جستجوی مقالات مرتبط با کلیدواژه "اسید لینولئیک کونژوگه" در نشریات گروه "پزشکی"

Due to the importance of controlling recurrence of colorectal cancer, the effect of serum lipid profile and the fatty acid composition of cancer cell membranes on the response to treatment and survival, and the lack of clinical study on the effect of conjugated linoleic acid supplementation (CLA) in these patients, this study investigated the effect of CLA supplementation on serum fatty acid pattern, lipid profiles, and carcinoembryonic antigen (CEA) tumor marker in patients with rectal cancer treated with preoperative chemotherapy.

In this randomized double-blind placebo-controlled pilot study, 31 patients with rectal cancer undergoing chemoradiotherapy assigned into the CLA group (n = 15), receiving 3 g CLA/d, and placebo group (n = 16) receiving placebo capsules for 6 weeks. Before and after intervention, serum fatty acid pattern, triglyceride, cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and CEA were evaluated.

In placebo group, CLA supplementation increased the percentage of serum CLA (P = 0.35). CLA supplementation increased alpha linolenic acid (P = 0.01) significantly, and decreased the total omega-6 fatty acids and the omega-6 to omega-3 ratio. As compare with placebo, CLA supplementation had no significant effect on lipid profiles (P > 0.05).

Considering the positive effects of CLA on omega-3 fatty acids, and to our knowledge, this is the first study that assess the effect of CLA supplementation; further studies with larger sample size are needed to generalize findings of this study.

Colorectal cancer (CRC) is one of the most common types of cancer affecting 1.23million individuals per and is the third most common cancer in males and the second in Females. In addition¡ it is the third most common cause of cancer-related death.In recent years Oxidative stress and Chronic inflammation are believed to be two of the risk factors of colorectal carcinogenesis that have an important role in colorectal cancer(CRC). Biological and epidemiological studies indicated that some factores such as diet an life style can prevent incidence of CRC.Conjugated linoleic acid (CLA) is one of the functional lipids and is known to have physiological benefits such as the prevention and attenuation of lifestyle-related Colorectal cancer.
PubMed¡ Google scholar¡ ISI webofknowledge and Scopus were searched for studies published between 2000 till 2015. “inflammatory”¡ “anti oxidant”¡ “Rat”¡ “Conjugated linoleic acid” in combination with “Colorectal”¡ “Cancer” were used as search terms. Clinical trials with high quality and review articles were collected.
it is suggested reduction of inflammatory factors level as a key point in controlling cancer is a novel approach to prevent malignancy. For this purpose dietary CLA is suggested as a powerful factor to decrease inflammatory factors and increase anti oxidant factors level.

Although the effect of Conjugated Linoleic Acids (CLAs) on blood pressure and body composition is revealed in several in vitro and animal studies، the results of human studies are controversial. The purpose of the current clinical double blind trial was to determine the effect of 2 months CLA supplementation on blood pressure and body composition of non trained healthy young male students. This randomized، double-blind، placebo-controlled clinical trial was conducted on 66 non trained healthy male students. Before and after eight weeks supplementation with 4´0. 8g. d-1 CLA or placebo (soybean oil)، lean body mass and fat mass were measured with BIA، trunk and visceral fat and waist circumference were measured with ViScan. Physical activity amount and dietary intake of participants were similar together، because they lived in dorms. Statistical analyses were performed using the SPSS16 software، the statistical tests being analysis of covariance، Independent sample t test، paired-sample t-test and Mann-Whitney U tests. CLA supplementation had no effect on blood pressure، lean body mass، body fat mass، trunk and visceral fat and waist circumference. These results show that CLA does not affect on body composition and blood pressure in non trained young male students.