hosein abednatanzi

The aim of this study was to investigate the response of beta-cateninand bax gene expression in liver tissue of mice with melanoma to a period of aerobic exercise with nettle extract.

In this study, 20 adult male rats were randomly divided into 4 groups including: control, exercise, extract and exercise + extract. The training program consisted of 30 minutes of running on a treadmill without a slope at a speed of 16 meters per minute for the first week, and one meter per minute was added every week until it reached 22 meters per minute in the eighth week. One week after melanoma induction, the experimental group consumed 30 mg / kg / day of nettle ethanolic extract orally for 8 weeks. RT PCR was used to measure the expression of beta-cateninand baxgenes.

Data analysis showed that Beta-catenin gene expression was increased in the experimental groups compared to the control group; But did not reach a significant level (p = 0.103). The results also showed that BAX gene expression was significantly reduced in the experimental groups compared to the control group (p = 0.026).
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The results show that consumption of nettle extract along with aerobic exercise by reducing BAX levels and increasing beta-catenin in activating the WNT / beta-catenin signal pathway and apoptosis has an immune stimulus to prevent tumor growth and cancer progression.

 Type 2 diabetes is a complex metabolic disorder characterized by insulin resistance and glucose dysregulation. It is a major concern of the World Health Organization, affecting millions of people worldwide. The purpose of this study was to investigate the effect of  8 weeks of high-intensity interval training on the expression of activating transcription factor-6 (ATF-6) and C/EBP homologue (CHOP) proteins in liver tissue in rats with type 2 diabetes. 

  The current study was experimental with a post-test design with a control group. A number of 24 Wistar male rats, aged 6 weeks and weighing approximately 200-250 grams, were obtained from the Pasteur Institute of Iran. Rats were randomly divided into 3 groups of 8 high intensity interval training (HIIT) diabetic, diabetic control and healthy control. The training groups performed 5 HIIT training sessions on the treadmill during 8 weeks and each week (the training protocol was 8 weeks of interval training, 5 sessions per week with intense 2-minute intervals with 2-8 repetitions and 80-90 The percentage of maximum running speed and 1-minute rest intervals were performed with 50-56% of maximum running speed. After 48 hours from the last training session and after fasting days, all rats were anesthetized and liver tissue was harvested. The data were analyzed by one-way analysis of variance (ANOVA).

 The results showed that ATF-6 protein levels in type 2 diabetic male rats did not change significantly after 8 weeks of high-intensity interval training (P = 0.73). But CHOP protein levels showed a significant increase after 8 weeks (P = 0.001). CHOP protein levels in the diabetic training group showed a non-significant decrease compared to the diabetic control group (P < 0.05), but in the diabetic training group compared to the healthy control group, it showed a significant increase (P = 0.001).  

 As a result, 8 weeks of high-intensity interval training can have beneficial effects on reducing endoplasmic reticulum stress in liver tissue caused by type 2 diabetes in diabetic rats. Furthermore, further research is needed to confirm these findings and explore the potential mechanisms involved.

Atherosclerosis is a mechanism of cardiovascular disease which characterized by endothelial dysfunction related with flow-mediated dilation (FMD). The purpose of this study was investigation of 12 weeks of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on plasma levels of vaspin, nitrite/nitrate (NOx) and relation with FMD in T2D. 48 patients with T2D were randomly assigned to three groups: HIIT (n= 16), MICT (n= 16) and control (n=16). The HIIT group intervention was 12 intervals at 85-90% maximal heart rate (HRmax) and 2 min at 55-60% HRmax. The MICT group intervention was performed on ergometer cycle for 42 min of exercise at 70% HRmax for 3 sessions per week during 12. The blood sample was collected 48-h before and 48-h after last sessions of exercise training. The vaspin was measured by ELISA, and NOx messured by Griess assay. FMD was assessed by ultrasound in baseline and follow-up 12- weeks of intervention. Data were analyzed using mixed- liner ANOVA with SPPS version 18. The results showed that plasma levels of vaspin and NOx and FMD percent after 12-weeks intervention (HIIT and MICT) were significantly increased compared to control group. There is no significantly different between HIIT and MICT in plasma levels of vaspin. While, there are significantly increased in plasma levels of NOx and FMD percent between HIIT and MICT (P< 0.05). Additionally, result indicated that there is a positive correlation with vaspin and NOx with FMD in HIIT group (P= 0.001) and vaspin (p=0.037) and NOx (P=0.026) in MICT group (P= 0.037). It seems that intensity via increase of vaspin and NOx plasma levels led to improves of FMD in patients with type 2 diabetes.

