جستجوی مقالات مرتبط با کلیدواژه « ترموژنز » در نشریات گروه « تربیت بدنی »

The aim of this study was to evaluate the combined effect of resveratrol and aerobic exercise on the expression of genes involved in thermogenesis and lipid profile in the subcutaneous adipose tissue of C57BL/6 mice.

Thirty-two male mice with a mean weight of 16±4 g were randomly divided into four groups (n=8).  1. Resveratrol (Res), 2. Control, 3. Aerobic exercise (Exe), 4. Resveratrol+Aerobic exercise (Res+Exe). The mice received resveratrol by gavage five times/week for eight weeks. The exercised mice trained on a treadmill for eight weeks, five sessions/week with an average intensity of 65-50% of maximum oxygen consumption (Vo2max). Adipose tissue was extracted after completing the research protocol and 24 hours after the last training session, subcutaneous adipose tissue was extracted and the expression of genes (PGC1a, FNDC5, UCP1, PRDM16, and SIRT1) in adipose tissue was measured using Real-time PCR.

 The results showed that the levels of FNDC5, SIRT1, and UCP1 in the adipose tissue of Res mice were higher than the control group.  Also, the expression of PGC1α, FNDC5, UCP1, PRDM16, and SIRT1 in the adipose tissue of Exe mice was higher than the control group. The markers of thermogenesis and genes involved in adipose tissue browning were significantly in the Res+Exe group higher than the Res and Exe groups.  The levels of HDL in the Res+Exe group were higher than the control group and the levels of LDL, triglyceride and total cholesterol were lower in the Res+Exe group than the control group.

 Aerobic exercise and resveratrol have a significant synergistic effect on increased thermogenesis and increased expression of UCP1, PRDM16, PGC1α, SIRT1, and FNDC5 compared to Exe and Res group alone.  Increased expression of FNDC5 in subcutaneous adipose tissue following modification of aerobic exercise and resveratrol is modulated by SIRT1.