mojgan hajahmadipour rafsanjani

This study aimed to investigate the relationship between left ventricular diastolic function, longitudinal myocardial strain, and echocardiographic parameters in diabetic patients. This cross-sectional analytical study included all eligible type 2 diabetes patients referred to Seyed al-Shohadah Hospital, Urmia, Iran from March 2021 to February 2022. All the participants had an echocardiography examination. Demographic characteristics including age, sex, duration of diabetes, smoking, and body mass index (BMI) were recorded at the time of the echocardiography examination. This study included 140 participants, 70 were diagnosed with type 2 diabetes mellitus (T2DM) and 40 were considered healthy control group. The mean age of participants was 47.79±7.08 years for diabetics and 47.23±6.5 years for controls. A significant correlation was observed between diabetes duration and the echocardiography values of E/e', DT, MPI, and D (p < 0.05). A significant correlation was observed between DT (p=0.021), IVPT (p=0.037), TRvel (p=0.002), and a-sep values (p< 0.001) and smoking in diabetic patients, with a negative correlation. Moreover, a statistically significant positive association was established between E/e´ (p=0.043), e' (p=0.007), e-lat (p=0.046), e-sep (0.003), and a-lat (p=0.003) values and smoking in diabetic patients. Furthermore, GLS scores and diastolic dysfunction exhibited a statistically significant association with smoking and BMI variables. This study demonstrated a statistically significant association between diastolic dysfunction and global longitudinal strain (GLS) in both diabetic and control groups. This suggests that GLS can be utilized to assess the severity of diastolic dysfunction in diabetic patients during the early stages of heart failure.

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Bendopnea, defined as dyspnea while bending, can be observed in patients with heart failure (HF). In this study, we investigated the frequency of this symptom in patients with systolic HF and its association with echocardiographic parameters.

In this study, patients with left ventricular ejection fraction (LVEF) ≤45% and decompensated HF referred to our clinics were prospectively recruited. All patients were examined by cardiologists for collecting data on the presence of bendopnea and baseline characteristics. They also underwent electrocardiographic and echocardiographic examinations. All findings compared between patients with or without bendopnea.

A total of 120 patients with a mean age of 65.19 ± 12.62 years were evaluated, and 74.8% were men. Bendopnea was observed in 44.2% of the patients. The etiology of HF was ischemic in most patients (81.9%), and the functional class of most patients (85.9%) was III or IV. The mortality rate at 6 months follow-up was comparable between patients with or without bendopnea (6% vs. 9.5%, p=0.507). The waist circumference (odds ratio [OR] 1.037, 95% confidence interval [CI] 1.005 – 1.070, p = 0.023), paroxysmal nocturnal dyspnea (OR 0.338, 95% CI 0.132 – 0.866, p = 0.024), and right atrium size (OR 1.084, 95% CI 1.002 – 1.172, p = 0.044) were associated with bendopnea.

Bendopnea can be frequently found among patients with systolic HF. This phenomenon is associated with obesity and baseline symptoms of patients and right atrium size upon echocardiographic examinations. It can help clinicians with the risk stratification of HF patients.

Background and Prevalence of overweight and obesity caused by a sedentary lifestyle and poor diet is the problem of health that one of its side effects is Non-Alcoholic Fatty Liver Disease (NAFLD). The aim of this study was to investigate of tissue and blood indices of liver and metabolic syndrome in patients with nonalcoholic fatty liver during a period of exercise training.
In this randomized controlled trial, 29 overweight and obese women with liver steatosis with an age range of 22 to 52 years, were randomly divided into two groups: aerobic exercise (n = 13) and control (n = 16). Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate). The control group was sedentary during the same period. Blood samples to determine levels of liver enzymes (SGOT, ALK, SGPT) and serum lipid profile (TG, CHO, HDL, LDL) were collected before and after the test. Data were analyzed using SPSS version 21.
The results show significant changes of anthropometric parameters (waist circumference) and biochemical variables (ALK and total cholesterol) between the two-experimental and control groups(p≤0/05).
Due to significant changes in a few indicators of the study, 12 weeks of aerobic exercise seems to be at least appropriate way to manage and control the fatty liver and its complications.