Cardiotrophin-1 (CT-1) is an interleukin-6-related cytokine with known hypertrophic and protective actions upon cardiac myocytes. The present study aimed to investigate the impact of 1- week aerobic exercise on serum levels of cardiotrophin-1 in female patients with hypertension.

in this study, 35 old women aged 50 to 70 were randomly divided into two groups (15 controls and 15 controls). The exercise program included aerobic exercises conducted increasingly 3 times a week for 12 weeks. Before the exercise, and 24 hours after the last session, blood samples and the body composition were taken. Data were collected and analyzed using one-way ANCOVA and Tukey post hoc test at a significant level of P≤0/05.

According to the results, twelve weeks of exercise did not significantly affect CT-1 level.

Overall, it seems that 12-week aerobic exercise has been beneficial in patients with hypertension and has been improving myocardial function; however, further studies are needed.

The purpose of this research was to explain the protective effect of quercetin on cardiac fatigue caused by exercise in skyrunning runners.

26 professional sky running athletes voluntarily and purposefully participated in this race. Random people were placed in 2 groups: quercetin (13 people) and placebo (13 people). The race was held in the central Alborz mountains, the total distance traveled was 21 km and 200 meters, the altitude of the starting point was 1650 meters above sea level, the maximum altitude was 3150 meters above sea level. Before and immediately and 1 hour after the end of the race, blood was taken from the subjects. In order to check the changes of the studied variables, the independent T-test was used at the significance level of alpha 0.05.

The amount of cardiac troponin T decreased significantly immediately and 1 hour after the end of the race in the quercetin group compared to the placebo group (P < 0.05). No significant difference was observed between the two groups of quercetin and placebo in the pre-test, immediately after the test and 1 hour after the test (P>0.05).

It seems that the increase of free fatty acids after the competition and long-term sports play an important role in reducing cardiac inotropic during the same period. Skyrunning competitions cause an increase in heart damage indices in professional athletes, despite this, quercetin supplementation reduces the increase in cardiac troponin T and can have a protective effect on the athlete's heart

The aim of this study was to evaluate the effect of nettle extract consumption and aerobic exercise on VEGF and caspase 3 gene expression in mice with melanoma.

In this study, 20 adult male rats with age of 8 week were randomly divided into 4 groups including: control, exercise, extract and exercise + extract. The training program consisted of 30 minutes of running on a treadmill without a slope at a speed of 16 m/min for the first week, and one meter per minute was added every week until it reached 22 meters per minute in the eighth week. One week after melanoma induction, the experimental group consumed 30 mg /kg /day of nettle ethanol extract orally for 8 weeks. RT PCR in blood was used to measure the expression of VEGF and caspase 3 genes.

Data analysis showed that VEGF gene expression was decreased in experimental groups compared to the control group; But did not reach a significant level (p = 0.154). The results also showed that caspase 3 gene expression was significantly increased in the experimental groups compared to the control group (p = 0.000). Post hoc test also showed that caspase 3 gene expression was significantly different between the combination group and other groups.

The results showed that consumption of nettle extract may have anti-cancer effects through various mechanisms such as antioxidant activity, induction of apoptosis inhibition of cell growth and cell migration.

The aim of this study was to evaluate the effect of nettle extract consumption and aerobic exercise on COX-1and COX-2gene expression in mice with melanoma.

