جستجوی مقالات مرتبط با کلیدواژه "کوئرستین" در نشریات گروه "تربیت بدنی"

Nowadays, physical exercise and using the food supplements containing flavonoids are considered as the main drivers of positive regulation of nerve growth factors and improvement of neuromuscular function. Quercetin is one of the plant flavonoids that crosses the blood-brain barrier and plays an effective role in improving brain health. The aim of this research was to investigate the effect of quercetin supplementation on the responses of sirtuin-1 (SIRT-1), brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) to high intensity interval exercise and continuous exercise in female athletes.

This is a semi-experimental, double-blind, applied research with a pre-and post-test design. Forty female athletes from Zabol University with sports experience between one and three years (Mean±SD; age, 21.3±61.0 years; body mass index, 21.79±3.12 kg/m2) were selected and randomly divided into equal groups (n=10) including: 1) high intensity interval exercise + quercetin, 2) continuous exercise + quercetin, 3) high intensity interval exercise + placebo and 4) continuous exercise + placebo. At the beginning and at the end of 14 days, the participants performed a session of continuous exercise (at 60% of VO2max) and an interval exercise (4 intervals of 4 minutes activity at 90% of VO2max followed by 3 minutes recovery) and during these 14 days, the supplement and placebo groups consumed two 500 mg capsules of either quercetin or dextrose daily. Fasting blood sampls were collected at four stages, before and immediately after the first and second acute exercise (prior to and at the end of 14 days of supplementation, respectively) and analysed for measuring SIRT-1, BDNF and IGF-1 by using ELISAtechnique. Statistical analyses of the data were performed using the analysis of variance with repeated measures and Bonferroni post-hoc test.

After high intensity interval and continuous exercises SIRT-1, BDNF, and IGF-1 increased significantly (P<0.001). After 14 days of quercetin consumption, the responses of SIRT-1, BDNF, and IGF-1 to acute high intensity interval and continuous exercises increased significantly (P<0.01). However, no significant differences were observed between the responses of SIRT-1 (P=0.14), BDNF (P=0.32) and IGF-1 (P=0.16) to high intensity interval and continuous exercises.

It seems that short-term quercetin supplementation increases the baseline levels and responses of SIRT-1, BDNF and IGF-1 indices to high intensity interval and continuous exercises in female athletes, and probably stimulate nerve growth and improve neuromuscular function, though, two types of high-intensity interval and continuous exercises did not make a difference in the response of these variables, which requires further study in this field.

The aim of this study was to evaluate the importance of aerobic exercise and quercetin supplementation on the progression of colon cancer in rats and changes in the effects of IGF1 and myostatin on muscle tissue and the shape of fluctuations in atrophy and muscle wasting.

The subjects of this study included 25 male Wistar rats (weight: 250± 30 g, age: 12 weeks) which were homogenized by weight and randomly divided into 5 groups (5 heads in each group) of healthy controls. Cancer control group, cancer group + quercetin supplement, cancer group + aerobic exercise, cancer group + quercetin supplement + aerobic exercise was evaluated. Measurements of IGF1 and myostatin in muscle tissue of rats were performed according to the standard and ELISA method. SPSS software was used for data analysis.

The results showed that 8 weeks of aerobic training in muscle tissue of mice with colon cancer had a significant effect on the mean values of myostatin (p = 0.005) and IGF1 (p = 0.019). 8 weeks of quercetin supplementation in muscle tissue of mice with colon cancer had a significant effect on mean myostatin and mean values IGF (P <0.05) in the control and experimental groups (8 weeks of quercetin supplementation) had no significant effect on mean myostatin and IGF1. (P>0/05)

In general, the findings showed that aerobic exercise and quercetin supplementation improve IGF1 and reduce myostatin in muscle tissue of mice with colon cancer.

Colon cancer or colorectal cancer is the growth of cancerous masses in the colon. According to research evidence, the use of antioxidants and regular exercise are the best ways to prevent and treat many diseases. This study aimed to investigate the effect of eight weeks of intermittent exercise and Quercetin consumption on the brain-derived neurogenic factor (BDNF) and cyclic-adenosine monophosphate responsive element-binding protein (CREB) in the brain hippocampus of rats with colon cancer which has many influences on cognitive functions.

The subjects of this study included 50 male Wistar rats (weight: 250±30 grams, age: 12 weeks) which were homogenized by weight and were randomly divided into five Healthy Control, Cancer Control, Cancer + Quercetin supplement, Cancer + Intermittent exercise, Cancer + Quercetin supplement + Intermittent exercise groups (10 rats in each group). BDNF and CREB measurements were performed in the rats’ hippocampus according to the ELISA standards and method. SPSS software was used for data analysis.

The results showed that eight weeks of intermittent exercises had a significant effect on the mean score of BDNF (p = 0.047) and CREB (p = 0.032) in rats’ hippocampus with colon cancer. Eight weeks of Quercetin supplementation had no significant effect on the mean BDNF score (p = 0.792) and the mean CREB score (p = 0.363) in rats’ hippocampus with colon cancer

In general, the findings showed that intermittent exercise and Quercetin supplementation improve BDNF and CREB in the hippocampus of rats with colon cancer.