جستجوی مقالات مرتبط با کلیدواژه « thiosemicarbazide » در نشریات گروه « علوم پایه »
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Research involved preparing new compounds from hydroxyquioline with formaldehyde to form P1 and then reacted with benzylalcohol to form P2 reacted chloroaceticacid and SOCl2 to form P3 and P4 with thiosemicarbazide to form P5 and P2 reacted with benzydehyde to form chalcone reacted with H2O2 to form P8. The compounds were identified via TLC, FTIR 1HNMR and 13CNMR. The measured the antibacterial and antioxidant activity of the prepared compounds, to give high resulte.Keywords: hydroxyquioline, benzylalcohol, Formaldehyde, Thiosemicarbazide, benzydehyde antioxidant, Biological activity}
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در این پژوهش دو ترکیب باز شیف با نام های 1- (2-هیدروکسی بنزیلیدین)-4- فنیل تیوسمی کاربازید (2-HTSC) و 1- (3-هیدروکسی بنزیلیدین)-4- فنیل تیوسمی کاربازید (3-HTSC) سنتز و اثر بازدارندگی آن ها روی خوردگی فولادکربنی در محیط هیدروکلریک اسید 15% بررسی شد. در این راستا اثر بازدارندگی این دو ترکیب به وسیلهی روشهای کاهش وزن، روشهای الکتروشیمیایی نظیر اسپکتروسکوپی امپدانس الکتروشیمیایی (EIS) و پلاریزاسیون، آنالیز میکروسکوپ الکترونی روبشی (SEM)، طیفسنجی پراش اشعه X (EDX) و ایزوترم جذب مورد بررسی قرار گرفت. غلظتهای 5/0، 1، 5/1 و 2 میلی مولار از بازدارنده بررسی شدند که بهترین نتیجه در غلظت 5/1 میلیمولار بهدست آمد. نتایج نشان داد که باز شیف 3-HTSC درصد بازدارندگی بهتری نسبت به باز شیف 2-HTSC دارد. نتایج حاصل از پلاریزاسیون نشان می دهد که بازدارنده های مورد استفاده به عنوان بازدانده مختلط عمل کرده و پتانسیل خوردگی را به طور چشمگیری جابه جا نمی کند. جذب بازارنده ها روی سطح فولاد از هم دمای جذب لانگمویر پیروی می کند و نتایج حاصل از پارامترهای ترمودینامیکی نشان از جذب فیزیکی-شیمیایی دارد. در حضور بازدارنده میزان جذب سطحی یونهای مهاجم کلراید بر بستر فلز به ترتیب برای بازدارنده 2-HTSC و 3-HTSC به ترتیب 26% و 74% کاهش یافت که ناشی از غالب بودن برهمکنشهای بهتر 3-HTSC با بستر فلز در مقایسه با بازدارنده 2-HTSC است.
کلید واژگان: بازدارنده خوردگی, شیف باز, سمی کاربازید, فولادکربنی, هیدروکلریکاسید}In this work, two Schiff bases named 1-(2-hydroxybenzylidene)-4-phenylthiosemicarbazide (2-HTSC) and 1-(3-hydroxybenzylidene)-4-phenylthiosemicarbazide (3-HTSC) were synthesized and evaluated their inhibitory properties on corrosion of carbon steel in 15% HCl environment. Inhibitory effect of compounds were investigated by weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS), polarization, Scanning electron microscopy (SEM) analysis, X-ray diffraction (EDX) spectroscopy and absorption isotherms. Concentrations of 0.5, 1, 1.5 and 2 mM of the inhibitor were evaluated and the best result was obtained at a concentration of 1.5 mM. The results showed that the 3-HTSC Schiff base has a better inhibitory percentage than the Schiff base 2-HTSC. Adsorption of inhibitors on the steel surface follows all Langmuir adsorption isotherm and the results of thermodynamic parameters indicate physico-chemical adsorption. In the presence of inhibitor, the adsorption rate of chloride ions on the metal substrate decreased by 26% and 74% for inhibitors 2-HTSC and 3-HTSC, respectively, due to the predominance of better interactions of 3-HTSC with the metal substrate in Comparison with 2-HTSC inhibitor.