In this study, 20 adult male rats were randomly divided into 4 groups: 1. control, 2. physical exercise, 3. nettle extract, 4. physical exercise + nettle extract. A week after inducing melanoma, the experimental group consumed 30 mg / kg / day of nettle ethanol extract orally for 8 weeks. The training program consisted of 30 minutes of running on a treadmill without a slope at a speed of 16 meters per minute for the first week, and one meter per minute was added every week until it reached 22 meters per minute in the eighth week. RT PCR was used to measure the expression of COX-1and COX-2 genes.

The results of the present study showed that consumption of nettle extract and aerobic exercise caused significant changes in COX-2 levels in experimental groups compared with the control group. COX-2 levels in the extract and combination groups were significantly reduced compared to the control group. Also, the results showed that COX-1 levels were significantly different between the experimental and control groups.

The results of the present study showed that the chemical compounds in nettle extract such as flavonoids, terpenes, fatty acids and phenolics may be responsible for apoptotic and anti-cancer effects. Also, endurance training caused a significant decrease in COX2 levels compared with the control group.

Effective use of medications as methadone with exercise training can facilitate the development of healthy. The aim of this study was to compare the effect of different training with methadone on fibrinogen and lipid profile of addicted men.

90 addicted men are treated in prison (36.8 ± 4.3yrs) were randomly divided into six groups (n=15): control, Narcotics Anonymous(NA), aerobic training + methadone, aerobic training + methadone reduction, resistance training + methadone, Resistance training + methadone reduction. Experimental groups performed training for 12 weeks, three sessions in week. Aerobic training consisted of 4 to 8 sets, 3-min at 80–90 % maximum heart rate (HRmax) on a cycle ergometer. Resistance training performed with 8 to 12 repetitions, 3 sets and 70-85% one repetition maximum(1RM). Data were analyzed by SPSS software and Multiple analysis of variance (MANOVA) and Tukey post hoc test at the significant level (P≤0.05).

The high-density lipoproteins (HDL) level of blood in the training groups was significantly increased (P≤00001) compared to the control group. Also, low-density lipoproteins (LDL, P≤0.005), Triglycerides (TG, P≤0/008), Total Cholesterol (P≤0/014 and fibrinogen (P≤00001) levels were significantly reduced in the training groups compared to the control group. Also, the aerobic training groups had a greater effect of all the measured variables than the resistance training.

regular exercise, especially aerobic and resistance exercises with a reduction in methadone has a favorable effect on inflammatory factors and ultimately the health of addicted people

Contrary to pathological conditions, structural changes and adaptations in response to regular exercise are a physiological phenomenon. Aerobic activity follows an extrovert hypertrophy pattern by applying a kind of volumetric load on the heart muscle. While the pattern of changes due to resistance or strength exercises occurs due to pressure stress in the form of introverted hypertrophy. However, athletes in many sports between the two ends of the continuum and endurance and resistance exercises, usually inevitably use combined exercises that have both the characteristics of pressure and volume push-ups (4, 5).However, there is much disagreement about the effect of short-term exercise on young non-athletes and its effect on structural and functional changes in the heart, and although not enough information is currently available, research findings show that in Response to regular exercise The cardiovascular system undergoes significant positive changes. In addition to the above, it is important to study the effect of various sports exercises on the structure of the heart (8).However, despite much research on ECG and exercise, resistance exercise and ECG and echocardiography have been studied simultaneously and less in endurance-resistance training, and most research on aerobic exercise, disease, and postoperative recovery has been studied. Cardiac surgery has been performed. Therefore, in this study, structural changes in the heart in response to short-term and long-term endurance-resistance training in young non-athlete men are studied and the question is answered whether short-term and long-term combined (resistance-endurance) training Does it affect some structural variables in the heart of young non-athlete men?

