جستجوی مقالات مرتبط با کلیدواژه "carbidopa" در نشریات گروه "شیمی"

In this study entacapone, levodopa, and carbidopa, were determined with high precision in the presence of each other. UV-VIS spectroscopy was used as an easy and low-cost technique for the analysis and the derivative spectrophotometric method was applied for elimination of absorption interferences. For this purpose, the derivative spectra of each compound were studied separately, and zero crossing points were determined for each of them. The zero-crossing points in which the absorption was observed only for one compound were found and evaluated for quantitative analysis. Calibration curves were drawn from the second and third derivative signals for each compound and the linear range was determined. The method was linear in the range of 1-5 µg/mL for levodopa, 0.25-1.7 µg/mL for carbidopa, and 2-14 µg/mL for entacapone. The accuracy and precision of the proposed method were evaluated by within-day and between-day tests (CV < 1.56% and error < 1.7%) and finally, these drugs were determined in pharmaceutical dosage forms by the developed method.

Electrochemical behaviors of carbidopa at the surface of the graphite screen printed electrode (SPE) modified with Cu(II) nanocomplex, [CuCl2(salophen)]. H2O (salophen=o-phenylenediaminebis(salicylidenaminato)) were studied. The oxidation peak potential of the carbidopa at a surface of Cu/SPE appeared at 360 mV that was about 100 mV lower than the oxidation peak potential at the surface of the traditional SPE under similar condition. On other hand, the oxidation peak current was increased for about two times at the surface of Cu/SPE compared to SPE. The linear response range and detection limit were found to be 0.5-700 μM and 0.1 μM, respectively. The proposed sensor was successfully applied for the determination of carbidopa in real samples.

This paper reports the selective determination of carbidopa (CD) in the presence of uric acid (UA) using 2,7-bis(ferrocenyl ethyl)fluoren-9-one modified carbon nanotube paste electrode (2,7-BFCNPE) in 0.1 M phosphate buffer solution (PBS) pH 7.0. In PBS of pH 7.0, the oxidation current increased linearly with two concentration intervals of CD, one is 0.2 to 22.0 μM and, the other is 22.0 to 750.0 μM. The detection limit (3σ) obtained by DPV was 68.0 nM. The practical application of the modified electrode was demonstrated by determining CD in urine samples.