Keywords: corrosion inhibitor, Schiff base, Thiosemicarbazide, Carbon steel, Hydrochloric acid} -
کنژوگه کردن نانوذرات فلزی با تیوسمی کاربازید یا مشتقات آن می توند منجر به بهبود پایداری و قابلیت ضدسرطانی آنان از طریق القاء آپوپتوزیس در سلول های سرطانی شود. بنابراین، هدف از این مطالعه سنتز نانوذرات اکسید روی عامل دار شده با گلوتامیک اسید کنژوگه شده با تیو سمی کاربازید (Zn@Glu/TSC) و سپس ارزیابی قابلیت ضد سرطانی آنان از طریق سنجش سمیت سلولی و بیان ژن های دخیل در تنظیم آپوپتوزیس در سلول های آدنوکارسینومای معده (AGS) است. ویژگی های فیزیکی-شیمیایی نانوذرات سنتز شده از طریق آنالیزهای FT-IR، میکروسکوپ الکترونی نگاره و گذاره و اندازه گیری پتانسیل زتا تعیین گردید. میزان سمیت سلولی و دوز مهاری میانه نانوذرات بر سلول های AGS از طریق آزمایش MTT تعیین گردید. سپس میزان بیان ژن های caspase-3، bax و bcl-2 در سلول های مواجهه یافته با نانوذرات از طریق آزمایش Real time PCR مورد ارزیابی قرا گرفت. نتایج نشان داد که نانوذرات ساخته شده کروی بوده و دارای اندازه 10 تا 90 نانومتر بودند. ماهیت ذرات توسط طیف سنجی FT-IR تایید شد و مقدار پتانسیل زتا نیز mV 7/11- به دست آمد. نانوذرات ساخته شده در غلظت های µg/mL 62/15 و بالاتر به طور چشمگیری باعث کاهش زنده مانی سلول های AGS شدند و مقدار دوز مهاری میانه µg/mL 90 به دست آمد. همچنین، در سلول های مواجهه یافته با نانوذرات بیان ژن های caspase-3 و bax به میزان 67/1 و 80/1 برابر افزایش داشت درحالی که میزان بیان ژن bcl-2 به میزان 70/0 برابر در مقایسه با سلول های کنترل کاهش معنی دار داشت.
کلید واژگان: سرطان معده, تیوسمی کاربازید, نانوذرات اکسید روی, ضد سرطان}Conjugation of metal nanoparticles (NPs) to thiosemicarbazide improves their stability and anticancer potential. This work was aimed at preparing ZnO NPs functionalized with glutamic acid conjugated to thiosemicarbazide (Zn@Glu/TSC). Then, the anticancer potential of nanoparticles was studied by evaluating their cytotoxicity and the expression of the genes involved in cell apoptosis in AGS cancer cells. Physicochemical properties of the NPs were characterized using FT-IR, SEM, and TEM imaging, and Zeta potential assays. Cytotoxicity and inhibitory concentration 50% value of the NPs was determined using the MTT assay. Moreover, the expression of the caspase-3, bax, and bcl-2 genes among NPs treated AGS cells was investigated using Real-time PCR assay. According to the results, the NPs were spherical with a size range of 10-90 nm. FT-IR assay confirmed the proper synthesis of the NPs and the zeta potential was determined -11.7 mV. The synthesized NPs showed significant cytotoxicity at concentrations ≥ 15.62 µg/mL and 50% inhibitory concentration was determined 90µg/mL. Besides, the expression of caspase-3 and bax genes in NPs treated cells increased by 1.67 and 1.80 folds, respectively, while the bcl-2 gene was regulated by 0.70 folds, compared to the control cells.
Keywords: anticancer, gastric cancer, Thiosemicarbazide, Zinc Oxide Nanoparticles} -
In this work new thiosemicarbazide derivatives were synthesized to obtain the intermediate of thiosemcarbazone compounds (1-5) by thiosemicarbazide reaction with several aromatic aldehydes, following treatment of compounds (1-5) with 2-chloroethanoic acid with sodium acetate, a series of compounds (6-8) was prepared. There were 1,3-oxazepine-4,7-dione derivatives compounds (9,10) with phthalic anhydride. By heating thiosemicarbazide with carbon disulfide and anhydrous sodium carbonate in absolute ethanol, 5-amino-1,3,4-thiadiazole-5-thiol compound (11) was prepared. The azomethines synthesized by reaction of compound (11) with aromatic aldehyde compounds (12-14), then processed to obtain mercaptoacetic acid as compounds (15-17). The compound (18) was made with ethylchloroacetate from the cyclization thiosemcarbazone compound (2) in the presence of fused sodium acetate. The reaction of compound (11) with chloroacetylchloride produced compound (19) then treated with urea to obtained compound (20) followed by 4- phenyl phenacyl bromide to prepare compound (21). The characterization outcomes for the prepared compounds verified their chemical structures using IR spectroscopy, NMR, and melting points.
