hasan jalili

Effectiveness of innovative human capital performance of knowledge-based herbal pharmaceutical companies and adopting forward-looking strategies to achieve it is important. aim is to provide an effective innovative human capital.

Research approach is mixed. targeted sampling was done with 15 experts in the health sector and managers of knowledge-based herbal medicine units in the country. For model tesingt, 169 questionnaires were collected from the researchers of knowledge-based units of herbal medicine. data analysis for model discovery is based on grounded theory and structural equations for model testing.

The model with six main dimensions (market-oriented dominance), (innovative human capital), (herbal therapy cultural environment), (weakness of policy making, standardization and innovation creating valuing), (futuristic strategic management of health), (future market knowledge) and 17 components,126indicators were confirmed. the fit indices of the model were NFI=0.926, GOF=0.569 and SRMR=0.071, which indicates fit of the research model.

Managers by adopting strategies of increasing and sharing the flow of information and knowledge between specialist employees, project supervisors and other stakeholders in the supply chain - having a learning and forward-looking management style in selection, employment, training and how to behave with specialist employees in projects - adopting smart management style in business processes as market measurement, customer orientation, competition orientation, improving the quality of drug production and creating an atmosphere of win-win interaction with other knowledge-based enterprises and herbal pharmaceutical industries, can witness the effectiveness of human capital by gaining knowledge of the future market.

knowledge-based firms institute for innovative outputs and lean to human capital for innovation. From other perspective, performance effectiveness of these assets and their innovational consequences are very important. This research aim to deliver a model for effectiveness in performance innovative human capital of knowledge-based firms.

This study is fundamental and performed in qualitative nature with ground theory . Research community involve health and drug experts. 15 of whom were selected using purposive sampling method and performed semi-structured interviews until recieving theoretical saturatin. interviews after recording immidiatly used for coding. data analysis was performed using three stages of open, axial and selective coding in the style of a systematic method of grounded theory.

The analyzing of interviews lead to a model with six main dimensions which are market-oriented learning challenges, human capital learning behaviors ,general rulling content of health, intervening conditions, new opportunist management strategy for sanction conditions of knowledge-based firms, effectiveness performance and 29 subdimensions.

Knowledge-based firms to overcome sanction conditions use new opportunist management strategy to educate human capital and lead to upgrade internal and external organizational performance of knowledge-based firms.

Since the beginning of the 21st century, coronaviruses that originated from animals to human have been the cause of several deadly pneumonia epidemics including SARS, MERS disease, and now COVID-19 which has become a worldwide pandemic. The emergence of these acute respiratory syndromes emphasizes the cross-species transmission of coronaviruses and their prevalence in humans. Coronaviruses contain a surface- spike protein (S) that initiates infection by recognizing its receptor and attaching to the membrane, which is a key step in the host specificity and intergenerational transmission. To date, no specific treatment or vaccine against any of the seven human coronaviruses has been approved. This underscores the importance of exploring the mechanisms governing the virus entry and intergenerational transmission. This review article discuss the mechanism of infection used by coronaviruses by focusing on the features of the S protein and its receptor binding characteristics in different species. In addition, protease processes involved in the onset of infection was considered to provide a complete picture of their role in the coronavirus replication cycle. Finally, treatments based on the interaction of S-protein and ACE2 receptor were described.

Chlorella is a unicellular green algae that produces the highest amount of chlorophyll among of organisms. Some of important metabolites in chlorella are astaxanthin, chlorophyll a and chlorophyll b. So far some of chemicals used as inducer for increasing algal metabolites which one of them is ethanol. Effect of ethanol on cell growth and lipid content of microalgae and plants has been studied. In this research, the effect of ethanol on astaxanthin, chlorophyll a and b production in chlorella sorociniana was investigated for the first time. The result of spectrophotometry showed that addition of 10 μl of ethanol (in 100 ml) will enhance the astaxanthin for 1.4 times. However, chlorophyll production changed a little in the presence of 100 μl of ethanol. According to regulatory role of phytohormones in microalgae, it can be conclude that ethanol acts as a signal and regulates some of metabolites production.

Biosurfactants are increasingly used by food industries due to their low toxicities and unique structures. In this study, biosurfactants were produced and characterized for the first time using acidic bacteria isolated from acidic hot springs in Bushehr Province, Iran. Screening and identification of the most efficient species for biosurfactant production were carried out on 12 bacterial species using several experiments such as hemolysis, surface tension, emulsification index and diameter of clear zone. In addition to biosurfactant production, kinetics, stability and structural and thermal analysis were carried out for the bacterial strains using thin layer chromatography, Fourier Transform Infrared, nuclear magnetic resonance and differential scanning calorimetry. The biosurfactant from the selected bacteria (0.1 g l-1) was thermally stable at 120°C for 30 min. Stability at temperatures up to 140°C was confirmed using differential scanning calorimetry. The most significant novelty included the fact that the surface property was preserved until an osmolarity of 4% w v-1. Decreased surface tension and the emulsification potential were only reported at concentrations higher the highlighted concentration. Biological assay showed that Staphylococcus aureus was susceptible to produced biosurfactants, while no susceptibility was seen in Escherichia coli. Degeneration of SW480 cell line exposed to 0.601 µg µl-1 of the biosurfactant was detected after 24 h. The structural analysis showed that the biosurfactant was similar to surfactin as a food bioemulsifier. The authors declare that they have no conflict of interest.

