hamed mohammadi

Since the 2010s, the production of movies and series based on home cinema has emerged in our country. Since the representation of women in media such as home cinema is effective on the attitude of the audience as well the society, it is important to address the way women are represented in home cinema. One of the representations of the media considering women's issues is observable in Shahrezad series; therefore, the authors in this study have analyzed the representation of women in three seasons of the Shahrezad series by applying narrative analysis as well as problem solving approach. Coding at three levels led the authors to five themes at the third level, eighteen concepts at the second level, and 124 categories at the first level. The findings indicate that while paying attention to the position of women, the representation of women and their gender identity in Shahrazad series shows their cognitive-behavioral algorithm during the second Pahlavi period as a symbol of the confrontation between tradition and modernity. This means that women in the foresaid era were acting in a subordinate position in the private domain and were dependent on men; however, as highlighted in the second season of the series, they were trying to gain a social status in the public arena. Meanwhile, it can be seen that the aristocracy system was able to affect the public and private roles of people. In general, women's encounter with modernity in Iran was experienced with the perception of modernity in its general entirety, and the specific functions of tradition had lost its balance, and the impact of modernity has brought many consequences for them.

Iran's oil industry plays a strategic role in the country's economy in the field of selling oil and gas and their products and providing domestic and foreign financial resources, and in this regard, it has serious challenges in the processes of doing work, which can be considered as one of the instance of this industry facing the phenomenon of corruption and since Iran's economy is a single product based on the sale of oil and gas, the occurrence of corruption in this industry will always be conceivable. This study was conducted with the aim of preventing corruption by identifying corruption points with a process approach based on risk management in one of the subsidiaries of Iran's gas industry.

The research method was a mixed type and combination of qualitative and quantitative methods, and in the qualitative part, to count the points of corruption, while examining the main and secondary processes of each management and Staff unit, using the interview tool, and in the quantitative part, the risk management approach based on a questionnaire used.

Based on the findings of the research, 58 points were in the low-risk range (green area), 63 points were in the medium risk range (yellow area) and 7 points were in the high-risk range (red area).

The findings can help the studied organization to control corruption points as a driver for improving the integrity of the administrative system, and this is possible through a review of the financial, administrative, legal and gas supply processes.

Five-year development plans determine the path of growth and development of our country in economic, social and cultural dimensions. These programs are compiled based on the constitution, the country's 20-year vision document and general policies announced by the Supreme Leader. Due to the important and valuable position of women in society, in all programs, there are provisions dedicated to women's issues in all cultural, social and economic dimensions. Although some of these provisions are useful, they are not enough for this area. The Seventh Development Plan Bill is not an exception to this rule and, despite the good points raised in it, it also faces shortcomings. In this article, the method of categorical content analysis has been used, and the previous development programs have been reviewed, and it has been tried to analyze the materials and clauses mentioned in chapter 16 of the seventh development program, which is dedicated to women, family and the population. To improve and complete the mentioned materials, provide tips, criticisms and suggestions. In this program, we have positive and better points regarding the status of women and family than in previous development programs, still the general evaluation of the proposed rulings in the field of women, family and the young people of the population shows the lack of comprehensiveness in problem analysis and the lack of discourse consensus in it has the field of women and family. So, it has been tried to provide corrective rulings in accordance with each section and the identified challenges

Since humans entered this material world, the question has arisen in their minds: what is life, and why and how should one live it? If a person can answer this question well, the path of life becomes clear to them; otherwise, they may lose their way and fall prey to deviant ideologies such as nihilism. In this article, the views of Professor Asghar Taherzadeh on nihilism have been collected from his works. The importance of the discussion lies in understanding the reasons for reaching nihilistic thoughts. In such a case, if a person knows the cause, they can address it; otherwise, they distract themselves and become engaged in other things, seeking refuge from one problem to another, neglecting inner pain and its proper treatment. For this reason, to properly address it, we must understand the roots of nihilism and anxieties. This article has been compiled in a domestic format and attempts to present Professor Taherzadeh›s views on this subject, the author not critiquing the professor›s opinion. In this paper, topics such as self-awareness, materialism, and secularism are examined, with an emphasis on Professor Taherzadeh›s perspective. In general, it can be said that the main reason for nihilism in humans is the lack of self-awareness and lack of belief in God.