The present study is a quasi-experimental study that was conducted in the field and laboratory with a group of 12 people and 3 experimental stages. For the present study, 12 non-athlete young men aged 20 to 30 years in Saveh were randomly selected as the sample. Then, before starting the training program, the consent of all subjects was obtained to participate in the research. Then, the research variables in the pre-test were measured using an electrocardiograph and the subjects performed a short-term combined training program (resistance-endurance) for 4 weeks. After 4 weeks, they underwent ECO again and exercises for another 4 weeks. Did their own thing and finally ECO came out of them again.To perform the research protocol, first a maximum repetition of the subjects was calculated, then they warmed up for 10 minutes and performed strength exercises including four movements of foot press, chest press, armpit and leg stretching in such a way that all movements in the arms and legs in The first week was performed with 50% of a maximum repetition in 2 turns with 10 repetitions and with a rest frequency of 1 to 2 minutes between each turn. The intensity of training increased increasingly and reached 80% 1RM in 3 turns with 6 repetitions in the eighth week. After each session of resistance training, the subjects performed endurance training including running with a working intensity of 65% of maximum heart rate on the treadmill for 16 minutes in the first week to 80% of maximum heart rate for 30 minutes in the eighth week (11) .Finally, to describe the data from the central indicators, dispersion and drawing of tables, and from Shapir-Wilk tests and analysis of variance with repeated measures by software (SPSS) version 23 at the significant level of p≥0.05 It was used for inferential analysis of data.

The results of statistical analysis of Khadr research data showed that short and long-term combined (resistance-endurance) training on left ventricular end-diastolic end diameter (p = 0.398), left ventricular systolic end diameter (p = 0.480), aortic diameter At the root level of AO (p = 0.756), transverse diameter of right ventricle (p = 0.997) and thickness of interventricular septum (p = 0.759) of young non-athlete men had no significant effect (Table 1).

The results of the present study show that short and long-term combined (resistance-endurance) training has no effect on the left ventricular diastolic end diameter of young non-athlete men, but the effect size of 8 weeks of training is less than 4 weeks of training. Exercise restores the structure of the left ventricle of the heart, which is mediated by many aspects of exercise as well as individual characteristics. Different sports are a combination of compression and volume overloads and there is absolutely no volume and pressure overload in any of the sports activities. There are many factors that can affect left ventricular preload and postload, all of which can affect the size of the left ventricular diastolic end as much as exercise or even more.Increasing the thickness of the posterior walls of the left ventricle indicates an overload of pressure on the heart walls. Repetition of strong contractions during exercise stimulates the necessary ventricular wall hypertrophy and thus increases the thickness of the left ventricular wall. When the heart is exposed to acute exercise conditions, there are changes in heart rate and strength, and when it is exposed to these pressures over a long period of time, there are changes in the size of the heart cavities and the thickness of the ventricular walls. The results of various studies show that these changes may vary depending on the type of exercise, age, sex and body surface area (14).

The aim of this study was to investigate the interactive effect high interval exercise training and thyme honey extract on glucose and lipide profile of type 2 diabetic male rats.

The statistical population of the present study consisted of male rats.After 20 weeks of dieting with a high-fat diet and then intraperitoneally injected with a low dose of 25 mg of STZ per kilogram of weight. rats with fasting glucose between 150 and 400 mg / dL were considered type 2 diabetic rat.Diabetic rats divided In 4 groups of diabetic control (6 heads), HIIT (8), thyme honey (6), HIIT and thyme honey (8 heads), HIITand HIIT- thyme honey were performed Eight-week aerobic exercise program, five sessions per week in the 2-minute HIIT with 80 to 90 % Vo2max and a one-minute break with 50 to 56% vo2max. Thyme honey Gavage was administered orally with a 3 g / g 5 days a week during the protocol. At the end of the training period, the rats were anesthetized by Ether and sacrificed. Glucose and lipide profiles were measured using the autoanalyzer. Statistical analysis was performed using SPSS22 software and two-factor analysis of variance and effect size and Bonferoni post Hock test for determination to compare the effect of independent variables.

The research findings showed that the LDL, TG, CHOL of lipid profile in the HIIT group and thyme honey compared to diabetic control decreased, and TG significant decreased in the HIIT (P=0.01). Also, HDL in the group of HIIT and thyme honey and the interaction of HIIT-thyme honey compared to control had a significant increase.

