molanouri shamsi

Obesity is a state characterized by a low-grade inflammation that leads to insulin resistance. The aim of the present study was to assess serum interleukin-18 (IL-18), interleukin-6 (IL-6), C-reactive protein (CRP) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in response to circuit resistance exercise in obese and normal-weight subjects with different levels of physical activity. Thirty-two healthy male students participated in the present study. Subjects were divided into 4 groups according to their BMI and level of physical activity: active obese (n=8), active non-obese (n=8), inactive obese (n=8), and inactive non-obese (n=8). To determine serum IL-6, IL-18, CRP, glucose and insulin concentrations, fasting and post-exercise blood samples were obtained. Subjects performed a bout of circuit resistance exercise in 2 sets with 10 repetitions at 60% of 1RM. Obese subjects comparing non-obese ones showed significant increase in IL-6 and significant decrease in IL-18 concentrations in response to exercise (p<0.05). There was no significant difference between active normal and inactive normal subjects in response to exercise. Also, there were not significant differences in four groups in response to exercise. The significant decrease in IL-18 concentration in the obese group comparing normal group in response to exercise was probably due to anti-inflammatory effects of exercise. Also, recommending this kind of exercise for obese persons with low level of physical activity can improve insulin resistance.

The purpose of this study was to investigate the effect of active recovery (AR) vs passive recovery (PR) on serum levels of interleukin 6 (IL)-6, IL-8, IL-10 and Creatine Kinase (CK) after eccentric strenuous exercise.

Twenty-eight female students of physical education participated in this study, age (23.8±1.99) years, height 164.03±5.61 cm, weight 58.21 (8.23) kg and fat percent 27.18 (4.86)]. The subjects were randomly divided into two groups and completed a set of strenuous workouts, including a 30 min of treadmill downhill running (-5% grade) at 80-85% of Maximal Heart Rate (MHR), followed by AR for 15 min at 50-60% of MHR, or complete rest in the seated position (PR). Blood samples were collected pre- and post exercise, and after recovery in order to measure the levels of IL-6, IL-8, IL-10 and CK.

Both the AR & PR groups showed increase in the levels of serum cytokines after exercise and recovery, except IL-10 that decreased after exercise. IL-6 levels after recovery were higher in AR. Also, there were significant differences between the two groups after recovery in IL-8 and IL-10.

The results show no significant differences in the levels of IL-6 in either group. It also seems that the post exercise increase in the levels of circulating cytokines is not due to the muscle damage, in spite of the increase in CK indicating that the increase of cytokines after AR is probably because of their anti-inflammatory effects.