Background and Heavy metals are among the most critical contaminants in drinking water, owing to their stability and accumulation capability in living tissues and the food chain. Consequently, this study was conducted to determine the carcinogenic and non-carcinogenic risk assessment indices for heavy metals in the water sources of Torbat-e Jam City in 2023. Samples were collected from 16 groundwater sources and the surrounding soil of Torbat-e Jam City during the summer and autumn of 2023. Concentrations of five heavy metals - arsenic, mercury, lead, cadmium, and copper - were measured using a Varian atomic absorption spectrometer. Finally, the health risk levels for three different groups were calculated using indices provided by the Environmental Protection Agency (EPA) of the United States. The average concentrations of heavy metals in water during summer were as follows: arsenic: 0.0027 ± 0.0035 mg/L, mercury: 0.00019 ± 0.00035 mg/L, lead: 0.0011 ± 0.0023 mg/L, cadmium: 0.0002 ± 0.0002 mg/L, and copper: 0.0046 ± 0.0078 mg/L. In autumn, the concentrations were arsenic: 0.0082 ± 0.0081 mg/L, mercury: 0.0018 ± 0.0008 mg/L, lead: 0.0056 ± 0.0058 mg/L, cadmium: 0.00084 ± 0.00083 mg/L, and copper: 0.0091 ± 0.0068 mg/L. In soil, the concentrations were arsenic: 0.011 ± 0.053 mg/L, mercury: 0.0086 ± 0.0068 mg/L, lead: 0.131 ± 0.186 mg/L, cadmium: 0.0002 ± 0.00047 mg/L, and copper: 0.12 ± 0.24 mg/L. The study found the non-carcinogenic risk levels of the examined heavy metals to be low. However, the carcinogenic risk level for arsenic was very high in both seasons, for cadmium was moderate in autumn, and for the other elements, it was within the standard limits. Given the high carcinogenic risk of arsenic for women, men, and children in both summer and autumn, continuous monitoring of arsenic levels should be a priority for regulatory agencies.

Leakage is one of the main problems of urban water distribution networks. Leakage control and management can play an important role in increasing network efficiency and reducing water loss. Pressure reduction in water distribution networks is usually done using Pressure reducing valve (PRV), while the energy dissipated from head loss can be recovered to generate hydropower. In this study, the possibility of using pump as turbines (PATs) instead of PRVs in a water distribution network has been investigated. Regarding this purpose, the genetic algorithm is used by MATLAB software, in which the hydraulic model of the water distribution network is carried out in WaterGEMS software. At first, the aim of optimization is to determine the optimum output of PRVs. Then after replacing the PRVs with the PATs, the optimal curve for the PATs can be determined. Results show that the use of PATs to control the pressure is effective, so that compared to the basic model, the leakage rate has decreased by about 33% and the Nodal Pressure Reliability Index (NPRI) has increased by 0.41. Moreover, the nodal pressures have been significantly reduced, and the average pressure of the network decreased by 58%.

PerposeThe aim of the current research is to provide a new conceptual framework for competency-based training of organizational employees, which, based on studies conducted in scientific sources, has become evident that no systematic literature review has been conducted in this field to date.MethodThis research was carried out using the Meta-synthesis method on 714 internal and external articles and related sources from 2010 to 2023. ResultsThe findings of the articles were analyzed using the seven-step method of Sandolowski and Barso. The results obtained from 41 selected articles based on 95 concepts, 16 Main themes, and 4 Sub thems; in the dimensions of competency-oriented needs assessment (supply-oriented approach, demand-oriented approach, evidence-oriented approach); - competency based design (program order, program content, program references); competency -based implementation (intra-organizational training, extra-organizational training, virtual training); And competency -based evaluation (knowledge evaluation, skill evaluation, behavioral evaluation) was examined and analyzed.ConclusionCompetency-based training allows people to improve their skills and competencies and develop them in a practical way. In general, it can be concluded that this approach can help people and organizations to improve performance, increase capabilities, and accelerate the achievement of their real goals. This type of training contributes to the productivity and effectiveness of development.

