فهرست مطالب navid shahrokhi saboor

ABSTRACT In this experiment, the effect of oral administration of cabergoline, an anti-prolactine drug on induction of fertile estrus in bitches was investigated. For this purpose, fourteen bitches from German shepherd breeds were used in the study at their already determined periods of anestrus. Four dogs formed the control group, while 12 bitches were treatment group. All treatment famales were administered with recommended doses (5ug/day) of cabergoline formulation marketed for use in woman. An aqueous solution of cabergoline (casber, Pharmacia, Italy) was orally administered until 2 days after the onset of proestrus or for a maximum of 41 days. Five hundred IU of HCG was intramusculary administered to four of these dogs on days 1 and 3 of estrus. The remaining 4 dgs were not treated with HCG. Blood samples were taken once from all females during the first days of treatment and then every other day during the beginning the behavioral estrus to measure progesterone concentrations. In the treatment proestrus was incduced between days 18-39 (mean: 5/27±5/5 days), in the ratio of 0/9 (p= 5%>). The mean duration of estrus was recorded in the experimental group (8.6±7.8) days (P<0.05). The pregnancy rate for both groups of dogs was 60%. Puppetry rates were recorded (5.5±0.9) and (4.6±1.8) days (P<0.05) after calving records for HCG+ and HCG- pregnant animals, respectively. The data obtained on the incidence of pregnancy and estrus were evaluated by chi-square test and termination of treatment up to the onset of estrus symptoms by SAS software. The results showed that normal and fertility estrus is achieved using cabergoline and HCG injection has no significant effect on pregnancy rate.

Drug addiction is one of the major concerns of today's society. Drug use causes widespread clinical complications in users. Morphine is a very strong analgesic and narcotic drug that causes biotransformation in the liver, gastrointestinal tract and kidneys and is excreted through the kidneys. This study was performed to evaluate the effect of peritoneal morphine injection in adult male rats in an experimental format based on a completely randomized design with 30 mice in a 28-day breeding period and dividing the mice into control and experimental groups. During the first week of the experiment, all groups used the basal diet to adapt to the conditions of the breeding environment and morphine was then injected daily into the experimental group at a dose (10 mg / kg once daily) for three weeks. At the end of the fourth week, blood samples were taken from the mice after anesthesia, then the mice were killed by amputation of the cervical vertebrae, and after opening the abdominal cavity. The testes and epididymis were removed. Cholesterol, triglyceride, glucose, HDL, LDL, sex hormones (testosterone, FSH, LH) and the number and percentage of sperm survival in the laboratory were determined and the experimental data after normal testing using software SAS was statistically analyzed. The results showed that the effect of peritoneal injection of morphine significantly increased the concentrations of glucose, LDL and testosterone (P <0.05). Also, HDL and triglyceride were not significant on cholesterol concentration but caused a relative increase in cholesterol and a decrease in HDL and triglyceride (P <0.05). It also significantly reduced the number and progress of progress (P <0.05).