The effect of 8 weeks of combined endurance-resistance training with garlic supplement on the serum levels of hs-CRP, IL-6 and IL-10 in inactive overweight boys

Obesity is a condition known to disrupt the homeostasis of inflammatory markers. Therefore, the purpose of the present study was to investigate the effect of 8 weeks of combined endurance-resistance training with garlic supplement on the serum levels of hs-CRP, IL-6 and IL-10 in inactive overweight boys.

This study was conducted on 46 healthy inactive volunteer male (mean age: 19.51±1.88 years, weight: 77.05±7.07 kg, height: (164.25 ± 6.53 cm) were randomly divided into 4 groups: training-placebo, supplement, training- supplement and placebo. The groups daily consumed 250 mg of garlic. The training groups also performed three sessions per week for 8 weeks. Serum levels of hs-CRP, IL-6 and IL-10 were measured using ELISA kits. Data were analyzed using correlated t-test and ANCOVA. The significant level was set at P<0.05.

In the examination of the post-test between the groups, there was a significant difference between interleukin 10 levels (P=0.002, F=5.92), but no significant difference was found in the concentrations of interleukin-6 and hs-CRP (P=0/15, F=1.86; P=0.27, F=1.22). The results of Tukey's post hoc test showed that interleukin 10 levels were significantly different in the training -placebo groups with placebo (P=0.023) and supplement with placebo (P=0.003). In examining the post-test levels between the 3 groups, no significant difference was found in any of the investigated variables (P= 0.078, F=2.72; P= 0.15, F=1.86; P=0.27, F=1.22) (IL-10, IL-6 and hs-CRP variables, respectively).

The improvement of hs-CRP, IL-6 and IL-10 by performing combined training alone or with the consumption of garlic probably indicates the necessity of performing trainings in interventions to improve selected inflammatory indicators.