Demand side managemnt resources always were used as important options in planning and operation. Studies about them were done in some capacity markets and some others like PJM was used from these resources in their capacity markets. But, it is so important that first a study about them should be done and then a structure for using them in the capacity market shpuld be proposed.
Participation of demand side management resources in capacity market just must be done by retailers, because of economic and management reasons. So, we must develope a model from retailer's product and the ways of their business in capacity market. This modeling will have the benefits for retailers and consumers. Therefore, in this paper a model for retailer's behavior have been proposed. Numerical studies have been shown the efficiency of the model.

Participation of load in operation of power system is essential for operators and the economy is the first option for this purpose. This participation nominated as demand response programs (DRPs). DRPs result in reducing reliability cost and electricity price, congestion relief and reduction in environmental impacts. What is important is the proposing a comprehensive DRPs model for accurate planning. Different model of DRPs is proposed that is nominated as static and dynamic models in this paper. Dynamic models used from demand elasticity to price that is different for each customer. This issue brings inaccuracy in model and poor planning.
In this paper a comprehensive model of DRPs based on price elasticity to total demand is proposed that is same for all customers. So, inaccuracy in model and poor data base challenge will be removed. Numerical results show the effectiveness of the proposed model.

Chlorella vulgaris is a multi-cellular edible algal species with abundant proteins. Extraction of high value protein fractions for pharmaceutical and nutritional applications can significantly increase the commercial value of microalga biomasses. There is no known report on the anticancer peptides derived from the Chlorella vulgaris abundant protein.
This study examined the antimicrobial and anticancer effects of peptides from a hydrolyzed Chlorella vulgaris protein with 62 kDa molecular weight. Protein hydrolysis was done by pepsin as a gastrointestinal protease, and was monitored through protein content measurement, sodium dodecyl sulfate polyacrylamide gel electrophoresis, and high performance liquid chromatography measurements. Inhibitory effect of the produced peptides on Escherichia coli cells and breast cancer cell lines was assayed.
Results and Hydrolyzed peptides induced a decrease of about 34.1% in the growth of Escherichia coli, and the peptides of 3 to 5 kDa molecular weight had strong impact on the viability of breast cancer cells with IC50 value of 50 μg μl-1. The peptide fractions demonstrating antimicrobial and anti-cancer activities have the potential for use as functional food ingredients for health benefits. These results demonstrate that inexpensive algae proteins could be a new alternative to produce anticancer peptides.

Production of recombinant proteins such as β-NGF using prokaryotic hosts is the topic of many recent researches. However, bacterial cell culture media are cheaper than eukaryotic cell culture media, but in industrial production scale they are not cost effective at all for biotech companies. Therefore, survey to find inexpensive cell culture medium that bacterial cells not only can grow in it but also produce recombinant proteins is very important. In this study, for the first time date syrup and yeast extract mixture was used as an inexpensive medium. In RSM (response surface methodology) studies different concentrations of date syrup and yeast extract were used as carbon and nitrogen sources respectively. The results indicate that the 20 g/lit of carbon and 5 g/lit of nitrogen are optimum for bacterial growth. Also the data show that recombinant bacteria not only can grow but also can produce recombinant proteins such as β-NGF using this synthetic medium.

Effects of catechin for preventing black spots forming in whiteleg shrimp (Litopenaeus vannamei) were evaluated. For processing whole shrimp، catechin was used at a concentration of 0. 2 and 0. 3 % for 15 minutes. Sodium metabisulfite was used at a concentration of 3 % for 10 minutes as control samples. Without antioxidant shrimp were used as control samples too. Treatments quality was evaluated by Sensory analysis and chemical experiments during 6 months being kept in frozen storage. pH، total volatile basic nitrogen and trimethylamine factors in 0. 3 % catechin treatments showed significant differences During the storage period (P0. 05). TMA، FFA and TVB-N factors in Sodium metabisulfite treatments showed significant differences compared to other treatments (P0. 05). PV، TBARS، FFA، pH and TVB-N factors in 0. 2 and 0. 3 % catechin treatments showed no significant difference during the storage period compared to Sodium metabisulfite treatments (P>0. 05). But they showed significant differences compared to without antioxidant treatments.

Capacity market is one of the most successful mechanisms to ensure power system adequacy where generation units sell their capacity in a competitive manner. High investment costs, long construction periods and lack of competition between generation units in some sections of the grid are factors which may justify resources based on demand side management deployment in capacity market. Hence this paper aims at reducing reliability costs and generations markets power using mentioned resources deployment in capacity market. The reliability cost is calculated as some of costs paid to the generators proportionate to their share. Furthermore, market power of players is evaluated using MRCI index. The proposed method is tested in IEEE 57 bus network and results are reported.and results are reported.

The influence of whey permeate powder and yeast extract concentration as nitrogen source in skim milk based media on growth, β-galactosidase activity and organic acid profile of Bifidobacterium animalis subsp. lactis Bb 12 in batch fermentation was investigated. B. animalis had diauxic growth in these mediums. β- galactosidase activity increased in growth phase and primary stage of stationary phase and then decreased. Increasing in yeast extract concentration increased specific sugar consumption rate and this rising change, was accompanied with reduction in acetic and formic acid formation. These changes were followed by a decrease in molar ratio of acetic acid to lactic acid consequently. When insufficient initial usable nitrogen and adequate carbon source existed in medium, a disorder between growth and organic acid production was observed. In this case specific enzyme synthesis rate is very high in the early hours of fermentation. Succinic acid was produced continuously at growth and stationary phase in all fermentation media. Citric acid could be consumed at stationary phase by this microorganism and its consumption, was extremely correlated with production of succinic acid at this stage (R2= 0.9). Insufficient nitrogen amounts in medium cased shift from anabolism to catabolism for this microorganism. This phenomenon can affect on organoleptic properties of fermented food.