فهرست مطالب nader kalbasi

 Artificial Intelligence (AI) is a term that implies using a computer to model intelligent behavior with minimal human intervention. Their potential to exploit the meaningful relationship with a dataset can be used in diagnosis, treatment, and outcome prediction in many clinical scenarios. The aim was to evaluate the use of artificial intelligence algorithms to successfully differentiate histopathologic images of grades of OSCC and healthy oral mucosa.

 In this cross-sectional study, Inception-ResNet-V2, a recently created artificial intelligence system, was used to analyze 844 pictures captured from the histopathological view of the connective tissues from three groups, low-grade OSCC, high-grade OSCC and normal mucosa. 

 The results obtained from this research and comparable articles emphasize that deep learning-based systems have a high ability to analyze histopathological images and can be very useful and effective in cancer diagnosis and grading. According to the results of the ROC analysis from this research, Inception-ResNet-V2 has shown robust results in successfully differentiating Low-Grade OSCC, High-Grade OSCC and normal mucosa with over 95% accuracy.

 According to the results of the present and previous studies, it can be concluded that CNN, and particularly Inception-ResNet-V2 have immense potential in analyzing histopathology pictures and could be very helpful for pathologists in cancer diagnosis.

Silver and zinc oxide (ZnO) nanoparticles have recently become common to coat ligatures in order to take advantage of positive properties of nanoparticles, although there are concerns about their cytotoxicity. This study tended to compare subcutaneous inflammatory response induced by elastomeric orthodontic ligatures coated with silver and ZnO nanoparticles with a control group in rats.

In this in vitro and animal cross‑sectional descriptive‑analytical study, silver nanoparticles were synthesized by chemical reduction of silver nitrate solution in the presence of sodium borohydride and ZnO nanoparticles by the same method and by chemical reduction of zinc sulfate solution with sodium hydroxide and were coated on elastomeric ligatures. Subcutaneous inflammation degrees were assessed after 15 and 30 days and were compared in the groups by Kruskal–Wallis test and ordinal generalized estimation equation with exchangeable correlation matrix. All tests were performed with a significance level (P = 0.05).

There was a significant difference in terms of degrees of inflammation in the groups coated with ZnO nanoparticles (P = 0.003) and silver nanoparticles (P = 0.04) compared to the control group in 15‑ and 30‑day samples. Zinc nanoparticles caused 3.22 times more inflammation than silver nanoparticles (P = 0.053). The decrease in inflammation was significant over time in all groups (P = 0.001).

There was a significant more inflammation in the groups receiving ZnO and silver nanoparticles compared to the control group in 15‑ and 30‑day samples. Silver nanoparticles are probably safer than zinc nanoparticles for tissue and a better material to choose for antibacterial effects.

Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%–10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health‑care workers.

This was a descriptive study which was implemented among 140 of medical and dental staff working as health‑care workers who were low responder after vaccination entered the study.

Age (>40 years), weight (body mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and smoking were the important factors.

In the high‑risk group of hepatitis B disease, the risk factors of immunogenicity must be evaluated at vaccination and check titers of antibody after vaccination.

FDBA, DFDBA and PARTIAL allografts are widely used as bone substitute materials. The aim of this study was to histologically compare the regenerative features of these three types of allografts manufactured by Kish Hamanandsaz Company in Iran. In this experimental animal study, four bone defects with a diameter of 8 mm and a depth of approximately 1 mm were produced in the calvaria of 8 rabbits (4 defects in each rabbit) by trephine. In three defects, three types of allografts, i.e. FDBA, DFDBA and PARTIAL, were placed and one defect served as a control. One of the rabbits died 5 days after surgery. Histological samples were prepared after 4 weeks. Percentages of new bone formation and the remaining materials and inflammation were evaluated. Data were analyzed with Friedman and Cochran tests, using SPSS 22 (α = 0.05). There were significant differences between the four groups (DFDBA, FDBA, PARTIAL and control) in mean percentages of new bone formation (p value = 0.001) and mean percentages of remaining material (p value = 0.002). However, there were no significant differences in inflammation between the four groups (p value = 0.572). Despite the difference in numerical values for bone regeneration, there were no statistically significant differences in the amount of bone formation between DFDBA and FDBA groups, but further studies are necessary on PARTIAL allograft

Mastitis is an inflammatory disorder in breast tissues due to bacterial factors, mycobacterial infections or autoimmune diseases. Idiopathic granulomatous mastitis (IGM) is a form of mastitis which may be affected by systematic diseases such as sarcoidosis, and infectious causes such as mycobacterium and fungus. This study evaluates the efficacy of medical therapy with a combination of corticosteroid and Azithromycin in patients with IGM.

