h. matin homaee

The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and consumption of l-carnitine on some of the oxidative stress factors in diabetic kidney.
 

In the present experimental study, 45 male Wistar rats(200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving l-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving l-carnitine. Rats were diabetic peritoneal injected with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily of 100 mg of l-carnitine orally. The aerobic exercise protocol included five sessions per week on the treadmill. Data were analyzed by two way ANOVA and Tukey post hoc test at P <0.05.
 

Six weeks of aerobic exercise, supplementation of  l-carnitine and combined intervention of aerobic exercise and supplementation of l-carnitine do not have a significant effect on MDA and SOD  factors of kidney  tissue in diabetic rats(p>0.05). However, six weeks of aerobic exercise had a significant effect on GPX factor in kidney tissue in diabetic rats (p=0.003). Moreover, supplementation   and combined intervention of aerobic exercise and supplementation of l-carnitine did not have a significant effect on GPX factor of kidney tissue in diabetic rats (p>0.05)
 

L-carnitine supplementation intake with regular exercise can have beneficial effects on the body, antioxidant defense system and decreases oxidative stress in rats with type 2 diabetes.

Although obesity is becoming epidemic all around the world, the effort to reduce its prevalence has not been effective. Thus, there is a need to find further paths to prevent obesity. The aim of this study was to determine the effect of endurance training and adenosine on the A1AR gene expression in the visceral adipose tissue of obese male rats Twenty wistar strain male rats were fed with high-fat food for twelve weeks and reached the average weight of 319+-30 grams. The rats were divided randomly into four groups after being conformed. The exercise training session included running on the treadmill with no slope for 12 week. Each week, five sessions were held for 15-31 minutes with the speed of 20-25 meters per minute. In order to measure the relative gene expression of A1AR, the PCR method was used. The data was analyzed using the statistical method of two-way analysis of variance. both variable of endurance training and adenosine consumption (independently) demonstrated a significant decrease in the A1AR gene expression in the visceral adipose tissue. (P=0.001). Also, the intraction of training and adenosine affects significant reduction of the A1AR expression. Endurance training and adenosine are strong stimulants of adipose tissue lipolysis as A1AR antagonists and have the potential to be used as effective lipolysis agents in obesity

Physical activities and increased physical fitness have always been recognized as a possible factor in the reduction of diseases and the related mortality. The telomere length is considered as a major cell age biomarker and is connected with diseases. The current study was conducted aimed at examining the effects of an 8-week resistance-interval training on the telomere length, telomerase activity, and TRF2 expression in sedentary young men.

In a semi-experimental experiment, 20 sedentary male students from the Islamic Azad University of Eslamshahr were selected and randomly assigned to the two groups of training (N=10) and control (N=10). The training protocol consisted of the concurrent interval and resistance trainings, with each session consisted of two steps. The first step was an interval training consisted of running on a treadmill, and the second one was related to a resistance training that was performed. Blood samples were taken half an hour before the first exercise and 24 hours after the last exercise, with 10 ml of blood taken from the brachial vein of each subject. Independent and dependent t-tests were used for the data analysis.

The findings of present study demonstrated that an 8-week resistance-interval training prevented the telomere length shortening (t=3.87, p=0.022) and increased the telomerase activity (t=5.107, p=0.000). In addition, TRF2 levels (t=2.463.87, p=0.014) increased significantly compared to the pre-exercise condition.

The concurrent exercises increased the telomere length and telomerase activity of the subjects significantly. It seems that the exercises can have a favorable effect on telomere biology and the quality of life. The results indicated the importance of regular physical activities and consequently the reduced risk of diseases associated with aging.