Paying attention to the dimension of values and their effect on choices, implementation, and monitoring in the public policymaking process leads researchers to consider the role of ideologies in this process. The examination of ideology under the concept of ideas/values in the policymaking process has been growing in recent centuries due to the effects of extreme ideological currents on public policies and their consequences. However, due to the complexity and need for suitable practical tools, public administration researchers have been kept from addressing it. In this regard, in this research, while focusing on which comprehensive value system affects the public policies in the field of higher education in Iran, the authors study the theory-oriented system about the role of ideology in public policy making. Finally, they presented two analytical frameworks to organize the influencing factors of ideology in public policies in Iran in general and in the field of higher education in particular. While obtaining the opinion of a group of experts in this field, they revised and completed it using the Delphi method. The main advantage of these two frameworks is the appropriate summarization of the main dimensions of the concept of ideology and its application in policymaking, which can be used for analytical purposes in the field of public policies. Research in the field of ideology in policymaking using these tools can guide future research while providing a practical tool for researchers and policymakers who wish to reduce the adverse effects of ideology and strengthen its alternatives.

Development as a multi-dimensional concept has always been the focus of policymakers and government agents and in many studies, only the economic dimension of development was focused on, but in the present study, in addition to the economic dimension, attention was also paid to the political and social dimensions of development in Iran, and in In this regard, the first volume of the "80 Years of Information" series from the publications of the Information Institute was used, in which the political, economic and social events of the Iranian society in the period of 1925-1978 were mentioned.

The research method is of a qualitative type, which falls under the category of interpretive research, and thematic analysis method was used to analyze the data obtained from the text of the book.

The number of 16, 31 and 33 concepts for the political, economic and social dimensions of development were counted from the text of the book, and the number of 9, 13 and 16 main, organizing and comprehensive themes were assigned to the political, economic and social dimensions of development in Iran respectively and the researcher Paying attention to his mental images, he drew the relationships between themes in the form of a network of development themes.

Iran has enjoyed significant progress in the social, economic and political fields during the studied period, while the government planning system in this era has brought multiple contradictions such as the government's control and influence in the economic, political and social sectors.

The present study aimed to investigate the level of structural safety and resistance of comprehensive health service centers, which provide critical services during earthquakes. For this purpose, a total of 30 comprehensive rural health centers and 14 comprehensive urban health centers in Babol city were examined.

To assess the cultural safety and resilience of comprehensive health service centers in Babol city against earthquakes, we integrated two questionnaires, one from the research of Pourahmad et al. (2018) and the other from the Ministry of Health and Medicine, both of which have been confirmed for validity and reliability. Using these questionnaires, we obtained 9 structural safety indicators and applied this questionnaire to all 44 health units in the city. The data were analyzed using SPSS. 20 software. Additionally, we used the Vicor software to evaluate, score, and rank the physical resilience of comprehensive health service centers against earthquakes.

The total area of the evaluated structures in this research was 18, 340 m2, with construction dates ranging from 1968 to 2019. The physical resilience of all comprehensive health service centers in Babol city in 2021 was the following results 18.2% were categorized as favorable, 18.2% as relatively favorable, 15.9% as average, 20.5% as relatively unfavorable, and 27.3% as unfavorable.

In the face of disasters and earthquakes, the health and safety of society depend on the infrastructure and resilience of critical service centers, such as comprehensive health service centers. Upgrading the infrastructure of these centers is crucial to ensure their resilience and protect the health and safety of society. The investigation of comprehensive health service centers in Babol city reveals that more than half of the structures are over 30 years old and lack sufficient resilience against natural disasters. Therefore, investments are needed to improve the physical resilience of these centers. Strategies such as structural reinforcement, regular maintenance, and the implementation of safety standards can enhance their resilience and help them better cope with earthquakes.

Today, accidents in the oil and gas industry have increased all over the world, and therefore, paying attention to the health and safety of employees as well as improving ergonomic and human conditions in the workplace has become a necessity in the oil and gas industry. In the present article, a general question about the categories affecting human conditions and ergonomics in Iran's gas transmission industry was investigated.

