فهرست مطالب jamileh saremi

Kidneys are critical in the clearance and maintenance of active metabolites. One of the medical properties of Salep is treating bladder and kidney inflammation. Due to the widespread use of Salep in traditional medicine and the food industry, and since the effects of Salep on kidney function have not been studied, the present study aimed to investigate the impact of Salep on kidney function. In this experimental study, 48 male rats were divided randomly into six groups as control, sham, and four experimental groups receiving different doses of Salep intraperitoneally (80, 160, 320, and 640 mg/kg). On day 29, after weighing the animals, blood samples were taken from the heart, and serum blood urea nitrogen (BUN), uric acid, and creatinine were analyzed and compared in different groups. All the animal’s kidneys were exposed after dissection, and tissue sections were prepared for histopathological evaluation. From day 28 to 29, rats were kept in metabolic cages to collect urine samples and measure water intake and urine volume. The serum concentration of BUN and uric acid in the groups receiving Salep at all doses decreased non-significantly compared to the control group. Furthermore, a significant reduction was seen in creatinine serum levels in groups receiving 320 and 640 mg/kg of Salep extract (P<0.05). No evidence of damage to renal tissue was observed in this study. In conclusion, Salep could decrease serum BUN, uric acid, and creatinine levels due to its antioxidant properties and had no devastating effect on kidneys.

Checking the quality of meat products is very important. The purpose of this research is to investigatethe presence of unauthorized tissues in this product to improve its quality and safety level and promote the health of society. In this cross-sectional descriptive study, sausages with meat percentages of 40, 55 and 70 wererandomly purchased from three factories (10 pieces each) and divided into three pieces and then three slides from each piece with hematoxylin-eosin method was prepared (270 slides in total). Finally, 10 microscopic fields were examined from each slide. The data were analyzed by using SPSS software. At the level of less than 0.05, the difference between the groups was considered significant and the results were shown as Mean ± SD. Furthermore, the frequency percentage of tissues in each of the sausages was calculated. Cartilage tissue, bone, skin, kidney, salivary gland, blood vessel, abdominal viscera and plant tissues were observed in all meat products. However, central nervous system and spleen tissues were not seen in any of the samples. In sausage 40%, the highest frequency percentage of tissue was related to skin, in sausage 55%, skin and kidney, and in sausage 70%, kidney. In addition, the amount of illegal tissues was different in 40%, 55% and 70% sausages and this difference was significant in many tissues. By using histological methods, it is possible to detect illegal tissues in meat products and obligate factories to comply with the national standard.

Nephrolithiasis is a common urinary tract disease, in addition to the pain and treatment costs, there may be significant complications resulting from the stones. This study intended to investigate the effects of Polygonum Aviculare L. aqueous extract (PAE) on urolithiasis induced by ethylene glycol (EG) and ammonium chloride (AC) in rats.

Sixty-four male Wistar rats were randomly divided into eight groups (n = 8). Rats in the normal control group (I) received no treatment. The sham groups (III and IV) were given PAE. at 100 and 400 mg/kg by gavage for 28 days. The disease control group (II), the prevention groups ( V and VI), and the therapeutic groups (VII and VIII), received 1% EG and .25 AC in their drinking water for 28 days. The prevention groups (from the start of EG administration), and the therapeutic groups (from the 14th day of EG administration), received PAE at 100 and 400 mg/kg by gavage. At the end of the experiment, kidneys were examined for CaOx deposits and tubulointerstitial changes.

The number of CaOx crystals and tubulointerstitial changes increased significantly in group II rats compared to groups I, III, and IV (P

Results show aqueous extract of Polygonum Aviculare L. is effective in the prevention and treatment of kidney stones.

The aim of this study was to investigate the anti-urolithiasis effects of aqueous extracts of Malva neglecta Wallr on ethylene glycol and ammonium chloride induced kidney stones in a rat model. A total number of 64 male Wistar rats were randomly divided into eight groups equally: group I (normal control), group II (disease control), groups III and IV (sham), groups V and VI (preventive groups), and groups VII and VIII (curative groups). Group I received tap drinking water, groups III and IV were given intra-peritoneal injections of 200 and 800 mg/kg aqueous extracts for 28 days. Groups II, V, VI, VII, and VIII received 1% ethylene glycol plus 0.25% ammonium chloride in drinking water for 28 days. Groups V and VI were given intra- peritoneal injections of 200 and 800 mg/kg aqueous extracts for 28 days and groups VII and VIII received intra-peritoneal injections of 200 and 800 mg/kg aqueous extracts from the 14th day of the experiment. After 28 days the kidneys were removed and observed for calcium oxalate (CaOx) deposits and tubulointerstitial changes. The extract significantly decreased CaOx deposits and tubulointerstitial damage in the preventive groups (P <. 001). In curative groups, a low dosage of extract, reduced kidney oxalate deposits and tubulointerstitial damage (P <. 05). In addition a significant decrease was observed in crystal deposition and tubulointerstitial damage in high dosed group (P <. 001). However, high dosed preventive and curative groups seemed to be more effective (P ≤. 001). Malva neglecta Wallr has beneficial effects on preventing and treating CaOx deposition and decreasing tubulointerstitial damage on a dosage dependent manner. These effects may be due to the components presented in this plant such as saponins, flavonoids, mucilage, and phenolic compounds.

Endometrial remodeling occurs during each menstrual cycle in women. Reports have shown that, in a variety of cell types, processes such as proliferation, signaling complex formation and extra cellular matrix remodeling require a cytoplasmic tyrosine kinase, focal adhesion kinase (FAK). The present study has focused on the expression pattern of FAK in human endometrium during the menstrual cycle. The purpose of this study was to ascertain the probable function of FAK in menstrual cycle changes and the role of FAK in tissue repair and tissue remodeling in vivo. Formalin-fixed paraffin-embedded endometrial samples were obtained from 400 pre-menopausal, non-pregnant women, who underwent hysterectomy and biopsy for benign diseases. Forty six samples with no tissue abnormalities were studied and ABC staining method of immuno-histochemistry methods was applied. Positive staining of FAK by different cell types of human endometrium was scaled and compared with each other by using histologic score method. All different cell types of endometrium showed various patterns of FAK expression in different stages of menstruation. FAK in glandular and luminal epithelial cells is up-regulated during the early proliferative (EP) to mid-secretory (MS) phases. FAK in stromal cells is up-regulated during the EP, early and MS phases in comparison to the late secretory (LS) phase. FAK expression in endothelial cells is up-regulated during the EP and MS phases in comparison to LS phase. This study showed that endometrial FAK expression is a phase-dependent manner during the menstrual cycle. It appears that up-regulation of FAK during the proliferative phases is responsible for endometrial regeneration and high expression of FAK in the EP and MS phases may associate with the implantation. Down-regulation of FAK during the LS phase may facilitate apoptosis in human endometrium. It seems that FAK as a key kinase plays a critical role in endometrial remodeling that it may regulate by steroid hormones