جستجوی مقالات مرتبط با کلیدواژه « التیام » در نشریات گروه « پزشکی »

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. The present study was conducted to determine the effect of somatic antigens of nematode Marshallagia marshalli on healing of full-thickness skin wound healing in mice.

In this study, 72 adult mice were divided into 4 groups A, B, C and D. Subgroups A the dose of 40 μg /mice, B the dose of 20 µg / mice, C the alum adjuvant group and D were considered as negative controls. Twenty four hours after made wounds, all mice were treated subcutaneously at the four sides of the wound. The wounds evaluated at days 0,1.3,6,9,12,15,18 and 21 by taken digital photographs. The images were analyzed by Image J software.

After analyzing a significant difference were showed in the percentage of wound contraction, wound healing and the infiltration rate of inflammatory cells in the treatment group with a dose of 20 μg (P ≤ 0.05).

The results of this study indicate that application of somatic antigens of Marshallia marshalla nematode with a dose of 20 μg subcutaneous injection accelerates the healing process of wound healing.

The purpose of this study is to investigate the histopathology and immunohistochemistry of the effect of 5% Plantago labceolata. extract on open wound healing in rat skin.

After extracting the plant extract using the mixed method, 40 healthy male rats with an average weight of 200-250 grams were selected and randomly divided into two main groups of 20. Group 1 is the treatment group and group 2 the control group each of the main groups being divided into 4 subgroups (days 3, 7, 14,21) were divided. For the histopathological and immunohistochemical investigation of the healing process, the wounds of the mice of the subgroups in both the main groups were removed in full thickness and with a diameter of 15 mm and examined for histological studies. After sectioning, with the qualitative staining method of hematoxylin eosin and Masson's trichrome,using antibodies against transforming growth factor beta and vascular endothelial growth factor of the study groups, and the obtained information was converted into quantitative information. and was subjected to statistical analysis.

Finding this study has shown that about 95% of women had felt at least one problem in their hands. During COVID-19 pandemic, hand washing with disinfectants were repeated more and more, furthers skin of the hands will be two times more damaged as compared to normal conditions, so the need to increase hand health training as part of general health, especially in older adults' women in advance.

The results show that it is possible to use the polar extract of Plantago Lanceolata L. plant 5% for wound healing.

Wound healing is an important concern that humankind is facing and attempting to find compounds that have the least side effects on wound healing is important. Since violet flower extract has anti-inflammatory and disinfection effects, in this study the impact of this plant on wound healing was examined.

32 rats were provided from the laboratory animal breeding center in Shahrekord, and after anesthetizing them, a full-thickness skin wound was created by a 2 by 2 Cm stencil in the posterior cervical region. The control group received no treatment, one group received Eucerin, another group received Silver Sulfadiazine 1% and the experimental group received ointment of violet flower extract 20% twice a day. Throughout the study, the length and width of the wounds were measured in each group every three days. On the 3rd, 7th, 14th and 21st days after creating the wound, the rats were anesthetized and the healed tissues were examined for histopathologic studies.

The results showed a significant reduction in wound area in treated animals, especially violets, compared with the control group (P<0.05). Histopathologically, the thickness of the epithelium and the amount of collagen showed a significant increase in the experimental group of violets.

This can probably be attributed to the anti-inflammatory effects of the effective components of violet flower. also it’s likely that these components stimulate collagen production and quicker contraction of wounds. Therefore, the compounds of this plant can be used to treat wounds.

post-operative surgical wound healing is highly important, so, it could be of great benefit to find suitable alternatives for chemical drugs through herbal remedies in Persian Medicine. The purpose of this study was to determine the effect of Arnebia euchroma ointment on surgical wound healing process.

In this experimental study, 24 Wistar rats were randomly divided into four groups (n=6 per group); controls (no intervention), positive controls (silver sulfadiazine cream 1%), intervention group I (Arnebia euchroma ointment), and intervention group II (mixed Arnebia euchroma and silver sulfadiazin cream1%). In all groups, an ulcer was developed in the back of the neck, then the groups were treated for 21 days. Wound healing was evaluated at days 4, 7, 14, and 21. Data were analyzed in SPSS V22 applying one-way ANOVA and Games- Howell post hoc test for normal distribution and Kruskal-Wallis test for non-normal distribution.

