جستجوی مقالات مرتبط با کلیدواژه « Acetaminophen » در نشریات گروه « شیمی »

In this study, tranexamic acid (Txa) (in 0.1 M Sulfuric acid) modified glassy carbon electrode (GC) was tested, for the first time, as a sensor for determining the most consumed pain reliever, paracetamol (ACOP) by differential pulse voltammetry (DPV). The tranexamic acid-modified glassy carbon (rTxa/GC) electrode was characterized by a scanning electron microscope (SEM). Cyclic voltammetry (CV), linear sweep voltammetry (LSV), and electrochemical impedance spectroscopy (EIS) (in aqueous and nonaqueous solution) were used to evaluate the electrochemical performance of electrodes. The modified electrode increased the oxidation peak current of ACOP significantly in this case. The experimental results provide that rTxa/GC electrode displayed excellent electrocatalytic response to the oxidation ACOP. Additionally, the rTxa/GC electrode exhibited excellent electrocatalytic activity for the electrochemical determination of ACOP in Britton-Robinson (BR) buffer solution with pH values ranging from 2 to 12. As a result, the effective electroactive surface area of rTxa/GC electrode increased by using a BR buffer solution with pH 6. The linear range was 25 – 80 μM for ACOP with a limit of detection (LOD) of 4.7 μM and a limit of detection (LOQ) of 14.2 μM.

In this work, an easy method was employed to successfully develop La3+-doped ZnO nanoflowers and Guar-Gum (GG) modified screen printed electrode (La3+/ZnO/GG/SPE), and La3+/ZnO/GG/SPE was applied for the electrochemical detection of Ascorbic Acid (AA). The electrochemical methods, such as Cyclic Voltammetry (CV), chronoamperometry (CHA), and Differential Pulse Voltammetry (DPV) were used to evaluate the electrochemical performances toward ascorbic acid on the La3+/ZnO/GG/SPE. Good linear-ship was observed for ascorbic acid in the ranges of 1.0–700.0 μM, with the detection limits of 0.03 μM. Moreover, this sensor proved favorable to simultaneously determine ascorbic acid and acetaminophen. Finally, the modified electrode has fairly good performance during the employment of real sample analysis to determine the content of ascorbic acid. These results indicate that the La3+-doped ZnO nanoflowers are supposed to be a promising material in the electrochemical determination of ascorbic acid and acetaminophen in real samples.

In this study, we used a prepared from chitosan-capped AuNPs for the determination of trace amount acetaminophen drug in various matrices such human fluids by kinetic spectrophotometric method. The calibration curve was linear in the range of (0.05 to 10.0 µg L−1). The standard deviation of (1.9%), and detection limit of the method (0.05 µg L−1 in time 6 min, 325 nm) were obtained for Sensor level response chitosan-capped AuNPs with (95%) confidence evaluated. Observed outcomes confirmed the suitability recovery, and a very low detection limit for measuring the acetaminophen drug. The method introduced to measure acetaminophen drug in real samples such as urine, and blood can be used for other drugs, and hospital samples.

In this investigation, a fluidized bed photocatalytic reaction system was designed to eliminate emerging contaminants: acetaminophen and pyridine in water. Titanium dioxide (TiO2) doped with aluminum (Al3+) using the photo-deposition technique was used as a catalyst and supported on alumina beads (Al2O3). The catalyst´s doping was carried out by photo deposition with aluminum particles. The reactor, which is a quartz vessel with a capacity of 500 mL, where aluminum pearl, was previously impregnated with titanium oxide and calcined at 550 °C. The reactor feeding was carried out using a pump at a flow of 0.5 L/min; two lamps of UV light with 365 nm were used. The synthesized catalyst was characterized through Energy-dispersive X-ray analysis (EDX), Transmission Electron Microscopy (TEM), and X-ray diffraction (XRD) techniques, showing adequate impregnation of aluminum in the formed compound. Photoactivity analysis of the catalyst was performed at different contaminant concentrations, from 5-40 ppm for acetaminophen and 5-60 ppm for pyridine. Mineralization of more than 85% acetaminophen and 70 % pyridine was achieved after 300 min of UV illumination. The results demonstrate that using this photocatalytic arrangement as a decontamination technique for the pollutants such as acetaminophen and pyridine is feasible.

