zahra khakzad

 This study aimed to examine the causal pattern of cognitive emotion regulation and impulsiveness with the mediating role of executive functions, working memory, and stress coping strategies in female students with conduct disorder.

Methods and Materials: 

This study can be examined from two perspectives: from the perspective of implementation method, it falls under descriptive research of a predictive correlational type, and from the perspective of purpose, it is considered applied research. The statistical population of this study included all first-year high school female students in the city of Kermanshah in the academic year 2022-2023, from which 200 individuals were selected as the sample. A simple random sampling method was used. In the data collection domain, both library and field methods were employed. In the field section, for collecting the necessary research information, the following questionnaires were used: Behavioral Problems of Quay and Peterson (2013), Emotion Regulation of Gross and John (2003), Impulsiveness of Barratt (1995), Behavioral Rating Inventory of Executive Functions of Gioia et al. (2000), Working Memory of Daneman and Carpenter (1980), and Coping Strategies of Moos and Billings (1981). Subsequently, SPSS22 and PLS statistical software were used for data analysis.

 The study results indicated that cognitive emotion regulation affects the impulsiveness of female students with conduct disorder. Executive function affects the impulsiveness of female students with conduct disorder. Working memory affects the impulsiveness of female students with conduct disorder. Stress coping strategies affect the impulsiveness of female students with conduct disorder.

 The results showed that cognitive emotion regulation affects the impulsiveness of female students with conduct disorder with the mediation of executive function. Cognitive emotion regulation affects the impulsiveness of female students with conduct disorder with the mediation of working memory. Additionally, the results indicated that cognitive emotion regulation affects the impulsiveness of with the mediation of stress coping strategies.

Phenylketonuria is a type of congenital and genetic metabolic disease of autosomal recessive type, which due to the deficiency or lack of phenylalanine hydroxylase enzyme, the amino acid phenylalanine is not converted to tyrosine and causes an increase of phenylalanine in the blood, especially in the brain, and as a result, causes irreversible complications including irreversible mental retardation. The aim of this study was to investigate the IQ of children with phenylketonuria identified in the national PKU screening program for children over 5 years of age.

This cross-sectional study was conducted in the pediatric center of Shahid Motahari hospital in Urmia during 2011-2014. The participants in this study were selected from children with phenylketonuria who referred to the pediatric clinic of Shahid Motahari Hospital in Urmia and were included in the study. Twenty-five children were included in the study using the full number method, and the required information was extracted from the patients' files and analyzed.

The mean age of the studied children was 6.32±4.33 years and the average age of diagnosis was 30.28±52.24 days. The mean level of phenylalanine mg/dl was 5.40±4.33 and the mean IQ was 93.56±12.99. The results showed that 18 children (72%) have medium to high IQ. Adherence to the diet was observed in the majority of 21 patients (84%). The results of the analysis showed that IQ has a statistically significant relationship with dietary compliance and phenylalanine level (P<0.05).

The PKU screening program in West Azerbaijan province has been effective and we have seen a reduction in the complications of this disease. However, despite the follow-up and implementation of the program, we still see some special complications such as mental retardation, which requires the coherence and continuity of the program in order to minimize the complications caused by this disease.

Background and Although molds are regarded as the main fungal allergen sources, evidence indicates that spores of Basidiomycota including Agaricus bisporus (A. bisporus) can be also found at high concentrations in the environment and may cause as many respiratory allergies as molds. The aim of the present study was to evaluate specific immunoglobulin E (IgE) and immunoglobulin G (IgG) antibodies against A. bisporus via immunoblotting technique in individuals working at mushroom cultivation centers.
In this study, 72 workers involved in the cultivation and harvest of button mushrooms were enrolled. For the analysis of serum IgE and IgG, A. bisporus grown in Sabouraud dextrose broth was harvested and ruptured by liquid nitrogen and glass beads. The obtained sample was centrifuged and the supernatant was collected as “crude extract” (CE). CE was separated via Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE). The separated proteins were transferred to a nitrocellulose filter and the bands responsive to IgE and IgG were identified by anti-human conjugated antibodies. All participants were screened in terms of total IgE level.
Among 72 workers, 18 (25%) had a total IgE level higher than 188 IU/mL. In SDS-PAGE, the CE of A. bisporus showed 23 different protein bands with a molecular weight range of 13-80 kDa. The sera of 23.6% and 55.5% of participants showed positive response, with specific IgE and IgG antibodies against A. bisporus in the blot, respectively. The bands with molecular weights of 62 and 68 kDa were the most reactive protein components of A. bisporus to specific IgE antibodies. Moreover, bands with molecular weights of 57 and 62 kDa showed the highest reactivity to IgG, respectively. Also, 62 and 68 kDa components were the most reactive bands with both specific IgG and IgE antibodies.
The obtained findings revealed that A. bisporus has different allergens and antigens, which contribute to its potential as an aeroallergen in hypersensitivity-related reactions of the lungs.