µM of fasudil concentrations. After 24 h, the IC50 value of 6-OHDA (150 µM) was added. Twenty-four hours later, the viability of cells was evaluated via MTT assay and the formation of reactive oxygen species (ROS) was measured by the fluorimetric method. At the 50 µM concentration of fasudil, with or without 6-OHDA, the changes of protein levels including STAT3, P-STAT3, JAK2, P-JAK2, and caspase-3 were determined via western blotting.

 Our results showed that 6-OHDA increased the intracellular level of ROS, reduced cell viability, upregulated p-STAT3/STAT3 and p-JAK2/JAK2 ratios and significantly raised cleaved caspase-3 in comparison to control group. Furthermore, pretreatment of cells with fasudil (50 µM) for 24 h could reverse all changes induced by 6-OHDA.

 6-OHDA caused cytotoxicity in PC12 cells through inducing oxidative stress and activating JAK/STAT and apoptosis pathways, while pretreatment with fasudil exhibited protective effect on 6-OHDA-induced neurotoxicity via the inhibition of oxidative stress and prevention of these pathways.

Recently, with the increase in diseases caused by bacterial and viral infections, the need for antibacterial agents has widely increased. On the other hand, with the development of drug resistance to organic groups of antibiotics, new antibiotics have attracted the attention of researchers because new methods are needed to reduce the activity of bacteria. Nanotechnology is increasingly being used for medical applications and is useful as an approach to kill or reduce the activity of various microorganisms. Metal oxides are considered for medical applications, especially as antibacterial agents, due to their potential advantages and suitable nanoscale properties. In this study, the electric discharge method was employed for the preparation of the iron oxide nanoparticles (IONPs) and iron-zinc oxide nanoparticles (IZONPs). As the IONPs and zinc oxide nanoparticles (ZONPs) attack various gram-positive and gram-negative bacteria by different mechanisms, it seems that the simultaneous use of these oxides can effectively kill various bacteria in outdoor and indoor media. The synthesized nanoparticles were characterized via XRD, UV-Visible, FE-SEM, EDS, HR-TEM, and TEM techniques. The obtained results showed that the IZONPs with mean particles size between 11 and 33 nanometers have successfully been synthesized in various experimental conditions. Also, the antibacterial properties of these nanoparticles were evaluated and the particles showed antibacterial properties against both gram-positive and gram-negative bacteria.

Portulaca oleracea, commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of P. oleracea in a phenylhydrazine model of anemia. Phenylhydrazine (60 mg/kg/day, i.p., two consecutive days) was used to induce anemia in rats. The aqueous and methanolic extracts of P. oleracea were prepared, and three methods of treatment were defined with two doses (500 and 750 mg/kg, i.p.). The hematological parameters and blood cell morphology, total and direct bilirubin, and morphology, and pathology of bone marrow were evaluated. The results showed that the methanolic extract has better effects than aqueous extract in improving phenylhydrazine-induced anemia. Our results showed that administration of 500 and 750 mg/kg of P. oleracea methanolic extracts for 4 days could protect against the development of anemia caused by phenylhydrazine. In summary, the methanolic extracts of P. oleracea might be effective in phenylhydrazine-induced anemia.

Messianism is one of the most important concepts in Judaism. The Zionist movement succeeded in establishing a Jewish state in the land of Palestine based on the changes it made to the traditional meaning of this concept. On the other hand, Messianism is the only common concept on which all the various Jewish sects agree. Accordingly, after the establishment of the Jewish state in 1948, Messianism entered into all aspects of Israeli domestic and foreign policies. Also, simultaneously with the Islamic Revolution in Iran, right-wing and religious groups came to power in Israel in 1977 after thirty years. One of the common traits of rightists is that they are Messianic; thus, the variable of Messianism in the foreign policy of Israel towards Iran became an objective factor and appeared in a hostile manner. Therefore, the present article uses the theory of constructivism, which in addition to material issues such as power, also considers immaterial variables such as religion to be important in international relations; it seeks to answer the question of how Jewish Messianism led Israel to pursue a hostile foreign policy toward the Islamic Republic of Iran.

