جستجوی مقالات مرتبط با کلیدواژه « il-18 » در نشریات گروه « تربیت بدنی »
تکرار جستجوی کلیدواژه «il-18» در نشریات گروه «علوم انسانی»-
Background
Fatty liver disease is the most important reason for chronic liver diseases such as liver fibrosis, cirrhosis and liver cancer. The aim of this study was the effect of endurance training and probiotic consumption on IL-18 gene expression in male rats with steatosis.
Materials and MethodsIn this experimental study, 32 rats (average weight 200-250 grams) were randomly divided into four groups (healthy control, modeled (steatosis) group, steatosis + probiotic group, and steatosis + probiotic + exercise group). Training groups for 8 weeks, 5 sessions every week, in the beginning week with a speed of 18 meters per minute, time of 10 minutes, and every week the speed of 1-2 meters per minute and the time was increased by 10 minutes, so that In the fourth week, the speed reached 22 meters per minute and the time reached 40 minutes. The groups receiving the supplement received 109 CFU/ml of Lactobacillus rhamnus GG by gavage daily for 8 weeks and 5 days a week. IL-18 gene expression in liver tissue was measured by Real-time PCR method. The data were evaluated using the statistical method of one-way analysis of variance and significance level (P ≥ 0.05).
ResultsThe results showed that endurance training along with probiotic consumption significantly decreased IL-18 gene expression in rats with steatosis.
ConclusionIt seems that performing endurance training along with probiotic consumption can have a greater effect than the effect of probiotic alone on IL-18 gene expression.
Keywords: Steatosis, Probiotic, IL-18, Endurance Training} -
مقدمه و هدفاز نشانه های رایج دوران سالمندی افزایش 2 تا 4 برابری سطوح سایتوکاین های پیش التهابی است. هدف از این مطالعه بررسی اثر یک دوره تمرینات TRX بر شاخص های قلبی و عروقی PTX3، CRP و IL-18 در مردان سالمند دارای اضافه وزن بود.مواد و روش هادر این پژوهش نیمه تجربی، 30 مرد سالمند دارای اضافه وزن شرکت کرده و به طور تصادفی به دو گروه تمرین TRX (15 نفر) و کنترل (15 نفر) تقسیم شدند. گروه تجربی به مدت 12 هفته و هر هفته 3 جلسه به مدت 60 دقیقه (10 دقیقه گرم کردن، 40 دقیقه تمرین و 10 دقیقه سرد کردن) تمرینات را انجام دادند. نمونه های خونی در دو مرحله پیش آزمون و 48 ساعت پس از آخرین جلسه تمرین، جهت سنجش سطوح سرمی PTX3، CRP و IL-18 تحلیل شدند.یافته هاتمرینات TRX، موجب کاهش معنی دار در سطح سرمی PTX3، CRP و IL-18 گردید (0.05>P).بحث و نتیجه گیریبه نظر می رسد این نوع تمرینات بتواند در کاهش مارکرهای التهابی CRP و IL-18 در افراد سالمند موثر واقع شود. این تمرینات به عنوان یک عامل موثر در بهبود عوامل خطر قلبی - عروقی مرتبط با افزایش سن پیشنهاد می شود.کلید واژگان: PTX3, تمرینات TRX, CRP, IL-18, سالمندان}Introduction andPurposeOne of the common signs of old age is a 2-4 times increase in the levels of pro-inflammatory cytokines. The aim of this study was to investigate the effect of a course of TRX exercises on cardiovascular parameters PTX3, CRP, IL-18 in overweight elderly men.Materials and methodsIn this semi-experimental study, 30 overweight elderly men participated and were randomly divided into two TRX training groups (15 people) and control (15 people). The experimental group performed exercises for 12 weeks and 3 sessions each week for 60 minutes (10 minutes of warm-up, 40 minutes of training and 10 minutes of cooling down). Blood samples were collected in two pre-test stages and 48 hours after the last training session to measure the serum levels of PTX3, CRP and IL-18. The data were analyzed using covariance and paired t test at a significant level of P≤0.05.ResultsTRX exercises caused a significant decrease in serum levels of PTX3, CRP, IL-18 in the post-test of the experimental group (P≤0.05).Discussion andConclusionIt seems that this type of exercise can reduce inflammatory markers CRP and IL-18 in elderly people. These exercises are suggested as an effective factor in improving cardiovascular risk factors related to aging.Keywords: PTX3, TRX exercises, CRP, IL-18, Elderly}
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Introduction
lL-17 and IL-18 are pro-inflammatory cytokines. The aim of present study is to evaluate the effect of endurance training on IL-17 and IL-18 in heart tissue of rats which have been poisoned by cadmium.
Material & MethodsTwenty Wistar rats were randomly divided into four groups: 1) control, 2) sham, 3) cadmium and 4) high intensity interval training (HIIT training) with cadmium. HIIT training was performed 8 weeks and 3 days a week (80 to 110% of their VO2max). Cadmium groups received 2mg/kg cadmium intraperitoneally everyday. At the end of protocol, the rats were sacrificed and their heart tissues were prepared to measure gene expression of IL-17 and IL-18. The data was analyzed by independent sample t-test and one-way ANOVA (P≥ 0.05).
ResultsThe HIIT training led to significantly reducing IL-17 and IL-18 gene expression in heart issue of rats (P= 0.001).
ConclusionThe 8 weeks of HIIT training will improve the levels of pro-inflammatory cytokines in rats which have been poisoned by cadmium.
Keywords: Cadmium, HIIT training, IL-17, IL-18}
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