In order to investigate the issue, an exploratory study was conducted and the data was collected using a qualitative research method based on unstructured interviews and three-stage coding process to determine categories that are effective in conditions and ergonomics and human were used and then the paradigm model of the research was explained.

A number of 20 open coding extracted from the transcript of the interviews were obtained and then by classifying the concepts that had a common semantic load, 7 sub-categories and 4 main categories were assigned to the concept of the present research, and then the paradigm model was explained in 5 categories of causal, central, strategic, Mediation, and consequences.

The realization of the mission and goals of Iran Gas Transmission Company depends on the existence of a safe work environment and improvement of human relations in the work environment, and in this regard, effective measures should be taken in the field of human resources management and improvement of the level of mental and physical health of employees and ergonomics of the work environment.

The main goal of the research is to improve the health of the administrative system by identifying corruption points in one of the affiliated regions of Iran Gas Transmission. The research is applied research in terms of its purpose, descriptive research in terms of data collection and a mixed type in terms of method. The study is qualitative in that the interview method was used to identify corruption points and the quantitative sense it was used to analyze the data using the dimtel method. Findings of the research identified 19 points of corruption in the qualitative part and in the quantitative part among points of corruption, 13 points were determined as causal points and six points as disabled points. The results indicate that the identification of corruption points can be used as drivers of improving the health of the administrative system and the main step to control these points.

The current systematic review was conducted to investigate the effects of vitamin D supplementation on vitamin D levels, bone health, and physical performance indices in adults with spinal cord injury (SCI).

The PubMed, Scopus, Web of Science, and Embase databases were searched for studies published up to June 2020, with no language limits. To determine the risk of bias, the Academy of Nutrition and Dietetics Quality criteria checklist was used.

Eight studies that met all of the inclusion criteria were identified. All of the eligible studies had a high level of heterogeneity regarding outcome measures, study design, and the dose of vitamin D. The majority of the trials showed beneficial effects of vitamin D supplementation on serum vitamin D levels and other outcome measures in patients with SCI. Three randomized controlled trials revealed a low risk of bias, whilst other studies were rated as the  either neutral or negative risk of bias.

This review suggests that vitamin D supplementation could improve vitamin D levels, bone health, and physical performance indices in individuals with SCI. However, due to the high level of heterogeneity, the results should be interpreted with caution. Further studies on this population should be performed to have sufficient power and a robust design to give definitive conclusions.

The purpose of this study was to investigate the effect of attachment-oriented couple therapy on intimacy, sexual satisfaction, empathy and marital self-disclosure of women with marital conflict in Isfahan city. The method of the current research was quasi-experimental with a pre-test, post-test with a control group and a 2-month follow-up phase. The statistical population was all married women with marital conflicts who referred to counseling centers and psychological services in Isfahan city in 2022. In the first stage, using the purposeful sampling method, 30 people had marital conflicts, they were selected and then they were replaced by a simple random method in an experimental group (15 people) and a control group (15 people) and they were asked the marital conflicts questionnaire of Sanai Zaker et al. (2008), Thompson and Walker's Marital Intimacy Scale (1983), Meston and Trapnell's Sexual Satisfaction Questionnaire for Women (2005), Jolliffe and Farrington's Basic Empathy Scale (2006) and Waring et al.'s Marital Self-Disclosure Questionnaire (1998) responded. Data were also analyzed through mixed analysis of variance and Bonferroni post hoc test using SPSS-26 software. The results showed that the mentioned treatment had a significant effect on the intimacy, sexual satisfaction, empathy and marital self-disclosure of women with marital conflict in the post-test and follow-up phase compared to the control group (P<0.05). Attachment-based couple therapy can be used as a suitable treatment method to improve intimacy, sexual satisfaction, empathy and marital self-disclosure of women with marital conflict in counseling centers and psychological services.

The present study aims to answer this question, what are the themes of dealing with corruption in Iran's administrative system, and in this regard, seven documents related to the issue of corruption in Iran were identified, and the researcher, by carefully examining and studying these documents, first counted the related concepts and the integration of concepts that had a common semantic load, paid attention to the explanation of the main themes and then the organizing and inclusive themes. The current research is fundamental in terms of its purpose, in terms of the method of qualitative research, which can be included in interpretive research, and in terms of strategy, thematic analysis method was used, and the method of data collection was through the study and review of documents. Based on the findings of the research, the number of 52 concepts, 18 main themes, 13 organizing themes and 7 comprehensive themes regarding the fight against corruption were explained and then the network of themes that shows the relationship between the fundamental concept on which the research is based and the inclusive and organizing themes, was designed.

