جستجوی مقالات مرتبط با کلیدواژه « nanocarriers » در نشریات گروه « شیمی »

Today, the use of biological materials, both in the form of drug supplements and in the form of enriched foods, has been considered. These substances have shown various properties such as anti-inflammatory, anticancer, antidiabetic, immune system booster, and antimicrobial. Although these compounds originate from natural sources, they have little stability against environmental conditions. Encapsulation is an effective method that can increase the chemical and biological stability of biological compounds and also protect them from inevitable reactions. Compared with microcapsules, nanocapsules have a higher surface-to-volume ratio and are of great interest for in vivo and ex vivo biological applications. Polymeric nanocapsules can be prepared from natural or synthetic polymers. Encapsulated bioactive compounds should be released at the right time and place. Several release mechanisms have been proposed for trapped bioactive compounds, including simple diffusion, swelling, and decomposition with diffusion. Release under the influence of environmental conditions such as solvent, temperature, pressure, molecular interactions, changes in pore size, and network disintegration.

The utilization of nanoparticles as drug carriers is of utmost importance due to their ability to effectively transport drugs to specific areas of the body at the appropriate time. Incorporating anticancer agents into nanoparticle-based drug delivery systems has emerged as a highly efficient approach for targeting cancer cells. These systems possess the capability to penetrate cells more effectively, enabling the precise combination of drugs within the cells. Moreover, they take advantage of the enhanced permeability and retention (EPR) effect, allowing for better accumulation of drugs at tumor sites. Particle size is a critical factor influencing the efficacy of anticancer nanocarriers. The zeta potential range of -30 to +30 millivolts is particularly favorable for designing nanocarriers, as it ensures their stability in the bloodstream and prolonged circulation. Many studies have indicated that the optimal particle size for targeted drug release falls below 300 or 200 nanometers. This size range facilitates efficient drug diffusion among tissues and enhances permeability. This study, for the first time, focuses on analyzing particle size obtained through dynamic light scattering and evaluating the surface charge potential to enhance the release of anticancer drugs.

The global rise in cancer cases highlights the need for effective therapeutic strategies that not only reduce side effects but also enhance performance and efficacy. Conventional treatments such as medical methods, radiation therapy, and chemotherapy have limitations and safety concerns. To address these issues, drug delivery systems (DDSs) or nano drug delivery systems( NDDSs) have been proposed to release drugs specifically on cancer cells while sparing normal tissue. pH-responsive systems have been developed to improve the selectivity of anticancer drugs by taking advantage of the lower pH of tumor sites. This approach minimizes side effects and overdosage and is made possible by enhanced permeability and retention (EPR), which increases drug accumulation at tumor sites. Particle size is a crucial factor in nanocarriers containing anticancer drugs, and in this study, for the first time, the particle size of nanocarriers (nano systems)was analyzed using electron microscopy to improve the release of anticancer drugs.