جستجوی مقالات مرتبط با کلیدواژه "il-10" در نشریات گروه "تربیت بدنی"

Obesity is a condition known to disrupt the homeostasis of inflammatory markers. Therefore, the purpose of the present study was to investigate the effect of 8 weeks of combined endurance-resistance training with garlic supplement on the serum levels of hs-CRP, IL-6 and IL-10 in inactive overweight boys.

This study was conducted on 46 healthy inactive volunteer male (mean age: 19.51±1.88 years, weight: 77.05±7.07 kg, height: (164.25 ± 6.53 cm) were randomly divided into 4 groups: training-placebo, supplement, training- supplement and placebo. The groups daily consumed 250 mg of garlic. The training groups also performed three sessions per week for 8 weeks. Serum levels of hs-CRP, IL-6 and IL-10 were measured using ELISA kits. Data were analyzed using correlated t-test and ANCOVA. The significant level was set at P<0.05.

In the examination of the post-test between the groups, there was a significant difference between interleukin 10 levels (P=0.002, F=5.92), but no significant difference was found in the concentrations of interleukin-6 and hs-CRP (P=0/15, F=1.86; P=0.27, F=1.22). The results of Tukey's post hoc test showed that interleukin 10 levels were significantly different in the training -placebo groups with placebo (P=0.023) and supplement with placebo (P=0.003). In examining the post-test levels between the 3 groups, no significant difference was found in any of the investigated variables (P= 0.078, F=2.72; P= 0.15, F=1.86; P=0.27, F=1.22) (IL-10, IL-6 and hs-CRP variables, respectively).

The improvement of hs-CRP, IL-6 and IL-10 by performing combined training alone or with the consumption of garlic probably indicates the necessity of performing trainings in interventions to improve selected inflammatory indicators.

Increased anti-inflammatory cytokines and decreased inflammatory cytokines through exercise is one of the ways to reduce chronic inflammation. Current study aimed at investigating the effect of endurance training on inflammatory markers in male smokers. Two groups: experimental (mean age 25.30 ± 2.95 years, n=10) and control (mean age 26.11 ± 2.76 years, n=10) were selected randomly. Endurance training protocol including of 20 minutes of running with intensity of 55-65% of heart rate reserve was performed by the experimental group during six weeks. 48 hours after the last training session, measurements similar to those before training and blood samples were collected. The data were analyzed by dependent t test within a group and independent t test between the groups (α≤0.05). The results showed that six weeks of endurance training intervention significantly decreased CRP (P=0.012) and significantly increased IL-10 (P=0.01) in the experimental group. The results indicated the effect of exercise on inflammatory markers in male smokers. On the other hand, these findings show that smokers may reduce the side effects of smoking if they have endurance training. But this requires further research on the role of endurance training and its relationship to inflammation.

Background & Although the inflammatory process activation is necessary in the first period after myocardial infarction (MI), but it's over continuing can facilitate the recurrence of MI. Due to the positive effects of aerobic exercise training programs on inflammation, it seems that endurance exercise training (EET) have a positive effect on inflammatory condition in patients with MI. Accordingly, the aim of the present study was to investigate the effect of endurance exercise training on TNF-α and IL-10 genes expression following experimental MI in male rats.
18 rats were randomly divided to 3 groups: Sham, control and EET. MI was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days. EET intervention was initiated 2 days after MI and continued for 4 weeks. After extracting RNA from cardiac tissue and synthesizing cDNA, expression levels of TNF-α and IL-10 genes were relatively quantified using Real time-PCR. Data were analyzed by using one-way analyses of variance (ANOVA) at P
The TNF-α gene expression in the EET group were significantly lower than the control (P=0.002) and sham (P=0.001) groups. The IL-10 gene expression in the EET group was significantly lower than the control group (P=0.023), and the expression of this gene in the control group was significantly higher than the sham group (P=0.011).
It seems that EET may accelerate the process of improving the inflammatory status, through modulating the expression of TNF-α and IL-10 genes, after MI.

The aim of this study was to investigate and compare the effect of different modes of exercise training on IL-6 and IL-10 and weight control in adult male rats. In this experimental-trail, 40 Wistar rats were divided into five groups: (1) Sedentary (Sed), (2) Endurance Training (ET), (3) High-Intensity Interval Training (HIIT), Sprint Training (ST), Incline Treadmill Workout (ITW); Sed group was regarded as control. ET group received 8-wk Mild-intensity endurance exercise. The exercise schedule of HIIT group consisted of high intensity interval training for 8 weeks (with Active recovery). ST group run on treadmill for 8-weeks with high intensity. ITW group ran on the inclined treadmill. IL-6 and IL-10 was assessed using commercial ELISA kits and the data were analyzed by one-way ANOVA. Statistical differences were considered significant at p