hadi kardan

Asprosin is an adipokine related to glucose homeostasis and type 2 diabetes (T2D). It has also been stated that exercise is one of the main pillars in the management of T2D, along with drug therapy. The aim of this study was to determine the effect of a short period of aerobic exercise on serum asprosin, glycemic control, and lipid profile in women with T2D.

In this semi-experimental study, 30 women with T2D from Zabol were selected by purposive sampling and divided into the training (3 weeks of aerobic exercises, 3 sessions per week) and control (no training) groups. Fasting blood sugar (FBS), fructosamine, asprosin, and lipid profiles were measured at the beginning of the intervention and 48 hours after the last session of the intervention.

The findings of the present study showed that after 3 weeks of intervention, there was a significant decrease in FBS (P=0.011), fructosamine (P<0.001), and serum asprosin (P=0.038) and a significant increase in the high-density lipoprotein level (P=0.002) in the training group compared to the control group. However, no significant difference was observed in triglyceride, total cholesterol, or low-density lipoprotein (P>0.05).

Based on the findings, 3 weeks of aerobic training had positive effects on the adjustment of serum asprosin, which was related to glycemic control and the improvement of the lipid profile.

Introduction: Exercise and the use of herbal supplements are among the therapeutic interventions in controlling type 2 diabetes. This study aimed to compare the effect of exercise and karela supplement on glycemic control and metabolic complications in patients with type 2 diabetes. Methods: In the present quasi-experimental study, 120 patients with type 2 diabetes were selected by purposive sampling and were randomly divided into 4 groups of exercise, karela supplement, combined, and control. Exercises included 8-week pyramid aerobic training, 3 sessions per week. Karela was consumed in a dose of 50 mg/kg body weight daily in form of karela powder. Results: There was a significant decrease in fasting blood sugar (FBS), 2-hour postprandial glucose (2hPP), insulin resistance, and glycated hemoglobin (HbA1c) in the intervention groups compared to the control group (P < 0.001). Further, there was no significant difference between changes in FBS in the intervention groups (P < 0.05), but 2hPP, insulin resistance, and HbA1c were higher in the training and combined groups compared to supplement group (P < 0.001); however, there was no difference between the two groups (P > 0.05). Conclusion: According to the results, it can be said that both methods of exercise and karela consumption have a positive effect on glycemic control in type 2 diabetes, but interventions and the combination of exercise and the supplement are more effective in glycemic control than karela alone.