Today, there is a deep belief that man, as a political animal, is motivated by emotions and internal functions of the brain and makes decisions within the framework of these emotions. From this point of view, psychology can be more effective than any other field in international relations as a window to understand politics. In the meantime, diplomacy, as the knowledge of the communication between representatives of countries and the beating heart of international politics in order to resolve disputes, needs to be equipped with psychology more than any other aspect of this field. In this regard, this article, with the aim of exploring the role and function of political psychology in diplomacy, seeks to answer the question; How and why can political psychology help diplomats in the process of diplomacy? Using the descriptive-analytical method and based on documentary studies, this hypothesis was tested that the actions of all people in the world are directed by their perceptual-personal treasury and mental expectations. Therefore, the mind as an active mirror shapes the phenomena and concepts, and the diplomat, by mastering psychology and personality cult, can reflect what he wants in this mirror to a large extent.

In this paper we use a separate production function( Cobb-Douglas) for banking industry and investigate the effect of banking sector’s performance on macroeconomic variable , like production ,interest rate spread , loan and deposit interest rate, investment, consume, employment and….. . like a lot of developing countries , who don’t have enough resources for investment, in this model we suppose that all of resources are provided by borrowing from abroad. After using  banking technology shock and tax shock on banking sector labor, the accuracy of results have proved by using Bayesian statistics including Markov chain Monte carlo  and comparison between prior and posterior distribution. In this model’s framework , a positive banking technology shock will make the borrowing from international supplier much easier and that leads to expand loan’s supply and consequently the transmission of  supply function to right side and make it possible to meet all of demands that have been have been enlarged as the result of this shock. Because this shock have raised the level of bank’s deposits too. The increasing in capital level finally leads to high level of production and employment. On the other hand the tax shock on banking sector labor will decrease the investment and consequently production and employment by falling the level of deposits and loans. The foreign interest rate Is also one of the most important  effective factors that can affect the financial and real variable of economics.

Phase Change Materials (PCMs) are currently used for many heat management applications. However, the heat transfer performance of PCMs is limited by their low thermal diffusivities. This is a critical issue for high heat flux applications, such as in the thermal management of lithium-ion (Li-ion) batteries. The present work aims the study heat transfer enhancement in a cylindrical Li-ion battery thermal management system consisting of a PCM (paraffin) loaded with randomly distributed and radially oriented carbon fibers. The system was simulated numerically under various cooling conditions, including naturally convecting air, in the presence of pure paraffin, and the presence of carbon fiber-loaded paraffin. The results for orderly arranged carbon fibers were compared with those of random distribution. Numerical results indicated that better battery thermal management can be achieved for the radially distributed carbon fiber arrangement in the PCM. The advantage of radial over random distributions can be due to the constant, uniform, and non-agglomerating distribution of carbon fibers under which thermo-physical properties of carbon fibers are better realized in the composite medium. The presence of carbon fibers with thermal conductivity of k=50W/m K in the PCM has caused more uniform temperature profiles in the radial direction because of the improved thermal conductivities. The results of this research can be used as a guideline for designing a battery thermal management system.

Saudi Arabia and Iran have long been recognized as the two main rivals in the middle east regional. But over the past years , relations between the two countries have become very complex and have taken on new dimensions. Meanwhile , one of the issues that has strained relations between the two countries in recent years is the internal developments in yemen. Therefore , the purpose of the present article is the identity and ideological confrontation between Saudi Arabia and Iran in the study of yemen. On this basis , the author seeks to answer the fundamental question of how Saudi Arabia and Iran played a role in the developments in yemen? The hypothesis that arises in response to this question is that Saudi Arabia and Iran have played a role in the developments in yemen through identity factors , This has led to a challenge between the two countries.Given the Sunni and Wahhabi identity of Saudi Arabia and its concern about the spread of Shiism and the strengthening of Iran's influence in the Persian Gulf region and ultimately the entire Middle East , the Saudi – Iranian confrontation in yemen can be explained based on a constructivism approach.

