جستجوی مقالات مرتبط با کلیدواژه "بیماری لیکن پلان دهانی رتیکولر" در نشریات گروه "پزشکی"

the malignant transformation of types of erosive and atrophic oral lichen planus has been further studied. Epithelial growth factor receptor is an intramembranous receptor which is related to carcinogenesis. The aim of the present study was to determine the expression of EGFR marker in erosive and reticular oral lichen planus and oral epithelial dysplasia.

In this cross-sectional descriptive-analytical study, after specimens selection(20 erosive oral lichen planus(with no dysplasia), 20 reticular, 20 oral epithelial dysplasia lesion, 10 Inflammatory Fibrous Hyperplasia (control group)) Immunohistochemical staining with EGFR antibody kit was performed and mean percentage of stained cells with EGFR Marker, pattern of staining, intensity of staining and stained-cell place  in each sample was investigated simultaneously   by two oral pathologist. finally, Data obtained were analyzed using SPSS software (VERSION 20) and Kruskal–Wallis, Mann–Whitney and Fisher tests (Pvalue<0.05).

There was no significant difference between the mean percentage of stained cells in erosive and reticular oral lichen planus(Pvalue=0.213).while erosive lichen planus and oral epithelial dysplasia presented significant difference in this regard(Pvalue=0.017). There was no significant difference between the frequency distribution of staining  pattern in groups(Pvalue=0.16)also there was no significant difference between the intensity of staining and the stained-cell place in 4 groups(Pvalue=0.19 , Pvalue=0.90).

The expression of EGFR in patients with oral erosive lichen planus and oral epithelial dysplasia was higher than patients with oral reticular lichen planus and control group and it probably shows the higher potential of dysplastic changes in erosive lichen planus than reticular.