The coronavirus disease 2019 (COVID-19) pandemic has prompted researchers to look for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenicity in depth. Immune system dysregulation was one of the major mechanisms in its pathogenesis. The evidence regarding the levels of interferons (IFNs) and pro- and anti-inflammatory cytokines in COVID-19 patients is not well-established.

This study evaluated the expression level of type-I, II, III IFNs, along with interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), and FOXP3 genes in patients with severe COVID-19 to provide additional insights regarding the regulation of these cytokines during COVID-19 infection.

Peripheral blood mononuclear cells were isolated from two groups, including severe COVID-19 patients and healthy controls. Ribonucleic acid was extracted to evaluate the expression level of IFN-a, IFN-b, IFN-g, IFN-la, IL-1, IL-6, IL-10, and FOXP3 genes using real-time polymerase chain reaction. The correlations between the expression levels of these genes were also assessed.

A total of 40 samples were divided into two groups, with each group consisting of 20 samples. When comparing the severe COVID-19 group to the controls, the expression levels of IFN-g, tumor necrosis factor-alpha (TNF-), IL-6, and IL-10 genes were significantly higher in the severe COVID-19 group. The two groups had no significant differences in IFN-a, IFN-b, IFN-la, IL-1, and FOXP3 expression. The correlation analysis revealed a negative correlation between type I and type III IFNs (i.e., IFN-a and IFN-la) and proinflammatory cytokines (i.e., IL-1 and IL-10).

This study suggests the possible upregulation of IFN-g, IL-6, IL-10, and TNF-during SARS-CoV-2 pathogenicity. The preliminary findings of this study and those reported previously show that the levels of IFNs and pro- and anti-inflammatory cytokines are not uniformly expressed among all COVID-19 patients and might differ as the disease progresses to the severe stage.

Natural killer (NK) cells play a role in the pathogenesis of rheumatoid arthritis (RA). Upregulated levels of programmed cell death protein 1 (PD-1) is a sign of exhausted NK cells that could be regulated by microRNAs (miRNAs). In this investigation, we determined PD‑1 expression on NK cells (as a representation of NK cell exhaustion) in RA patients and evaluated if miRNAs are involved in the modulation of PD-1 expression in NK cells. Peripheral blood specimens were obtained from 40 RA patients and 20 healthy subjects. NK cells were isolated by negative selection from a pool of peripheral blood mononuclear cells. The frequency of PD-1–expressing NK cells and the expression of PD-1 on NK cells were analyzed by flow cytometry. Real-time PCR was used to measure the expression levels of PD-1 mRNA and miRNAs in the NK cells. The percentage of the PD-1–expressing NK cells and Mean fluorescence intensity (MFI) of PD-1 expression on the NK cells were significantly higher in the RA cases compared to the controls. The mRNA expression of PD-1 was significantly upregulated in NK cells from RA patients compared to healthy subjects. The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group. In RA, miRNAs probably regulate the NK cell exhaustion process through driving PD-1 expression.

The effort to reduce harm by adopting risk reduction strategies to establish a safe environment is known as school resilience to disasters. Resilient schools have a good capacity in disasters and their educational mission. Following natural disasters, schools play a critical role in the recovery of society. The study aims to assess the resilience of schools to disasters in Kermanshah, Iran.

This research is a cross-sectional descriptive-analytical study. A proportionate stratified random sampling strategy was used to select 231 participants from schools in Kermanshah. Total resilience showed the weakest (r = 0.499) and strongest (r = 0.910) correlations with location and function. Data were collected using standard school resilience in disasters questionnaire and analyzed using SPSS version 22. Statistical tests such as Pearson correlation, independent t-test, and one-way ANOVA were conducted at a significant level of 0.05.