Keywords: Thiosemicarbazide, Heterocyclic compounds, Thiosemicarbazone, thioxoimidazolidin-4-one ring, [1, 3] oxazepin -4(3H)-yl)thiourea} -
According to the advantages of electrochemical analysis like high selectivity, high sensitivity, low analyte concentration, cost-effective, portable and easy-to-use setup, this method has attracted a great amount of attention among scientists for determination of different compounds. in this work, a simple, inexpensive, and rapid electrochemical method for the determination of thiosemicarbazide (TSC) was developed by using the modified glassy carbon electrode with multi-walled carbon nanotubes (MWCNT/GCE). Cyclic voltammetry (CV) studies indicated that TSC had a sensitive irreversible oxidative peak at 0.7 V. Compared to the untreated electrode, the modified electrode showed a negative shift in the oxidation peak of TSC. Differential pulse voltammetry on MWCNT/GCE showed a linear dependence on the concentration of TSC in the range of 1 × 10-6-100 × 10-6 M with a limit of detection (LOD) of 0.6 × 10-6 M. The proposed method was successfully applied to the determination of TSC in city water samples.Keywords: Thiosemicarbazide, Electrochemical Determination, Glassy Carbon Electrode, Multi-walled carbon}
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Room temperature dielectric and antibacterial behavior of thiosemicarbazide capped low dimension Silver and Gold nanoparticles were studied. The effect of size on the properties, by capping silver (Ag) and gold (Au) nanoparticles by thiosemicarbazide (TSC) was investigated. The nanoparticles were synthesized by chemical reduction method. The structural formation, surface morphology, phase stability and crystalline nature were characterized by UV-Vis spectroscopy, Fourier transform Infra Red (FT-IR) spectroscopy, Differential Scanning Calorimeter (DSC), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Powder X-ray Diffraction (PXRD). Room temperature dielectric and Impedance spectroscopy were performed to understand the electrical transport behavior and the results indicated that TSC capped Ag nanoparticles have demonstrated better electrical properties. Also, antibacterial studies were performed on human pathogenic bacteria by agar well diffusion method which attested TSC capped Ag nanoparticles have better antibacterial properties.Keywords: Anti bacterial, Capping, Dielectric, Impedance spectroscopy, Silver, Gold nanoparticles, Thiosemicarbazide}
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A series of transition metal complexes with two thiosemicarbazide Schiff bases, 1-(4-dimethylaminobenzyl- idene)thiosemicarbazide (ABTSC) and 1-(2-pyridincarboxyl-idene) thiosemicarbazide (TCTS) were synthesized with Co(II), Ni(II), Zn(II), Cd(II) and Ag(I) salts (chloride and acetate). These complexes were characterized by different methods including proton nuclear magnetic resonance (1HNMR), Fourier transform infrared (FT-IR), ultra violet visible (UV-Vis), molar conductance (λm), atomic absorption spectroscopy (AAS) and elemental analysis (CHNS). All complexes were applied as a catalyst for oxidation of aromatic alcohols. The effects of reaction time, temperature, catalyst amount, oxidant and solvents were investigated in detail. The oxidation of alcohols occurs effectively and selectively with H2O2 as the oxidant. For instance, 4-Methoxybenzyl alcohol is oxidized to the corresponding aldehyde with 95% conversion and 100 % benzaldehyde selectivity under the optimum conditions.Keywords: Alcohol oxidation, Thiosemicarbazide, Schiff base metal(II)complex}
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In the present work, an adsorptive stripping voltammetric method using a hanging mercury drop electrode (HMDE) was described in order to determine the ultra trace of thiosemicarbazide in different real samples. The method is based on accumulation of thiosemicarbazide on mercury electrode. The potential was scanned to the negative direction and the differential pulse stripping voltammograms were recorded. The instrumental and chemical parameters were optimized. The optimized conditions were obtained in pH of 10.0, accumulation potential of 0.00 mV, accumulation time of 60 s, scan rate of 80 mV s-1 and pulse height of 50 mV. The relationship between the peak current versus concentration was linear over the range of 0.50-100.00 ng mL-1. The limits of detection were 0.03 ng mL-1 and the relative standard deviation at 5.00 and 50.00 ng mL-1 of thiosemicarbazide ion were obtained 2.1 and 1.7%, respectively (n = 8).Keywords: Thiosemicarbazide, Adsorptive stripping voltammetry, Determination, Real sample}
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