After World War II, the United States succeeded in establishing its currency, the Dollar, as the international reference currency, gaining the position of the world's leading economic and military power while leading the capitalist world. The US Dollar, according to existing metrics, still maintains its hegemonic position in the international monetary and financial system. In the new century, events such as the Euro currency supply, the 2008 financial crisis, and China's persistent efforts to internationalize its currency have gone to seriously challenge the hegemonic position of the Dollar. In this regard, the main concern of the article is to look for the factors that perpetuate the hegemony of the Dollar in the international financial and monetary system. The hypothesis tested in this regard is that the continued hegemony of the US dollar relies on the structural strength of the US in both economic and political areas and based on factors such as the depth of the capital market, ease of access to the dollar, security commitments and trust. The paper shows that the lack of these factors in relation to the Euro and the Yuan has prevented them from becoming hegemonic currencies. The findings of this study are very important for our country, which is severely facing the difficulties caused by financial sanctions due to the hegemonic position of the Dollar in the international economy today.

Potomac Horse Fever (PHF) is an acute enterocolitis syndrome causing mild colic, fever and diarrhea in all life stages in horses. It is also responsible for abortion in pregnant mares. The agent of PHF was diagnosed as Neorickettsia risticii. PHF was first diagnosed as a livestock disease, by veterinarians in Maryland State of USA in horses living around Potomac River. Since, most of the cases of disease were recorded in July, August and September, then it was regarded as a seasonal disease. Later studies revealed that a trematode vector takes the role as a vector for transmission. Routine cell culture and PCR were used for clinical diagnosis of the PHF. Using indirect fluorescent antibody tests revealed positive cases in most places of Canada and America, which regarded as former contacts with the agent of disease. Neorickettsia risticii could not be seen in monocyte in prepared blood smears from clinical cases of horses and this is contrary to Anaplasma phagocytophilum which very easily seen in granulocytes of blood in infected horses. Neorickettsia risticii has been isolated from released trematodes from fresh water snails. PHF is not a contagious disease and infected horses could be kept near susceptible horses. PHF is not regarded as a zoonosis. It is concluded that related veterinarians to horse industry in Iran should be informed about the possible occurrence of disease.

Unearthing the immune defects associated genes and genetic variations may lead to locating novel targetable elements and introducing the underlying mechanisms and pathways of the desired condition. The major histocompatibility complex (MHC) genes are essential for protein antigens presentation and inducing immune response as well as are associated with production and phenotypic traits. The MHC class II genes of cattle and buffaloes, Bovine Leukocyte Antigen (BoLA) or Buffalo Leukocyte Antigen (BuLA), are located on the short arm of chromosome 23. It has been demonstrated that the second exon of BoLA-DRB3 (BoLA-DRB3.2) is highly polymorphic, having more than one hundred identified alleles, that each of them can form special binding pockets for corresponding antigenic peptides. Concerning the populations of cows, unique native and hybrid, and buffaloes are distinctly divided into different regions of Iran, analysis and interpretation of the polymorphisms’ expression status of this locus can be implemented to find better breeding strategies like selecting highly resistant animals to infection diseases, in herds. It also can help to develop effective and novel vaccines regarding allele frequencies in populations; different allelic variants of MHC class II binding to different peptides. Immunogenic evaluation of animals’ genome/genes characteristics has always been used as a model for the study of similar genes in humans.

Aluminium phosphide is used worldwide as a rodenticide and fumigant against sorted grain. Accidental or intentional exposure to aluminium phosphide (determined as PH3) results in extreme toxic effects on human. Due to the lack of a specific antidote, management of PH3 poisoning remains supportive and symptomatic. Curcumin, the main compounds of turmeric, has been reported to possess strong antioxidant and anti-apoptotic properties. This study was conducted to evaluate the effect of nanocurcumin on PH3 toxicity in HepG2 cell line.  For this study, the cells pretreated with nanocurcumin (nCUR) and then exposed to PH3 for 6 hr. The cytotoxic and apoptotic effects of PH3 and nCUR were evaluated by MTT and propidium iodide flow cytometry. Indeed, the level of reactive oxygen species and glutathione were determined by fluorometric and colorimetric method. The oxidative DNA damage (8-OHdG) marker was also measured by ELISA kit.  Pretreatment with nCUR elevated the cell viability in PH3-treated cells and antagonized the PH3-induced glutathione depletion at high doses. Indeed, a significant decrease in the level of ROS and 8-OHdG as well as apoptotic activities were observed following exposure to nCUR. These results indicated that nCUR could protect HepG2 cells against PH3 induced cell injury by attenuation of ROS and increasing GSH level. The nCUR efficiently suppressed increased apoptosis activity and formation of 8-OHdG and ultimately improved cell viability. Therefore, nCUR can be considered as promising therapeutic agents in treatment of aluminium phosphide poisoning.

