mohammad rasool ghadami

Preeclampsia is one of the complications of pregnancy period that threatens the life of both mother and fetus. Various studies have shown that platelets play a major role in the pathogenesis of preeclampsia. The aim of this study is to compare platelet indices in preeclamptic and normal pregnant women and to evaluate whether these parameters have a predictive significance in determining the severity of preeclampsia. This case-control study was held on pregnant women who referred to Imam Reza Hospital of Kermanshah city for delivery from 2008 to 2010. Participants were classified into three groups of mild preeclamptic (57 person)، severe preeclamptic (50 persons)، and normal pregnant women (102). Under standard conditions، 5 ml of individual''s venous blood of each group was taken prenatally. Automated blood cell counter XT-1800 was used to measure platelet indices that include platelet number، mean platelet volume (MPV)، Platelet distribution width (PDW)، and Platelet large cell ratio (P-LCR). Data analysis was performed by using ANOVA، SPSS statistical software version 16. Tukey test was used to assess differences between groups. P value less than 0. 05 was considered statistically significant. There was no statistically significant difference in platelet number and indices between preeclampsia and healthy pregnant women. (P>0. 05) As a result، no significant difference of platelet number (Pand indices was observed in patients with preeclampsia (P>0. 05). The results showed that platelet indices were not affected by preeclampsia during pregnancy. Also، no difference was observed in the term of platelet number and indices in mild and severe preeclamptic cases.

Objective(s)Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats.Materials and MethodsMale rats were studied in two groups; the first group received different intraperitoneal (i.p.) sodium salicylate doses (0, 200, 300, and 400 mg/kg) and the second group received intra-hippocampal doses of the drug (0, 30, 50, and 100 μg/0.5 μl/side). The spatial performance of rats was tested using Morris water maze (MWM) task. The spatial learning and memory parameters were analyzed using ANOVA.ResultsPeripheral and intra-hippocampal administration of sodium salicylate did not lead to a statistically significant change in the mean time (escape latency), and also the distance traveled for finding the hidden platform during the training days, compared with the control group. But at the probe trial, the percentage of time spent in the target quadrant by rats which received the highest doses of drug significantly increased. ConclusionWe found that both peripheral and intra-hippocampal administration of sodium salicylate facilitates the process of spatial memory consolidation in the MWM.

Cyclooxygenase (COX) enzyme known as a regulatory factor in synaptic plasticity. It has been reported that synaptic plasticity is one of the mechanisms involved in learning and memory processes. In the current study peripheral injection's effects of sodium salicylate (as a non selective COX inhibitor) on spatial learning and memory have been investigated. Four groups of male rats received different doses of sodium salicylate (0, 200, 300, 400 mg/kg; i.p.). Studies were performed using Morris Water Maze (MWM). Spatial learning and memory parameters were subjected to the one- and two-way analyses of variance (ANOVAs) followed by Tukey’s post hoc test. Data showed that intraperitoneal injection of sodium salicylate had not significant effect on spatial learning parameters (including escape latency and traveled distance to hidden platform in training days); but administration of high dose of the drug (400 mg/kg) significantly increased the percentage of time that animals spent in the target quadrant in probe trial testing. Peripheral injection of the COX inhibitor has no significant effect on spatial learning; but potentiates spatial memory consolidation using MWM.