Surgical wound healing was found be significantly different between intervention group I and control group at days 4 (P= 0.00) and 7 (P= 0.02). Percentage of wound healing at day 14, in control group, the positive controls, and intervention groups I and II were 81.16±4.4, 84±19.27, 94.28±4 and 82.20±19, respectively. The rate was considerably higher in intervention group I (P= 0.07).

Topical use of Arnebia euchroma root ointment can facilitate surgical wound healing.

Zeolite has skin wound healing capacity. However, its efficacy on burn wound healing has not yet been examined. In this study, we investigated the effects of Zeolite-Agﱧꕪ� nanocomposite on the process of third-degree burn wound healing in mice model.
Ag+ zeolite/gelatin nanocomposite was fabricated by sol-gel method; MTT assay and antimicrobial activity evaluation of the nanocomposite were performed. Third degree burn wound were created on 40 Balb/c mice (n=10) wound per group and treatment administered daily starting on the day of wounding. Treatment groups included untreated control, SSD, gelatin and nanocomposite. Daily photographs were taken and change in wound area relative to initial area was calculated. At 7 and 14 days, animals euthanized and skin samples were taken to histopathologicl evaluation (H&E staining). Then, the study groups were evaluated for wound contraction percent and histopathological parameters.
According to the results of the present study, nano composite-treated wounds revealed significant wound contraction on days 14 compared to control and gelatin treated groups (P In conclusion, based on the results of the present study, it could be concluded that zeolite-Ag/gelatin nanocomposite offered potential advantages in burn wound healing acceleration and improvement. However, clinical use of this nanocomposite needs more supportive studies.

Background and Chronic non-healing diabetic wounds are a major medical challenge worldwide. Stem cell therapy has been developed as a new approach in the management of such wounds that need to be explored further. In the present study we aimed to evaluate the effects of adipose derived mesenchymal stem cells (ADSCs) on gene expression level of some important inflammatory factors involved in wound healing in diabetic animal model.
ADSCs were isolated from adipose tissue of mice and their stemness was identified in terms of specific cell surface markers (CD44, CD90, and CD34) and multi-lineage differentiation potentials. Then 106 stem cells were injected in dermis area around the wounds and the wound tissues were tested for the expression level of IL-8 and IL-10 genes and histopathological analysis at 3rd, 7th, 14th, and 21st days after treatment.
Expression level of IL-10 gene at days 3, 14 and 21 increased significantly (P The present study indicated that stem cells could improve the indicators of wound healing.

Burning provides irreparable effects on the affected patient. Several studies show that these cells may contribute to tissue regeneration whether through producing a variety of bioactive growth factors and/or by differentiation into mesoderm lineage. Several studies demonstrate that stimulated mesenchymal stem cells have more therapeutic potential than unstimulated cell in accelerate tissue wound healing. The aim of the present study was to investigate the effect of subcutaneous administration of stimulated bone marrow-derived mesenchymal stem cells with lipopolysaccharide in repairing or regeneration of skin wounds induced by third-degree burn and to compare it with unstimulated Mesenchymal stem cell in mouse model.
The third-degree skin burn was induced on male mice (N=27). After 1 hour, based on the equal physical condition mice were randomly divided into three separate groups which included control, mesenchyme and LPS groups and then respectively subcutaneously administered with phosphate buffered saline (PBS; 400 µl), mesenchymal stem cells and stimulated mesenchymal stem cells with LPS (106 cell in 400µl PBS) at the burn site. In order to check the speed of the process of 21-days wound repair, tissue section at days 7, 14, and 21 after induction of burn were prepared and stained with hematoxylin/eosin and Masson’s trichrome.
Considering investigated parameters including formation of granulation tissue, angiogenesis, fibroblast proliferation, collagen deposition and the rate and quality of healing of third-degree thermal burns were significantly accelerated in mesenchyme and LPS groups when compared to the control group (P The results demonstrate that stimulate cells whit LPS improve BMScʼs therapeutic effect in some factors of burn wound healing.

Colostrum is the only natural source of transforming growth factors (TGF-α and β) and insulin-like growth factors (IGF-1 and 2) which play a role in wound healing. The aim of the present study was to investigate the effects of bovine colostrum on secondary wound healing in a guinea pig model. Lyophilized bovine colostrum powder, in the form of an ointment (10 % w/w dried powder in semisolid paraffin ointment base), was evaluated for wound-healing potential in an excision wound in guinea pigs. The guinea pigs were divided into two groups of treatment (colostrums ointment) and control (ointment base), each group consisting of six guinea pigs. All animals were anaesthetized and a full-thickness excision wound (square area of 400 mm2) was created in the dorsum skin of all guinea pigs. Wound contraction and total wound healing rates were evaluated. Colostrum ointment found to possess wound healing activity which was evidenced by an increase in the rates of wound contraction and total wound healing when compared with the control group, although differences were not statistically significant. Results of this study indicated that bovine colostrum could improve quality of wound healing but more studies will need to be done to clarify whole bovine colostrum role in burn and infectious wounds.