For the first time, an analytical methodology based ondifferential pulse voltammetry (DPV) at a glassy carbon electrode (GCE) assisted by two multivariate calibration (MVC) models including back propagation-artificial neural network (BP-ANN), non-linear class, and partial least squares-1 (PLS-1), classical class, thatthey have been constructed on the basis of non-bilinear first order differential pulse voltammetry (DPV) data,was developed and validated for the simultaneous determination of Ascorbic acid, Uric acid, Acetaminophen, and Noradrenalinto identify which approach offers the best predictions.The baselines of the DPV signals were corrected by asymmetric least square spline regression (AsLSSR) algorithm. Before applying the PLS-1,lack of bi-linearity was tackled by potential shift correction using correlation optimised warping (COW) algorithm. The multivariate calibration (MVC) model was developed as a quaternary calibration modelin a blank human serum sample (drug-free) provided by a healthy volunteer to regard the presence of a strong matrix effect which may be caused by the possible interferents present in the serum, and it was validated and tested with two independent sets of analytes mixtures in the blank and actual human serum samples, respectively.According to the obtained results, the PLS-1 was recommended for simultaneous determination of AA, UA, AC, and NA in both blank and actual human serum samples .

In this study, a new Zeolite Al/Na (ZAN) was synthesized and characterized and then a new modified Carbon Paste Electrode with ZAN was made to determine Acetaminophen. Electrochemical studies using Linear Sweep Voltammetry and differential pulse voltammetry were used to determine electrochemical  Acetaminophen . In the presence of Acetaminophen , modified electrode with ZAN shows a specific anodic peak at ~ 0.59 volts which is the result of using electrocatalytic oxidation of  Acetaminophen . The determination limit of this method to measure  Acetaminophen was 5.8 µM, the relative standard deviation for 7 repeated measurements was 1.1 % and linear range of the calibration to measure  Acetaminophen was 10 up to 115 µM . for the characterization of ZAN nanostructures we used SEM (Scanning Electron Microscopy), DLS (Dynamic Light Scattering) and FT-IR (Fourier-Transform Infrared spectroscopy).

Acetaminophen is a widely used drug worldwide and is frequently detected in water and wastewater as a high-priority trace pollutant. This study investigated the applicability of the adsorption processes using a composite of magnetic chitosan and multi-walled carbon nanotubes (MCS@MWCNTs) as an adsorbent in the treatment of acetaminophen. The model was well fitted to the actual data, and the correlation coefficients of R2 were 0.9270 and 0.8885, respectively. The maximum ACT removal efficiency of 98.1% was achieved at ACT concentration of 45 mg L-1, pH of 6.5, MCS@MWCNTs dosage of 400 mg L-1, and the reaction time of 23 min. The result shows that BET specific surface area of 640 m2 g-1. The adsorption isotherms were well fitted with the Langmuir Model (R2 =0.9961), depicting the formation of monolayer adsorbate onto the surface of MCS@MWCNTs. The maximum monolayer adsorption capacity of 256.4 mg g-1 was observed for MCS@MWCNTs. The pseudo-second-order kinetic model well depicted the kinetics of ACT adsorption on MCS@MWCNTs (R2=0.9972). Desorption studies showed that the desorption process is favored at high pH under Alkaline conditions. The results demonstrate that the MCS@MWCNTs is an efficient, durable, and sustainable adsorbent in water purification treatment.

In the present work, a carbon paste electrode modified with tris (acetylacetonato) iron complex (Fe(acac)3) nanoparticles was used to fabricate a novel electrochemical sensor for the electrochemical determination of acetaminophen (AC). The synthesized Fe(acac)3 nanoparticles was characterized by Fourier transform infrared (FTIR) spectroscopy and the surface morphology and elemental composition of the fabricated electrode were analyzed by  field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy (EDS). Cyclic voltammetry and differential pulse voltammetry methods were used for evaluating the electrochemical behavior of the modified electrode. To optimize the measurement conditions, the effect of various parameters such as pH, deposition time, scan rate, potential, time, and interferences were successfully monitored. The modified electrode enhanced the peak currents relative to the bare carbon paste electrode. Moreover, the proposed electrochemical sensor showed good agreement with previously reported methods and was effectively employed for the quantification of acetaminophen in blood serum.