Therefore, it was concluded that the interactive effect of HIIT and consumption of thyme honey has been effective in improving glucose and fat profile.

Aging is a process in which structural and functional changes occur in the heart. This study was performed to compare aerobic and resistance training on some oxidative markers and TGF-β in cardiac tissue of elderly rats.

For this experimental study, 27 Wistar rats (mean age 24 months) were randomly divided into three groups of control (9 rats), resistance training (9 rats) and endurance training (9 rats). After one week of endurance training, rats in the endurance group performed their training on a zero-degree steep treadmill for 8 weeks and 2 days a week. Resistive exercise group also performed on the ladder for eight weeks and seven days a week. The research variables were measured by ELISA using Zellbio Germany kits. Data were analyzed using one-way analysis of variance.

In the present study, it was found that the effect of eight weeks of aerobic and resistance training on GPX (p=0.005), SOD (p=0.002) and TGF-β (p=0.005) was significant in the heart tissue of elderly rats. As a result of the post hoc test, it was found that there was only a difference between the experimental and control groups.

The results of this study indicate the role of aerobic and resistance training in improving oxidative stress indices in the heart tissue of elderly rats.

Obesity increases the risk of developing type 2 diabetes with regard to the hormones involved. The purpose of this quasi-experimental study was to investigate the effect of aerobic exercise on Dpp-4 and GLP-1 in obese women with type 2 diabetes.

From among obese women with type-2 diabetes mellitus 35-50 years old referred to the Diabetes Association of Saveh, 20 people were voluntarily selected and randomly assigned to two groups of control (10) and Experiment group (10) were divided. Twenty four hours before the beginning of the training, the individual characteristics of the subjects included age, height, weight, body mass index and research variables (insulin resistance, Dpp-4 and GLP-1) in the pre-test and the training group Aerobic exercise lasted for 8 weeks, 3 sessions per week, and 45-60 minutes each session, and the control group did not practice. After 8 weeks and 24 hours after the last training session, the individual characteristics and variables of the research were again measured. Data were analyzed by independent t-test and dependent t-test at p≤0.05.

There was a significant increase in the level of GLP-1 (P= 0.001) and a significant decrease in DPP-4 level (P= 0.001) in the aerobic exercise group compared to the control group.

Results showed that Dpp-4 and GLP-1 values were significantly different in aerobic training group after 8 weeks compared to control group. It was also found that aerobic training significantly increased the level of GLP-1 and decreased the level of DPP-4.

Inadequate awareness and knowledge exists regarding the effects of stimulant drugs on renal health among athletes. The present study aimed to determine the effects of methylphenidate, as a stimulant drug, and aerobic exercise on renal function in rats. Eighty male rats were randomly divided into 8 groups (n=10 per group) including control (Co), aerobic exercise sham (AE Sh), drug sham (D Sh), aerobic exercise (AE), the effective dose of drug (ED, 10 mg/kg), 3 times of effective dose (TED, 30 mg/kg), aerobic exercise-effective dose (AE-ED), and aerobic exercise-three times of effective dose (AE-TED). The drug was orally administrated to the animals, and then they were placed on a rat treadmill after 30 minutes. The physical activity (25 m/min) was performed 30 minutes a day, 3 days a week for two months. Twenty-four hours after the last session of AE, blood samples were taken from the rats and serum creatinine (Cr) and blood urea nitrogen (BUN) were determined. The results showed that serum Cr and BUN levels were not significantly different in the exercise group compared to the control groups (i.e., Co, AE Sham, and D Sham). However, serum BUN and Cr significantly increased in the AE-ED and AE-TED groups compared to the AE group (PCr=0.001 and PBUN=0.001). In general, significant increases in the serum BUN and Cr levels in rats received methylphenidate indicated decreased renal function in these animals.

Aerobic exercise increases the production of free radicals. Grape seed extract has a high potential in removing the free radicals. The aim of this study was to determine the effect of concurrent aerobic training and grape seed extract on total antioxidant capacity and malondialdehyde in young men.