The results showed the X ± SD of the total resilience score (143.61±32.50). The highest and lowest mean scores among the resilience dimensions were assigned to function (43.81± 13.11) and safety (6.59± 3.40) dimensions, respectively. In addition, there was a significant positive correlation between total resilience and its dimensions (P <0.001). Total resilience showed the weakest (r = 0.499) and strongest (r = 0.910) correlations with location and function dimensions.

The level of school resilience was determined to be moderate. It can assist the schools’ management board in analyzing the schools’ level of resilience and setting disaster risk reduction priorities. Awareness of the resilience state can aid policymakers and professionals in developing an effective resilience program.

Cheese is a product consisting of fat and milk protein, along with calcium and phosphorus that are combined with milk protein in various ways. Due to the importance of cheese consumption among the people of Iran and considering that this product is one of the most important dairy products and according to available statistics, about 20% of the milk produced in the dairy industry is converted into cheese, of which the share of production Traditional cheese is about 80%. The purpose of this study was to evaluate the level of contamination of traditional cheeses offered in different areas of Karaj. The present descriptive cross-sectional study was conducted in the summer of 1398 by sampling different parts of the north, west, east, south and center of Karaj . Four types of bulk cheeses of Tabriz Ligvan, lactic, white and gypsum in five geographical areas with three replications were examined for the presence of Staphylococcus aureus. The results shows the contamination of traditional cheeses and its different areas, although the rate of contamination in the west was higher than other areas. Among the regions, the eastern region with the lowest level of pollution among other regions and the presence of contamination only in gypsum cheese, was identified as the least dangerous region. In contrast to the existence of high pollution in all four types of cheese studied in the west. based on the results, this part of Karaj was introduced as the most dangerous area in the consumption of traditional cheeses.

The family has an unparalleled position in the system of the Islamic Republic of Iran and in other social systems. Accordingly, in the economic, social and cultural development programs of the country, the family and its excellence and consolidation have always been emphasized. However, scientific observations and researches show that it is important that the path that this social institution has taken in recent years in Iran has not been expected by development planners. Accordingly, the present study began with the assumption that "there is a gap between the real components of family consolidation and the components of social development planners."The present study was conducted using documentary and field methods and questionnaire technique for 390 young people on the verge of marriage. The results of this study show that unfortunately about half of the girls and boys on the verge of marriage are reluctant to marry and the social and economic infrastructure to meet the basic needs of a life for them in accordance with the patterns and structures of today's Iranian society is not provided. This, in combination with other macro and micro components of society, has caused serious challenges for the survival and excellence of Iranian families. Finally, by examining the hypotheses of the present study, the relationship between socio-economic status, religious beliefs and social support with strengthening the foundation of the family was confirmed.

With the expansion of urbanization and the development of industry, environmental pollution, including sources of drinking water to heavy metals, has become a global problem. Therefore, the present study was conducted to measure the concentration of lead and cadmium in the water of Gorgan distribution network.

This is a descriptive cross-sectional study in which the concentrations of heavy metals lead and cadmium were measured in 25 different stations of the Gorgan drinking water distribution network from April to September 2018 by atomic absorption device. Statistical analysis was used from SPSS ver 22 software. Also, zoning maps based on the concentration of these two metals were prepared by Geographic Information System (GIS) software.

The results of measuring the lead and cadmium concentration showed that all measured values are less than national and international standards. In general, the average concentrations of lead and cadmium were 4.38 and 0.1 μg/L, respectively. The results of Kruskal-Wallis test showed that there was a significant difference (p <0.01) between the concentrations obtained from lead metal in different months. Additionally, the distribution map of this lead and cadmium exhibited that in the central areas and some border areas, the concentration of these two metals is higher.

According to the obtained results, it can be seen that the concentration of heavy metals lead and cadmium in the water of Gorgan distribution network is within the permitted standards.

The aim of this study was to investigate the role of organizational pessimism as a mediating variable in the relationship between perceived organizational support and employees' anti-productivity behavior. The research is descriptive-survey in terms of practical purpose and in terms of nature and method of implementation. The statistical population of this study consisted of the staff of the General Office of Standards of Khorasan Razavi, due to the limited statistical population, the census was used. In this study, the Nayr Questionnaire (2013) was used for the organizational support variable, the Kalagan Organizational Pessimism Questionnaire (2009) was used for the organizational pessimism variable, and the Bennett and Robinson (2002) questionnaire was used for the anti-productivity behavior variable. The validity of the questionnaire was confirmed through face and content validity and the reliability of the questionnaire was confirmed using Cronbach's alpha coefficient. Data were analyzed by correlation test and structural equations using SPSS22 and PLS 3 software. Structural equation modeling findings showed that organizational pessimism mediates the relationship between perceived organizational support and anti-productivity behavior.

