فهرست مطالب sadeq

Bone marrow mesenchymal stem cells (BMSCs) are the key to regenerative wound healing. MSCs have spatial memory and respond to local environment. The goal of this study was to evaluate the use of systemic and intralesional transplantation of BMSCs for regeneration of oral mucosa in an in vivo dog model. Transplantation of undifferentiated green fluorescent protein (GFP)- labeled autologous BMSCs systemically, submucosally or vehicle (saline) was injected around the chemically induced oral ulcer in each group of 18 adult dogs. The healing process of the ulcer was monitored clinically and histopathologically. Gene expression of vascular endothelial growth factor (VEGF) and collagen genes was detected in biopsies from all ulcers. One way ANOVA was used to compare between means of the three groups. Results were considered significant at P < 0.05. Flow cytometric analysis of the MSCs at the passage 3 showed that these cells were negative for CD45 (2.39%). They expressed high levels of CD29 (98.34%). Frozen fluorescence microscopy of sections of the cell-treated oral tissue of all groups indicated that the GFP-transduced implanted cells were integrated within the transplanted tissues. The treatment resulted in dramatic wound edge activation and resurfacing of oral mucosa wound. Our results revealed that BMSCs may be labeled with (GFP), in order to know the distribution of these cells after administration, and suggest that intralesional administration is an appropriate procedure to achieve acceptable regeneration of the previously injured oral mucosa more than systemic route.

Taha Hossein, one of the great Muslim scholars of the present century investigated different areas of Islamic thought through scientific method and out-of-religion analysis. He is of salient works in the area of history of Islam. Following the evolutions of the recent two centuries and the collapse of Ottoman emperorship in Arabic countries, it has been made a current emphasizing on Arabic concepts and Arabic race and the followers of this current try to present some reasons for the stability of Umayyad government and the justification of their action. The present research firstly looks for achieving Taha Hossein's approach around bases of legitimacy of a government and secondly, investigating his approach around legitimacy or illegitimacy of Umayyad government emphasizing on Muawiyah himself.