Saudi Arabia's aggressive regional policies toward Iran from 2003 to 2020AbstractThe present study examines Saudi Arabia's aggressive regional policies toward Iran from 2003 to 2020.Saudi Arabia,known before 2003 as a conservative state in the region, has changed its regional policy since 2003,confronting Iran. But the main question of the research is why Saudi Arabia has adopted an aggressive policy towards Iran in the region? In response, it can be said that Saudi Arabia has pursued an aggressive policy against the power and influence of Iran following the developments in the region since 2003 and considering itself as a regional hegemon and leader of the Arab word. Saudi Arabia has also entered into military and arms deals with the United States in response to Iran's nuclear talk,to prevent Iranian influence in the region.The present study is written in the framework of aggressive realism theory and using descriptive-analytical method using library and internet data.Keyword:Saudi Arabia, Iran, region, realism theory

The world of diplomacy is witnessing the introduction of new tools for diplomatic engagement. In other words, the introduction of technology, especially mass media technologies such as Twitter, has introduced a new type of diplomatic process. Twitter has become a scene of attack, criticism, and commentary by activists and politicians on a variety of political and global issues that have interactive effects. This type of diplomacy was developed by the name of "Twiplomacy" that by the beginning of the year, 193 UN member states had used this type of diplomatic process. That is, the politicians of the countries had a Twitter account. To this end, this study examines the Twitter diplomacy of the Trump presidency. The key question is how and with what narrative does Trump present his diplomacy on Twitter? To answer the research questions and achieve the desired goals, digital content analysis and discourse analysis with two techniques of categories and evaluation were used. The statistical population of this study is the sum of the tweets of the US President (Trump) Twitter pages in 2017-2019.

Metabolic syndrome (MetS), as a health-threatening factor, consists of various symptoms including insulin resistance, high blood sugar, hypertension, dyslipidemia, inflammation, and abdominal obesity that raise the risk of diabetes mellitus and cardiovascular disease. Cardiovascular diseases are important causes of mortality among the world population. Recently, there has been a growing interest in using phytomedicine and natural compounds in the prevention and treatment of various diseases. The data was gathered by searching various standard electronic databases (Google Scholar, Scopus, Web of Science, and PubMed) for English articles with no time limitations. All in vivo, in vitro, and clinical studies were included. Elettaria cardamomum (cardamom) is a rich source of phenolic compounds, volatile oils, and fixed oils. Cardamom and its pharmacologically effective substances have shown broad-spectrum activities including antihypertensive, anti-oxidant, lipid-modifying, anti-inflammatory, anti-atherosclerotic, anti-thrombotic, hepatoprotective, hypocholesterolemic, anti-obesity, and antidiabetic effects. This review aims to highlight the therapeutic effects of cardamom on MetS and its components including diabetes, hyperlipidemia, obesity, and high blood pressure as well as the underlying mechanisms in the management of MetS. Finally, it can be stated that cardamom has beneficial effects on the treatment of MetS and its complications.

