جستجوی مقالات مرتبط با کلیدواژه "controlled release" در نشریات گروه "مواد و متالورژی"

The metal-organic frameworks (MOFs) due to their large specific surface area and high biocompatibility are suitable as carriers for drug delivery systems (DDSs). In the present study, doxorubicin (DOX) as an anticancer drug was loaded into the UiO-66-NH2 MOFs to decrease the adverse side effects of pristine DOX use and to increase its efficiency through the controlled release of DOX from MOFs. The MOFs were synthesized via microwave heating method and characterized using X-ray diffraction, scanning electron microscopy, and Brunauer-Emmett- Teller analysis. The drug loading efficiency, drug release profiles from synthesized MOFs and pharmacokinetic studies were investigated. The biocompatibility of drug-loaded-UiO-66-NH2 MOFs was also evaluated by their incubation in L929 normal fibroblast cells. The average particle sizes of UiO-66-NH2 MOFs and DOX loaded-MOFs were found to be 175 nm, and 200 nm respectively. The Brunauer-Emmett- Teller surface area of UiO-66-NH2 MOFs and DOX (100 μg mL-1) loaded-UiO-66-NH2 MOFs were estimated to be 1052 m2g-1, and 121 m2g-1, respectively. The synthesized MOFs exhibited high capability for the controlled release of DOX from MOFs as a pH sensitive carrier. The DOX release data were best described using Korsmeyer-Peppas pharmacokinetic model (R2≥0.985). The cell viability of synthesized MOFs against fibroblast normal cells was found to be higher than 90%. It could be concluded that the UiO-66-NH2 MOFs could be used as an effective pH sensitive carrier for loading anticancer drugs.

The present study includes an overview of the applications of clay-based nanocomposites from the past decade to date in various fields such as pharmaceuticals, water treatment, food packaging, electricity, automotive, and especially the production of chemical fertilizers with water retention and slow release. In the agricultural area, one of the promising materials that help green chemical engineering and green chemistry is slow-release fertilizer (SRF). Clay minerals and clay nanocomposites provide cost-effective and efficient material for this purpose. In this paper, the research and development of polymer nanocomposites based on clay in recent years with the focus on their application as novel fertilizers have been reviewed. Clay minerals are promising reinforcements to manufacture high-performance, lightweight, and low-cost nanocomposites because of their abundance, layered structure, low cost, and rich intercalation chemistry.

The potential utilization of encapsulation techniques in food, pharmaceutical and agricultural products preparation, presents a new alternative for complementary technologies such as targeting delivery vehicles and carriers for active food ingredients. Encapsulation could be accomplished by different techniques like: simple or complex coacervation, emulsification technique, phase separation, spray drying, spray chilling or spray cooling, extrusion coating, freeze drying, fluidized-bed coating, liposomal entrapment, centrifugal suspension separation, co-crystallization and molecular inclusion complexation. Encapsulation is a method by which one bioactive material or mixture of materials is coated by the other material. It is designed for protection, isolation, assists in the storage and controlled release. A timely and targeted release improves the effectiveness of ingredients, broadens the application and ensures optimal dosage, thereby improving cost-effectiveness process for manufacturers. This review highlights recent innovations in encapsulation and controlled release technologies. In addition, design principle of novel peppermint oil delivery systems which displays the new structured biomaterials for capsules fabrication by complex coacervation technique, besides microemulsification method for bioactive material, Lactobacillus encapsulation and targeted release studies reported.