Scrophularia striata extract has been traditionally used for wound healing. The aim of this study was to evaluate the effect of Scrophularia striata extract on wound healing on mice. In this experimental study، a number of 35 male mice (NMRI) weighing 25-30 g were divided into 5 equal groups. Two 6 mm circular wounds were punched on the back of the mice; moreover they were treated for 3 weeks in separate cages. The first group wasconsidered as the control group and the other groups were treated with phenytoin ointment 1%، alcoholic extract، hydroalcoholic and aqueous 10% twice a day for 21 days respectively. The wounds were daily photographed by a digital camera and the wound area was calculated using Image J software. Data were analysed by Kruskal-Wallis and Mann-Whitney test. The average healing duration in the control group، phenytoin and extracts، aqueous and alcoholic were 9. 1 ± 3 6، 6. 6± 1. 9، 6. 5 ± 1. 7، 6. 7 ± 1. 8 and 6. 1 ± 0. 9 days respectively. The remaining scar size in these groups were 9. 08 ± 1. 83، 5. 84 ± 1. 20، 3. 7 ± 0. 62، 3. 5 ± 0. 74 and 2. 81 ± 0. 79 millimeters respectively. The average duration of scar healing and the remaining treatment groups were significantly different from controls (p<0. 05). Scrophularia striata extract decreased the period of wound healing in mice. Among the three types of extracts، the hydroalcoholic extract demonstrated the best result.

Episiotomy is common perineal trauma in primiparous vaginal birth. Complications after episiotomy include inflammation, edema, dehiscence and perineal pain. Calendula has wound healing effects but there is little information about its application on episiotomy. Thus we aimed to study the effect of Calendula ointment on wound healing of episiotomy. the purpose of this study was to elevate the effectiveness of Calendula ointment on wound healing of episiotomy among primiparous women admitted in Lolagar hospital of Tehran, 2010. the study was carried out using a randomized control trial method; the population included primiparous who had the inclusion criteria of the study. The setting of the study Conducted on 74 primiparous women referred to Lolagar hospital in Tehran which were selected with random allocation method. The case group consisted of 37 women that consumed Calendula ointment and control group consisted of 37 women that consumed hospital’s routine care (Povidon Iodine). The data collection instruments were questionnaire and REEDA Scale (redness, Edema, Ecchmosis, Discharge and Approximation). Questionnaire was demographic, postpartum and neonatal items of primiparous mothers. Perineal wound healing was evaluated using REEDA Scale within 4 hours and 5 days after intervention. Data were analyzed by spss 16 softe ware and presented with chi-square and t-test. Our findings showed that The REEDA score was significantly lower in the experimental group (Calendula ointment) 5 days after episiotomy (p=0.001). Considering the result of this study, it seems that Calendula ointment can be used in episiotomy wound care instead of Povidon Iodine solution because this compound has anti- inflammatory and antimicrobial properties that were more effective than Povidon Iodine in wound pain relief. This method suggested as a safe and effective method with minimal side effects.

It has been shown that antioxidants may contribute to the healing of wounds caused by burns. This study was designed to determine the effects of the ethanolic extract of Cydonia oblonga seeds on second degree burn wounds. In a preclinical study، 48 mice were divided into 4 groups of 12. Group-I (sham) received no treatment، Group- II (negative control) was treated with Vaseline، Groups-III was treated with 1% Cydonia oblonga seed ointment and Group IV (positive control) received silver sulphadiazine twice per day. In the treatment groups، 1 gr ointment twice per day until complete wound healing was used. Animals were assessed by measuring the percent of wound healing، the remained gap of incision injury and total time required for complete healing. The data were statistically analyzed with SPSS software using one-way ANOVA and Tukey’s tests. The results showed that concentration of 1% of Cydonia oblonga seed extract had significantly better burn wound healing effects (99. 502 %) in treatment group in comparison with the control group (92. 97%). This is because the percentage of burn healing was higher and the length of healing was shorter in Cydonia oblonga seed group compared to the control groups (P<0. 05). The results showed that the Cydonia oblonga seed ointment might be beneficial in patients with second degree burn wounds. Further studies are recommended to establish the optimal dose of the extract.

