The Effect of a Short Period of Aerobic Training on Serum Asprosin, Glycemic Control, and Lipid Profile in Women with Type 2 Diabetes

Asprosin is an adipokine related to glucose homeostasis and type 2 diabetes (T2D). It has also been stated that exercise is one of the main pillars in the management of T2D, along with drug therapy. The aim of this study was to determine the effect of a short period of aerobic exercise on serum asprosin, glycemic control, and lipid profile in women with T2D.

In this semi-experimental study, 30 women with T2D from Zabol were selected by purposive sampling and divided into the training (3 weeks of aerobic exercises, 3 sessions per week) and control (no training) groups. Fasting blood sugar (FBS), fructosamine, asprosin, and lipid profiles were measured at the beginning of the intervention and 48 hours after the last session of the intervention.

The findings of the present study showed that after 3 weeks of intervention, there was a significant decrease in FBS (P=0.011), fructosamine (P<0.001), and serum asprosin (P=0.038) and a significant increase in the high-density lipoprotein level (P=0.002) in the training group compared to the control group. However, no significant difference was observed in triglyceride, total cholesterol, or low-density lipoprotein (P>0.05).

Based on the findings, 3 weeks of aerobic training had positive effects on the adjustment of serum asprosin, which was related to glycemic control and the improvement of the lipid profile.