فهرست مطالب m. ghahremani

Vascular endothelial growth factor (VEGF) as the strongest and most important stimulant of angiogenesis increases the migration and proliferation of endothelial cells and vascular network formation. The expression of this protein in hypoxia conditions is increased and stimulates angiogenesis by increasing the expression of hypoxia-induced factor (HIF-1). The aim of the present study was to determine the effect of eight weeks of moderate intensity endurance training on the expression of HIF-1 and VEGF genes in the heart muscle of male rats with myocardial infarction.

In the present experimental study conducted in 2019, 16 Wistar male rats of 10 weeks old and mean weight 250-300gr were allocated to two groups of Exercise (60 minutes of interval treadmill running for four minutes with the intensity of 65-70 and two minutes of active rest at 50-60 percent of VO2max for 5 days a week for 8 weeks) and control group (without any training). Real-time PCR was used to assess the expression of genes. Data were analyzed in SPSS18 using independent t test (P≤ 0.05).

The results of independent t-test related to experimental and control groups in VEGF and HIF-1 cardiac muscle index indicated that VEGF in the exercise group was significantly higher than the control group (p = 0.001) and also HIF-1 in the exercise group. It was significantly higher than the control group (p = 0.001).

In general, eight weeks of moderate intensity endurance training increases the effective factors in angiogenesis in male Wistar rats after myocardial infarction. Hypoxia resulting from eight moderate intensity endurance training increases HIF-1 and on the other hand this protein increased the expression of VEGF gene, which is the most important stimulator of angiogenesis, and ultimately increased angiogenesis in the heart muscle.

Most organizations are unable to share knowledge and intellectual capital effectively, thus they sustain much loss which can be prevented through knowledge sharing. Effective knowledge sharing requires the appropriate cultural setting. Research shows that organizational culture is one of the most important factors in helping or otherwise retarding knowledge management and knowledge sharing.Therefore, this research focuses on the relationship between organizational culture and activities related to knowledge sharing among faculty members of Jihad-e Daneshgahi (Academic Defense). The method is of combined correlation studies type, and data gathering technique is the questionnaire. The sample consists of 280 of faculty members who have been selected through proportional stratified sampling method. Results show that an organizational culture which promotes participatory, flexible (innovative) and missionary-devotee elements has a positive relationship with knowledge sharing among the faculties. Yet no significant relationship was found between a stability-based culture and knowledge sharing process. The results also show that the relationship between organizational culture and knowledge sharing can be moderated by the way in which knowledge is shared.