hossein fasihi

This study analyzed the credibility perceptions from the perspective of Allameh Tabatabai, one of the prominent Iranian philosophers in the field of philosophy of ethics. Tabatabai emphasizes the significance of credibility based on fundamental values such as truth and justice, arguing that credibility should be rooted in these values. He also pays attention to the analysis of credibility perceptions and underscores their importance in human behaviors and decision-making. The study further delved into how individuals’ credibility perceptions are formed and highlighted the significance of grounding these perceptions on rational arguments, as well as religious and mystical experiences. Credibility perceptions play a crucial role in shaping ethical values and principles and have a direct impact on human ethical behaviors. Moreover, Tabatabai emphasizes the importance of willpower, faith, and piety in shaping human ethical behaviors, explaining that, for individuals to achieve their goals, they must possess knowledge and awareness and make decisions to perform actions based on precise knowledge. These credibility perceptions not only play a vital role in human interaction with the material world but also contribute to the formation of their ethical cognition. Finally, the study demonstrated that analyzing credibility perceptions and focusing on ethical principles and values can contribute to the establishment of suitable ethical environments required for the formation of ethical behaviors. In other words, this study considered credibility perceptions as a solution to addressing ethical challenges in societies and cultures

The present review aims to examine the use of carbamazepine (CBZ) in plasma based on various techniques, such as high-performance liquid chromatography (HPLC) and chromatographic analysis. The review considered in this research is narrative, which is based on previous studies. The effects of CBZ in treating seizures and epilepsy are investigated comprehensively. Accordingly, the related studies regarding the effects of CBZ in plasma based on HPLC were investigated in detail. Due to the findings given in the previous studies, it was revealed that the effects of CBZ are positive and negative for people's health. Due to the obtained results, micellar electro-kinetic chromatography (MEKC) is used for specifying CBZ. Furthermore, the benefits of single reference HPLC are well documented in the literature for therapeutic drug monitoring (TDM) of phenytoin (PHT) and CBZ in plasma. Notably, the use of metal analysis was useful for indicating the positive effect of CBZ in the epilepsy treatment. The combination of chlorpromazine (CPZ) with other drugs can prevent its adverse effects and make it more popular in medicine. The prevention of seizure progression and epilepsy using the CBZ and its counterparts is still a controversial issue that should be tackled in the future.

Valproic acid (VPA), a branched short-chain fatty acid and histone deacetylase (HDAC) inhibitor, has diverse biological activities in human cells, including anti-cancer properties.

In the present study, we tested the cytotoxicity of VPA on the proliferation, cell cycle, and apoptosis of the human cervical cancer cell line, HeLa.

HeLa cell line was cultured in Dulbecco’s modified eagle medium (DMEM) and the cytotoxicity effect of VPA (at 0 - 100 mM) on the HeLa cell was evaluated, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for 3 incubation times (24, 48, and 72 h). The effects of VPA on cell cycle arrest and apoptosis were evaluated, using flow cytometry. In addition, the alterations in the expression of Bax, Bcl-2, p53, and p21 were assessed with real-time polymerase chain reaction (PCR).

Valproic acid reduced the viability of HeLa cells in a concentration- and time-dependent manner, and the IC50 values at 24, 48, and 72 h were 32.06, 21.29, and 14.51 mM, respectively. Further, VPA treatment remarkably increased the apoptosis of HeLa cells and arrested cells at the sub-G1 phase with a significant reduction in G2-M phase populations. The real-time PCR results demonstrated a significant increase in the expression of pro-apoptotic genes, including Bax, p53, and p21, as well as a reduction in the levels of the anti-apoptotic gene, Bcl-2.

Valproic acid inhibits the proliferation of the HeLa cell line through the induction of the intrinsic pathway of apoptosis in a p35-dependent manner.

The COVID-19 pandemic has prompted researchers to find treatments and vaccines to control SARS-CoV-2. There are some hypotheses about the benefit of respiratory virus vaccines, like MMR, for COVID-19 pneumonia severity, morbidity, and mortality. The influenza vaccine is one of the most frequently used respiratory virus vaccines covered by one of the Iranian insurance institutes. We have a symmetrical group of participants that have received this vaccine that could be compared with each other. We compared 3,379 persons aged 20 - 75 years for the effect of the influenza vaccine on COVID-19 mortality. We ultimately found that it does not affect mortality caused by COVID-19 pneumonia, but it can decrease the hospitalization cost in people over 65 years with a history of chronic disease.