Ethical behavior is of particular importance to public agents and it can be seen both as a framework for improving political and administrative actions and a criterion for assessing the amount of commitment of public agents so as to achieve the public benefit. The purpose of this study is to identify the ethical behavior of public agents based on Sa'di's Golestan.

The present study is exploratory in nature, conducted through inductive approach, and located on the framework of the interpretive paradigm. The second chapter of Sa'di's Golestan serves the data source of the study and theme analysis was used to analyze the data. Validity of the results was assessed and confirmed using census method done by an assessor and their reliability was assessed and confirmed Using Holsty method.

The findings of the present study indicated that the ethical behavior of public agents, based on the second chapter of Sa'di's Golestan, has 48 basic themes, 16 organizing themes, and four comprehensive themes. Comprehensive themes include slavery ethics, individual ethics, social ethics, and political ethics.

The explained model can be used as a guide to improve ethical behavior of public agents so as to pay more attention to public benefits, motivate staffs, increase the legitimacy of public agents, and develop political and administrative actions.

Due to occurrence of fires in process industries, it is vital to implement crisis management systems in these industries and keep the readiness of these systems high. The purpose of this study is to evaluate the readiness of emergency response teams to deal with a possible fire in a process industry.

This descriptive-analytical study was performed in 2019 in a gas refinery with a statistical population of 200 people. A questionnaire with Likert scale was designed through library and field studies for all teams participating in the firefighting process. Content Validity Ratio (CVR) and Content Validity Index (CVI) were used to measure validity and Cronbach's alpha coefficient was used to measure the reliability of the questionnaires. The collected data were entered into SPSS software version 24 and statistical analysis was performed at 95% significance level using One Way ANOWA test.

The results showed that the readiness of this refinery to deal with a possible fire was 68.3%, which among the 11 teams participating in this process, the security team with 53.48% had the lowest and the logistics team with 77.5% had the highest preparedness (P-value = 0.028). The highest CVR was for the safety team questionnaire (0.77) and the highest Cronbach's alpha coefficient was for the liaison team (0.92).

The results of this study showed that the readiness of this gas refinery in the firefighting process is satisfactory, although some teams, including the security team, are less prepared than other teams. Therefore, it is better to take intervention measures as soon as possible, including providing the necessary equipment and providing various trainings and maneuvers in order to increase the readiness of the teams.

Methotrexate (MTX) is one of the most effective therapeutics to treat different types of solid tumors; however, it suffers low permeability limiting its bioavailability and cellular uptake. To tackle this, we aim to design and fabricate different types of cell-penetrating peptides (CPPs) to improve the intracellular uptake of MTX without causing any immunogenic response. CPPs were synthesized by the solid-phase peptide synthesis method. Peptide-MTX conjugates were prepared via covalent binding of peptide and drug molecule. CPPs and peptide-E8 nanoparticles were characterized using zeta-sizer and scanning electron microscopy. Cytotoxicity of CPPs and peptide-MTX conjugates was evaluated by MTT assay. An enzyme-linked immunosorbent assay was employed to assess the IL-6 and TNF-α cytokine release profile. Amongst all sequences, W4R4-MTX possessed the highest loading efficiency (97%) and drug to peptide percentage (24.02%). The lowest loading efficiency (36%) and drug to peptide percentage (8.76%) were seen for NGRWK-MTX conjugates. The NGRWR peptide and NGRWR-E8 nanoparticles had acceptable size (~100 nm) with spherical and rod-like structures, respectively. The selected CPPs and peptide-MTX conjugates did not show any cytotoxicity or immunogenicity. The fabricated peptides are represented as promising carriers to improve the intracellular delivery of MTX to cancer cells with low immunogenic and cytotoxic effects on normal cells.