جستجوی مقالات مرتبط با کلیدواژه « bioactive compound » در نشریات گروه « زیست شناسی »

Consideration of marine organisms as potential sources of bioactive compounds and drug agents has increased in recent years. Skin is considered to be the largest and fastest growing organ in the human body and it plays the most important role in protecting of diseases and environmental factors. Due to the large surface area of the skin, it is sensitive to various diseases, including acne, dermatitis, and so on. Therefore, the present study was performed to evaluate the effect of brown algae phlorotannin extract and emulsion containing the extract against 6 pathogenic bacteria. Phlorotannin content was measured using phluoroglucinol reagent. Then, the antibacterial activity of the extract and its emulsion against 6 bacterial strains including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Propionibacterium acnes and Staphylococcus epidermidis were evaluated. The phlorotannin content was 13.94±0.29. The results showed MIC and MBC levels were lower in S. aureus, P. aeruginosa and P. acnes than in E. coli, B. subtilis and S. epidermidis, indicating the better performance of phlorotannin extract against them. Also, the emulsion containing the extract had a diameter of inhibition zone against P. acnes, E. coli, P. aeruginosa, B. subtilis. The results show that the formulation containing phlorotannin extract has potentials in the treatment of bacterial skin infections.

Halophile and halotolerant microorganisms produce bio-active molecules under environmental stresses. The microorganisms play a role in bio-remediation of heavy metals including nickel; the most important water pollutant in urbans. Here studying of nickel resistant microorganisms from salt lake of Haj Ali Gholi Khan for their potential in bio-active molecules producing based on PKS genes variations is aimed. Chemical analyses using atomic absorption method for soil and water of the lake were done. The microorganisms isolated from MGM, MH and SWN culture media with 23, 10 and 2 % salt. The isolates were screened for nickel resistant’s followed by analyzing for presence of PKS genes using gene specific internal primers. Fifty, 22 and 21 microorganisms were isolated from SWN, MH and MGM medium respectively. 65% of the isolates were nickel resistant those carry the potential to synthesize bio-active compounds. These organisms because of their abilities in bio- remediation and also synthesizing bio molecules can be used in biotechnology.

Marine actinobacteria are virtually unlimited sources of novel secondary metabolites and are very important from therapeutic and industrial points of view. There are more than 22,000 known microbial secondary metabolites, 70% of which are produced by actinobacteria. Actinobacteria from terrestrial sources have been examined and identified since the 1950s, for many significant antibiotics, anticancer, anti-tumor and immunosuppressive activities. However, obtaining the previously discovered metabolites from terrestrial actinobacteria habitats attracted studies to different ecological habitats. The ecological role of actinobacteria in the marine environment is greatly neglected.  Currently, the existence of marine actinobacteria have received considerable attention due to the structural diversity, unique biological activities of their secondary metabolites and a growing need for the development of new and potent therapeutic agents. In recent years, newly discovered secondary metabolites have shown a range of biological activities such as antibacterial, antifungal, anticancer, antitumor, cytotoxic, anti-inflammatory, anti-parasitic, anti malaria, antiviral, antioxidant, etc. In this review, an evaluation is made on the current status of research on marine actinobacteria yielding pharmaceutically active secondary metabolites. Bioactive compounds from marine actinobacteria possess distinct chemical structures that may form the basis for synthesis of new drugs that could be used to combat resistant pathogens. With the increasing advancement in science and technology, there would be a greater demand for new bioactive compounds synthesized by actinobacteria from various marine sources in future.