Osteoarthritis (OA) is the most common disease of joints caused by degradation of articular cartilage and subchondral bone. It is unknown whether different therapy exert differential cellular effects. On the other hand, Since OA may be associated with CVD and decrease Telomeres length. Telomeres protect chromosome ends and Integral for the maintenance of telomeres is the protein complex Shelterin. In this study, the effects of ozone (O3) and aerobic training were considered on Shelterin expression proteins in heart rats with knee OA. In this experimental study, knee OA was induced by surgical method in rats. Fifteen male Wistar rats were randomly divided into three groups: knee OA control group (OA); OA plus exercise group (OAE) and OA plus O3 group (OAO). The aerobic training (treadmill; 16 m/min;50 min/day) started 4 weeks after the surgery, 3 days/week for 8 weeks. Rats in the OAO group received O3 at the concentration of 20μg/ml, once weekly for 3 weeks. 48 hours after the programs, cartilage and heart tissues were isolated and expression of RAP1, TIN2 and TPP1 were considered using Western Blot. In OAE significantly increased the expression of RAP1 compared to the OA and OAO groups. But not difference between OA and OAO groups. In OAE group had significantly higher expression of TIN2 compared to the OAO and OAE, and no difference between OAE and OAO groups. Also, there was no significant difference in the expression of TPP1 and between three groups. Aerobic Exercise improved cardiac Shelterin proteins expression in OA rats, rather than the Ozone therapy groups.

Although LCS, as the most important form of payment in foreign trade, has significantly covered the risk of transactions for buyers or creditors, it has not been able to free the process of payment of goods in international trade contracts without any risk. . The practice of LCs in the light of the legal principles governing LCs, the most important of which is the independence of LCs from the basic transaction and the principle of absolute acceptance of documents, can pose numerous risks to buyers that, if fulfilled, It will significantly affect their interests. Therefore, in this paper, the authors, while analyzing the types of risks involved in LCs for sellers and exploring how they are implemented, have outlined ways to prevent or at least reduce their probability by considering the principles of LCs. The material presented in this article shows that buyers should consider the risks that could seriously affect their trading interests in the process of credit accreditation, and implement various enforcement strategies to safeguard their contractual interests. To consider.

Calf scours (diarrhea) in unweaned calves play a major role in economic losses of animal farming industry worldwide. The present study was conducted to investigate and interpret the presence of BRV, BVDV, and Escherichia coli K99 by molecular and serological approaches simultaneously.

A total of 73 E. coli-negative diarrheic fecal samples were collected from one-week to less than one-month-old calves of Holstein dairy cattle herds of some provinces of Iran during autumn and winter. The samples were directed to antigen detection by ELISA (Enzyme Linked ImmunoSorbent Assay), RNA extraction by semi-manual approach, and cDNA synthesis for PCR amplification.

Out of 73 calves’ diarrheic  fecal samples, 28 (38.3%) and 1 (1.36%) were positive for BRV and BVDR by ELISA, respectively. However, 31 (42.4%) samples were positive for BRV and non for BVDV by RT-PCR. The Kappa coefficient showed significant differences in BRV and BVDR detection between ELISA and RT-PCR methods. The distribution of the BRV-positive samples among bovine diarrheic calves was 80, 52.6, and 50% in Eslamshahr, Qazvin, and Hamedan, respectively.

ELISA and RT-PCR indicated high prevalence rate of BRV in autumn and winter, respectively. The present study results showed that positive cases detected by RT-PCR were more than those detected by ELISA. Further studies are needed to achieve a comprehensive preventive and therapeutic strategy to address  diarrhea bovine pathogens.

The Mashhad drug and poison information center (MDPIC) was officially established in 2000 to provide up-to-date information on medications. The objective of this study is to provide an epidemiologic profile of drug inquiry and poisoning-related phone calls to MDPIC from 2007 to 2017. This article is a descriptive retrospective study in which all inquiries about drugs and poisoning cases received by MDPIC, from 1st January 2007 to 31st December 2017, were retrieved from its database for analysis. A total of 100997 cases were analyzed. The most frequent calls were from individuals in the age group of 18 to 60 years old (70.21%). The majority of callers were women (73.08%). The public made 95.11% of calls, and 4.89% were related to health care professionals. The queries were mainly related to therapeutic uses of drugs (24.03%), followed by adverse drug reactions (18.96%). Given that 99.23% of calls were related to drug information inquiries, the most common drugs questioned about were antimicrobial (12.3%) and vitamin and minerals (10.76%), whereas 0.77% of calls were about poisoning and the majority of them were due to drugs poisoning. Micromedex® was the most commonly used reference to answer the inquiries. This report shows an updated epidemiological evaluation on recorded calls in the drug and poison information center in Mashhad. Since there is no other similar report, this can provide valuable information on the trend of drug usage and may guide further strategies in giving proper information to public and health centers.