Surgical treatment of some renal neoplasia is partial nephrectomy; but in some cases subsequent injuries lead to complete nephrectomy. Cryogenic surgery as a minimally invasive procedure can be helpful in avoiding complete nephrectomy. The aim of the study is determination of the effect of cryosurgery on macroscopic and microscopic injury and healing of kidney tissue, along with determination of the speed and quality of healing compared with other current procedures. Cryogenic Partial nephrectomy was performed on posterior pole of left kidney of 6 male Dutch rabbit using contacting probe. After 1, 6 and 24 hours, and after 3, 7 and 14 days nephrectomy was done via laparatomy. After recording macroscopic properties of kidneys, they were processed for histopathologic studies. The freezed area in 1 to 24 hours’ samples showed filling of renal tubes by RBCs, hemorrhage in glumerols, fibrinous deposition in capillaries and some interlobular venuls and arteries, along with initiation of cell necrosis. On 3,7,14 day samples, injured and non injured areas were separated by a transitional zone. Gradually, necrotic tissues were reabsorbed which resulted in involution of injured area that makes kidney smaller in size. ‍ It seems that cryosurgery is effective in healing. Cryogenic partial nephrectomy can be done easily and causes only limited injury during operation. This study showed that contacting probe has less invasive effect than needle probes and its healing process is faster and works through reabsorbtion of necrotic tissue.

According to the large number of surgical removal of impacted third molar and prevalence of pain and side effects and importance of prevention to reduce these side effects, the present study was held to evaluate the influence of modified triangular flap and buccal envelope flap on incidence of dry socket and postoperative healing after surgical removal of impacted third molar on patients who came to oral and maxillofacial surgery Department of Tehran Azad dental school and one private office in 1387. The study was a double blinded clinical trial design. It was hold on 19 patients at the age of 17-23 which were candidate for bilaterally impacted third molar extraction with the same difficulty index. Influence of modified triangular flap and buccal envelope flap were evaluated on dry socket and healing at 3 days and one week after surgery. changes in upon characteristics in two groups were analyzed with Mann u- Whitney and Fischer's exact Tests. Two of patients were excluded for different reasons and study were completed on 17 patients (34 sample). age of the patients were 19/941/5. 70/5 female, 47/1 had academic educations. Pederson difficulty index was 7-10. Incidence of dry socket in control and test groups were 41/17, 11/76, (P< 0/05). The average of healing at the 3rdday after surgery in control and test groups were 3/94 1/52, 0/82 0/73,(P< 0/001)and at the 7th day were 3/06 1/39,0/35 0/61,(P< 0/001). The modified triangular flap used in this study caused to decrease the incidence of dry socket and increase the healing at the 7th day after surgery of the mandibular third molars and the statistically significant differences was observed in dry socket and postoperative healing at the 7th day after surgery. In addition to the positive influence of modified triangular flap in the surgery of mandibular third molars in this study, it is suggested to evaluate the effects of this flap on incidence of dry socket and postoperative healing in the mandibular third molars surgery with a systematic review Research.

The role of 0.2% chlorhexidine in prevention of dry socket followed bysyrgical removal of third molars has been challenged by pervious research. The purpose of this study was to assess the efficacy of this gel on healing and pain after dental extraction at the OMFS Department of Islamic Azad University, school of dentistry. This experimental, double blinded study on 123 patients randomly into three groups which are as follows: First group: gel foam with 0.2% chlorhexidine gel placed into the alveolar socket. Second group: gel foam with placebo placed into the alveolar socket. Third group: no material placed into the alveolar socket. Pain level in the three groups after 24 hours and on days three was evaluated using a VAS scale and Healing process on the 3rd and seventh day was investigated with a healing scale. The incidence of dry socket was also evaluated using the diagnostic criteria specified by BLUM. Data were analyzed with Krusal Wallis, Mann-Whitney - U tests. Healing rate on the third and seventh days in the first group had significant statistical differences compared to the second and third groups(P<0.00). Pain rates on the first day and third day in the first group also had significant statistical difference compared to the second and third groups(P<0.00). Dry Socket was not reported in the first group. In second group and third group two cases and seven cases of dry socket were found respectively. Results from this study show that the use of 0.2% chlorhexidine gel after third molar extraction is effective in healing process, pain reduction and prevention of dry socket.