zahra samadian

The current research was designed to analyze the effect of moderate-intensity exercise training (MEXT), solely and simultaneous with insulin, on the network between oxidative stress and Hsp70 and Hsp90 chaperones after experimental type I diabetes (DM) induction in rats.

In the experimental study, 36 mature Wistar rats were assigned into control and experimental type I DM-induced groups, and then the diabetic animals were categorized to sedentary type I DM-induced (SDM), exercise training-sole without DM (E), exercise training DM-induced (EDM), insulin-treated sedentary DM-induced (ISDM), and exercise training insulin-treated DM-induced (EIDM) groups. After 6 weeks, Johnson’s score was evaluated to analyze the spermatogenesis ratio.

The Hsp70 and Hsp90 expression levels, testicular total antioxidant capacity (TAC), protein peroxidation ratio, testicular DNA fragmentation ratio, and mRNA damage were investigated. The animals in EDM and EIDM groups (solely and simultaneously) represented a significant (P<0.05) improvement in Johnson’s score, spermatogenesis, and TAC ratios versus SDM animals. Moreover, the DM-induced DNA and mRNA damage and protein peroxidation ratio were significantly (P<0.05) recovered in EDM and ISDM groups, which was more remarkable in the EIDM group. The EDM and EIDM groups exhibited significant (P<0.05) increment in Hsp70 and Hsp90 expression levels versus the control and SEDT1 animals. However, the EIDM group exhibited no significant changes compared to the control animals.

The EX could ameliorate the EDT1-induced detrimental impact by up-regulating Hsp70 and Hsp90 expressions. Meanwhile, it exerts potentially more effective impact, when it is considered simultaneously with insulin therapy.

Background and Prevalence of overweight and obesity caused by a sedentary lifestyle and poor diet is the problem of health that one of its side effects is Non-Alcoholic Fatty Liver Disease (NAFLD). The aim of this study was to investigate of tissue and blood indices of liver and metabolic syndrome in patients with nonalcoholic fatty liver during a period of exercise training.
In this randomized controlled trial, 29 overweight and obese women with liver steatosis with an age range of 22 to 52 years, were randomly divided into two groups: aerobic exercise (n = 13) and control (n = 16). Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate). The control group was sedentary during the same period. Blood samples to determine levels of liver enzymes (SGOT, ALK, SGPT) and serum lipid profile (TG, CHO, HDL, LDL) were collected before and after the test. Data were analyzed using SPSS version 21.
The results show significant changes of anthropometric parameters (waist circumference) and biochemical variables (ALK and total cholesterol) between the two-experimental and control groups(p≤0/05).
Due to significant changes in a few indicators of the study, 12 weeks of aerobic exercise seems to be at least appropriate way to manage and control the fatty liver and its complications.

Risk of premature mortality and cardiovascular disease in people with diabetes are twice that of non-diabetics, but the role of inflammatory biomarkers such as resistin and CRP that used for prediction of these disease is unknown after exercise. So, the aim of the present study was to examine the proinflammatory role of resistin and CRP, after aerobic and resistance exercise in patients with type 2 diabetes. 40 women with type 2 diabetes were selected as available and by purposive sampling and were randomly assigned into 2 experimental groups of aerobic training (n = 14), resistance training (n = 13) and control group (n = 13) groups. Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate), the resistance group received (resistance training 3 times a week in 3 sets of 10 repetitions with 40-60% of a repetition maximum). The control group was sedentary during the same period. Blood samples to determine the levels of resistin, CRP, insulin, HbA1c and glucose in pre-and post-tests were collected. Statistical analysis was performed using, Dependent t test, one way Anova, Pearson correlation with spss software (version 21). According to statistical analysis of the results, Resistin and CRP increase and decrease, respectively, in both exercise training groups, anthropometric measurements(weight, BMI, %Body fat and Waist to hip ratio) only decreased in aerobic group, insulin resistance only decreased in resistance group and glycated hemoglobin and glucose decreased in both training groups (p≤0/05). Also there was a significant inverse correlation between resistin and CRP in post-test of resistance group (P≤0/05). Due to changes in resistin and CRP levels after exercise, it dose not seem that resistin causes insulin resistance and be a predictive factor for cardiovascular disease.

Resistin is a new hormone that is secreted from adipocytes which can be associated with obesity and insulin resistance. The effects of exercise trainings on resistin levels and its association with metabolic indices are unknown. The aim of the present study was to determine the response of serum resistin to aerobic exercise and its association with metabolic indices in women with type 2 diabetes Mellitus. In this quasi-experimental study, 40 women with type 2 diabetes were randomly divided into two experimental (n=20) and control (n=20) groups. The experimental group received 12 weeks of aerobic exercise, 3 times a week for 20-50 minutes at 50-70% of maximum heart rate. The control group was sedentary during the same period. Blood samples were collected to examine the biochemical variables in pre-and post-tests. The mean of age and BMI was 59/70±5/28 years and 31/80±3/87 respectively. Aerobic exercise decreased weight, body fat percent, body mass index, lipid profile, fasting glucose and glycosylated hemoglobin while resistin was increased (P≤0/05). Insulin levels and insulin resistance did not change significantly (P≥0/05), also there was a significant inverse correlation between resist in and cholesterol in post-test (P≤0/05). According to the increase in resistin levels and because of no significant change in insulin resistance, it is unlikely that resistin linked obesity to insulin resistance in type 2 diabetes Mellitus.

Resistin، as an adipokine is associated with obesity and insulin resistance، but the effects of different exercise trainings on the levels of this hormone is unknown. The aim of the present study was to compare the effects of aerobic with resistance exercise training on change in serum resistin level in obese postmenopausal women with type 2 diabetes. Subjects and In a quasi-experimental study 40 women with type 2 diabetes were selected as available and by purposive sampling and were randomly assigned into 3 groups of aerobic training (n = 14)، resistance training (n = 13) and control (n = 13) groups. Aerobic group accomplished (12 weeks of aerobic training، 3 times a week، for 20-50 minutes at 50-70% of maximum heart rate)، the resistance group received (resistance training 3 times a week in 3 sets of 10 repetitions with 40-60% of a repetition maximum). The control group was sedentary during the same period. Blood samples were collected for measurement of the levels of resistin، insulin، HbA1c and glucose. Insulin resistance was calculated with HOMA-IR equation. Resistin serum level was increased in both exercise training groups (P<0. 05)، anthropometric measurements decreased in aerobic group only (P<0. 05)، while insulin resistance was decreased in resistance group (P<0. 05). Glycated hemoglobin and glucose decreased in both training groups (P ˂0. 05). It seems that during 12 weeks، both types of aerobic and resistance exercise training have beneficial effects، through different mechanisms، in patients with type 2 diabetes.