This study aimed at preparing a Carbon Ionic Liquid Electrode (CILE) modified with a new composite of Multi-Walled Carbon Nano-Tubes (MWCNTs) and TiO2 nanoparticles for AC determination. The proposed electrode was made of a Carbon Paste Electrode (CPE) modified with TiO2 Nano-Particle (NP)-decorated MWCNTs and a binder of IL 1-hexyl-pyridinium hexafluorophosphate (HPFP) (MWCNT/TiO2/CILE). The nanocomposite structure characterization was done via X-ray Energy-Dispersive Spectroscopy (EDS) and Field-Emission Scanning Electron Microscopy (FESEM). The electrochemical behavior of Ac was investigated via the Cyclic Voltammetry (CV) technique at the MWCNT/TiO2/CILE. The MWCNT/TiO2/CILE was applied for Ac determination by Square-Wave Voltammetry (SWV) technique in real samples. The excellent electrocatalytic activity of the proposed nanocomposite leading to Ac electrochemical oxidation in phosphate buffer solution (pH 6.0) was evidenced. The results of Square-Wave Voltammetry (SWV) revealed a wide linear range of 0.01-30 µM and the detection limits of 0.003 µM for the modified electrode under optimal conditions. This electrode was successfully employed to detect Ac concentrations in plasma and tablet samples with good repeatability and reproducibility

In this work, a cobalt Schiff base complex (CoSB) immobilized at the surface of Fe3O4@SiO2‐NH2 nanoparticles was synthesized and characterized using different characterization techniques such as Scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD). The prepared nanocomposite (Fe3O4@SiO2-NH2/CoSB) was applied as a sensitive modifier in carbon paste electrode (CPE) for simultaneous determination of acetaminophen (AC) and chlorpheniramine (CP). The Fe3O4@SiO2-NH2/CoSB/CPE exhibited good electrochemical response towards the detection of AC and CP. In addition, an excellent separation between the voltammetric signals for these analytes at the surface of modified electrode was observed.  The suggested methodwas effectively employed for concentration variation studies of a mixture containing these drugs. The dynamic linear ranges of 5.0 × 10−7 to1.0 × 10−3 M and 8.0 × 10−6 to 1.0 × 10−3 M with detection limits 4.0 × 10-7 M and 5.0 × 10-6 M (for S/N = 3) were achieved for AC and CP, respectively. The performance of the presented electrochemical nanosensor was assessed by quantifying the two drugs in spiked human blood serum and in tablets.

In this study, the application of a partial least squares algorithm (PLS) was proposed for simultaneous spectrophotometric determination of acetaminophen, celecoxib, diazepam, and famotidine in hair, wastewater, and urban water samples. Although the determination of these drugs is very important in biological and pharmaceutical samples, spectrophotometric measurements were reported at the same time due to the spectral overlap. The results of applying PLS showed that acetaminophen, celecoxib, diazepam, and famotidine could be simultaneously determined within the concentration ranges of 4-20 ppm, 4-20ppm, 2-10 ppm, and 4-20 ppm respectively in calibration set, prediction set, and real samples. The proposed method does not require spectral correction and chemical pretreatment for quantitative analysis of the mentioned drugs.

In this study, AuPdCu-rGO-MWCNTs nanocomposite was synthesised by a chemical reduction method which was applied to fabricate an electrochemical sensor for simultaneous determination Dopamine (DA), Acetaminophen (AC) and Tryptophan (Trp) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The formation of Au, Pd, and Cu nanoparticles on rGO-MWCNTs nanocomposite are characterized by XRD, FTIR, and SEM techniques. The relationship between the concentration of DA, AC, and Trp with the response of AuPdCu-rGO-MWCNTs/CPE was linear in the range of 10 nM to 8.3 μM, 20 nM to 12.5 μM and 10 nM to 9.4 μM by DPV technique, and 0.007-8.0, 0.011-11.6 and 0.008-8.8 μM by amperometric method, respectively. Also, the detection limits for DA, AC, and Trp were calculated to be 3, 7 and 4 nM, respectively by the voltammetric method and 2, 5 and 3 nM for DA, AC and Trp, by amperometric method. The investigations show that AuPdCu-rGO-MWCNTs/CPE has acceptable selectivity, stability, repeatability, and reproducibility. Finally, AuPdCu-rGO-MWCNTs/CPE was successfully applied to determine the analytes in the urine, blood plasma, and AC Tablet by desirable percentage of relative standard deviation and recovery.

Acetaminophen overdose is one of severe global health challenges. In this study, adsorption technique was used to reduce acetaminophen overdose. Carbo tablets derived by wet granulation technique, coded as formulated carbo tablet (FCT) and alginated formulated carbo tablets (FCT-Alg), were characterized using the pharmaceutical drug procedures (hardness, disintegration time, tablet strength, friability) and instrumental techniques including, FTIR, SEM, and DSC analysis. DSC thermogram revealed that, the excipients were compatible with the active pharmaceutical ingredient (API). Batch adsorption experiments were carried out in the simulated gastric fluid (SGF) to monitor the role of some parametric factors (pH, concentration, carbo dosages, and PCM dosages). The tablet displayed favorable hardness and disintegration time (3.40 min). Optimum adsorption was observed at pH 1.2 for FCT in SGF (RE of 92.80%); FCT-Alg in SGF (RE of 99.17%). The results depicted that, the adsorption of the acetaminophen in SGF gave up to 99.65% removal efficiency, and compared with the commercial carbo tablet (CCT) with adsorption efficiency of 96.44%.

