فهرست مطالب lilik kartikasari

Diabetes mellitus (DM) is a non-communicable disease that is generally associated with fasting blood glucose (FBG) level of >126 mg/dL and weight loss. Germinated black rice krisna (GBRK) extract contains phytochemicals with antioxidant and anti-diabetic properties. The purpose of this study was to assess the impact of GBRK extract on FBG level and body weight (BW) in rat model of DM. In an in vivo pre- and post-test study 36 male Wistar rats with BW design, of 150-200 g were enrolled and divided into 6 groups, including control (C), negative control (NC), GBRK 535 mg/kg BW (P1), GBRK 1070 mg/kg. BW (P2), and GBRK 2140 mg/kg BW (P3). Diabetes was induced using streptozotocin (STZ) and nicotinamide (NA) and the intervention period was 14 days. Measurement of FBG level was by quantitative enzymatic colorimetric test of Glucose Oxidase Phenol 4-Aminoantipyrine (GOD-PAP) and body weight was determined by a digital scale. The administration of GBRK extract in P1, P2, and P3 groups could significantly reduce the FBG (p <0.01). GBRK in P1, P2, and P3 groups could also significantly improve the body weight to normal state too (p <0.01). GBRK extract at doses of 535, 1070, and 2140 mg/kg BW for 14 days was demonstrated to improve metabolic disorders in diabetes by reducing FBG level and improving the BW to the normal state.

Okra (Abelmoschus esculentus) is a vegetable with fiber, vitamin C and flavonoids that can delay emptying of the stomach and cause longer satiety based on the fiber contents so that calorie intake is reduced. The presence of vitamin C and flavonoids in okra acts as an antioxidant that can fight free radicals and detain oxidative stress caused by hyperglycemia. This study aimed to compare the effect of steamed and  boiled okra on fasting blood glucose levels in patients of type 2 diabetes mellitus with hypercholesterolemia.  The independent variables consisted of steamed and boiled okra and the dependent variable was fasting blood glucose level. Forty patients who suffered from type 2 diabetes mellitus and with hypercholesterolemia were enrolled and divided into three groups including the control group (G1), treatment group of G2 (boiled okra intervention as much as 40 g for 14 days) and G3 (steamed okra intervention as much as 40 g for 14 days).  A greater decrease in fasting blood glucose level was noted for boiled okra group when compared with steamed okra group among patients suffering from type 2 diabetes mellitus and with hypercholesterolemia.  Administration of boiled and steamed okra as much as 40 g for 14 days was shown to reduce fasting blood glucose level among patients suffering from type 2 diabetes mellitus and with hypercholesterolemia.