This study is a clinical trial research carried out in Alzahra Hospital (Isfahan, Iran) in 2013 on granulomatous mastitis patients. It was administered 250 mg of Azithromycin per 12 hour and 60 mg of Prednisolone per day within 2 weeks. Next, they took 40 mg/day within 8 weeks, and this dosage was tapered during 6 months and the patients clinically and radiologically followed up. The studied patients were examined within 1 week, 2 weeks, 1 month, 3 months, and 6 months, from the beginning of treatment.

This study investigated granulomatous mastitis patients in Alzahra hospital in 2013. The mean age of these patients was 33.6 ± 8.9, and their age range was 18–56 years old. Among 26 studied patients, 24 persons (92.3%) according to follow‑up the patients by physical examination and sonography responded to treatment of corticosteroid and Azithromycin. The remaining (7.7%) underwent surgery. Treatment periods in case of drug use were respectively, 8.5 ± 0.71 months.

Treatment with corticosteroid and Azithromycin is an effective and appropriate treatment for IGM.

Conventional hepatitis B virus (HBV) vaccination fails to achieve efficient protection in about 5–10% of the world population. Hence, different strategies have been adopted to ameliorate HBV antibody titers. This study aimed to evaluate the concurrent application of tetanus‑diphtheria (Td) and HBV vaccination on hepatitis B surface (HBs) antibody titer in low‑responder healthy individuals.
This was a randomized clinical trial, which was implemented among 140 of medical staff working as health‑care workers assumed as low‑responders. The subjects were randomly allocated to either control or interventional groups. The control and interventional groups received HBV recombinant vaccine while the latter group was also vaccinated through Td. Enzyme‑linked immunosorbent assay was applied to measure HBs antibody (HBsAb) titers just before and 6 months after the last vaccination. All data were entered into SPSS software. Independent t‑test, paired t‑test, and Chi‑square or Fisher’s exact test were applied for data comparison.
Antibody titers of the subjects in the intervention and control groups soared from 49.08 ± 20.08 IU/L to 917.78 ± 204.80 IU/L and from 46.95 ± 18.55 to 586.81 ± 351.77 IU/L, respectively (both P Concurrent application of Td and HBV vaccine could effectively enhance protective levels of HBsAb titers in low‑responder individuals.

Hepatitis B virus (HBV) fails to produce appropriate immune responses in some healthy individuals; thus, different strategies have been adopted to promote immune responses. The current study aimed at evaluating the efficacy of HBV vaccine coadministered with tetanus-diphtheria (Td) vaccine compared with HBV vaccine in healthy individuals through measuring hepatitis B surface antibody (HBsAb) levels. This was a randomized controlled clinical trial, which was implemented in Isfahan, Isfahan Province (Iran) in 2013. One hundred and forty healthy individuals, whose HBsAb titers were less than 10 IU/L were recruited. The subjects were randomly assigned to either in intervention or control trials. The control group received 40 µg of recombinant HBV vaccines intramuscularly injected at 0, 1, and 6 months; however, the intervention group was simultaneously vaccinated by Td with the first dose of HBV vaccine. HBV antibody levels (titer) were measured before the vaccination and 6 months after the last vaccination. Antibody titers of the subjects in the intervention and control groups increased from 5.07 ± 2.9 IU/L to 744.45 ± 353.07 IU/L and from 4.45 ± 3.4 IU/L to 589.94 ± 353 IU/L, respectively (both P < 0.001). Also, the mean difference of antibody titer was significantly different between the two groups (P = 0.011). Td vaccination can be applied as a feasible approach to promote efficient and persistent immunity in healthy individuals with insufficient HBsAb titers.