In this study, 40 healthy non-athlete male with an average (age 22.60±0.98 in years, weight 76.07±5.11 in kg and body fat 18.06±1.64 in percent) randomly divided into four groups of training- supplement (n=10), training-placebo (n=10), supplement (n=10) and control (n=10). Before and after the intervention, weight, BMI, and body fat percentage, maximum oxygen consumption, total antioxidant capacity and malondialdehyde were measured.

The mean age, weight, and body fat were 22.60±0.98 years, 76.07±5.11 kg, and 18.06±1.64 percent, respective) The results showed that concurrent aerobic training and grape seed extract significantly increased total antioxidant capacity and reduced malondialdehyde in the training-supplement, training-placebo and supplement groups,and in the control group was significantly increased malondialdehyde.

The results showed that 8 weeks aerobic training and consumption of grape seed extract increased total antioxidant capacity and reduced the malondialdehyde.

Type 1 Diabetes is an autoimmune disorder which makes disorder in body metabolic activities. As herbal medicines have fewer side effects than many chemical medicines for treatment of the disease, aim of present study was to review the effect of swimming training and Aloe vera extract on lipid profile of diabetic rats.
In this experimental research, 28 male rates selected and divided into 4 equal groups of control, swimming training, Aloe vera extract and swimming training with Aloe vera extract. Swimming training progressively started in first week by 6 minutes and increase to 36 minutes in sixth week. Groups 3 and 4 received 300 mg/kg peritoneal Aloe vera extract daily.
Findings: Swimming training, Aloe vera extract and their combination had significant effects on improvement of lipid profile of diabetic rats (P Swimming training with Aloe vera extract has interactional effect in improvement of lipid profile of diabetic rats.

Decreased physical activity and blood pressure both are risk factors for cardiovascular diseases. Aerobic training and grape seed extract has a very high potential in reducing or inhibiting of blood pressure and double product. The aim of this study was to determine the effect of aerobic training and grape seed extract on some cardiovascular functional indexes in non-active men.
40 healthy untrained male students with a mean age of 22.60 ± 0.98 years, mean weight of 76.07 ± 5.11 kg and body fat of 18.06 ± 1.64 percent were divided randomly in 4 equal groups of training-supplement, training-placebo, supplement and control. Aerobic training program consisted of three sessions of running per week with the target of 60-85 percent heart rate for 8 weeks. Before and after the intervention, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and rate-pressure product (RPP) were measured. Data were statistically analyzed using one-way ANOVA and post-hoc Tukey methods.
Findings: Aerobic training along with grape seed extract consumption significantly reduced heart rate, systolic blood pressure and RPP in training-supplement and supplement groups (P 0.05). However, no significant change was observed in the control group in any of the parameters (P> 0.05).
The results showed that 8 weeks of aerobic training either alone (training-placebo) or in combination with grape seed extract (training-supplement) and grape seed extract alone consumption (supplement), reduce cardiovascular functional indexes in non-active men.

Cardiorespiratory endurance and resting heart rate is the proper guide for cardiorespiratory fitness of people. The aim of this research was to survey the effect of training intensity and volume changes on cardiorespiratory endurance and resting heart rate. Forty-five non-athletic healthy B. Sc male students (with an average age of 25±1/87 years, weight 71±1/95 kg and height 175±2/30 cm) were randomly divided into three groups including: 1G, 2G and 3G groups. In first six weeks, 1G (n=15) run for 15 min with an intensity of 70% maximum reserve heart rate (MRHR), 1day/week; 2G (n=15) (at 15 min, 60% MRHR, 2 days/week); and 3G (n=15) (at 15 min, 50% MRHR, 3days/week) for 8 weeks. At the last two weeks, 1G run at 75% MRHR, 2G at 65% MRHR, and 3G at 55% MRHR. Findings showed that there was a significant difference in vo2max change in 1G and 3G groups. Also, 3G showed a more significant reduction in resting heart rate than 1G. Based on these findings, it seems that aerobic training with low intensity and long period has more effects on cardiorespiratory fitness and resting heart rate than high intensity and short period training.