A modified carbon paste electrode with Fe3O4 nanoparticles/multi-walled carbon nanotubes nanocomposite (Fe3O4/MWCNTs/CPE) was developed as an efficient sensor for simultaneous determination of acetaminophen (AC) and theophylline (TP). The Fe3O4/MWCNTs nanocomposite was characterized by scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). Also, electron transfer rate of [Fe(CN)6]3-/4- as a redox couple probe on the surface of the Fe3O4/MWCNTs/CPE was studied using electrochemical impedance spectroscopy (EIS). The modified electrode preserved and combined the properties of the individual modifiers synergistically. The anodic peak currents of AC and TP were increased at the nanocomposite modified electrode compared to the bare electrode. Under the optimal experimental pH, the linear analytical curves were obtained in the range of 2-1000 µM with a limit of detection (LOD) (S/N=3.0) of 1.68 µM for AC and in the range of 3-1000 µM and with a detection limit of 2.48 µM for TP using the differential pulse voltammetry (DPV) results. The applicability of the proposed method was successfully proved for simultaneous determination of these compounds in drug samples.

Paracetamol is one of the most commonly used analgesics and its overdose causes toxicity. Therefore investigation of simple and effective techniques to determine paracetamol in the metabolism is very important. In this study TiO2 modified Fluorine-doped Tin Oxide (FTO) electrodes were investigated for photoelectrochemical determination of paracetamol and parameters affecting the photoelectrochemical signal of the electrodes were investigated. Initially, FTO electrodes were modified by adsorbing two commercial TiO2 (Merck and Degussa P25) and used for paracetamol determination. Higher photocurrent value was obtained by Degussa P25 (DegTiO2) modified electrode with respect to Merck one, therefore the optimization of the other analytical parameters was carried out with DegTiO2 modified electrodes. The effect of DegTiO2 amount on the FTO, solution pH, and applied voltage on the photocurrent values for paracetamol oxidation was studied. The electrode prepared as four-layer of DegTiO2 on the FTO surface showed the highest photocurrent value at 0.30 V and at pH 5.0. The photocurrent values are linear from 0.25 μM to 10 μM concentration of paracetamol and the limit of detection of paracetamol concentration is 0.07 μM. These results show that DegTiO2 modified FTO could be used as an effective and sensitive photoelectrochemical paracetamol sensor

YbVO4 nanoparticles were prepared using sodium tetraphenylborate (Na(B(C6H5)) as a novel capping agent. The effect of the capping agent on the morphology and size of the product particles was studied. The characterization of the particles was performed using X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magneto-metery (VSM). The synthesized of YbVO4 NPs nanoparticle was used to investigate the electrochemical behavior of acetaminophen in an aqueous medium using the linear sweep voltammetric (LSV) technique.

A novel chemically modified electrode was constructed based on multi-walled carbon nanotubes, MCM48 molecular sieve composite modified glassy carbon electrode .The modified electrode showed that it can be used for simultaneous determination of acetaminophen (ACT) and codeine (COD), simultaneously. The measurements were carried out by the application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. The fabricated sensor revealed some advantages such as excellent selectivity, good stability and high sensitivity toward ACT and COD determination. Application of DPV method under the optimum conditions showed the modified electrode provides linear responses versus ACT concentrations in the range of 0.2-40 µM and 80-350 µM. The results for COD showed the linear responses in the ranges of 4-70 µM and 150-400 µM respectively using DPV method. The modified electrode was used for determination of ACT and COD in real samples like human blood serum and plasma with satisfactory results.

In this study, the La3+/Co3O4 nanoflowers were synthesized by co-precipitation method. The morphology of the La3+/Co3O4NFs were characterized using scanning electron microscopy (SEM), and were further used to modify the graphite screen printed electrode (GSPE). The electrochemical behavior of acetaminophen at La3+/Co3O4NFs/GSPE has been studied in aqueous solutions. Experimental results showed that the La3+/Co3O4NFs modified GSPE possess excellent electrocatalytic activity toward the detection of acetaminophen. Under optimum conditions, the La3+/Co3O4NFs modified electrode exhibited high sensitivity and stability to acetaminophen over a wide linear range of concentrations from 0.5μM to 250.0μM, with a detection limit of 0.09μM. Finally, the proposed sensor was successfully applied to the detection of acetaminophen in real samples.