جستجوی مقالات مرتبط با کلیدواژه "تراکم عروقی 4" در نشریات گروه "پزشکی"

Angiogenesis is essential in the progression and metastasis of solid tumors. It has been proved that increase in angiogenesis within primary solid tumors is actually associated with nodal metastasis and risk prognosis of some malignancies. In contrast, regarding hematologic neoplasms very limited studies have been done. The goal of the present study was to determine MVD (Microvessel density) in acute leukemia and compare it with MVD in normal tissues. In this study 30 cases with acute leukemia and 30 normal controls were selected. These had been diagnosed and archived in the pathology department of Mashhad Ghaem hospital. Their blocks and slides were prepared and examined. After their final approving, the paraffin blocks were thinly sliced and the slices were immunohistochemically stained for VEGF (Vascular Endothelial Growth Factor) Immunohistochemical slides were evaluated for hot spots of MVD in the tissue in the microscopic field of vision with 400 times magnification. MVD or angiogenesis in acute leukemia was 20.2% which was obviously more than that in the controls (6.9%).The difference between the two groups was statistically significant (P<0.001). Angiogenesis in acute leukemia is significantly higher compared with the controls (who had normal tissues).But there was no significant difference between acute myeloid leukemia and acute lymphoblastic leukemia.

Retinoblastoma is the most frequent intra-ocular tumor in childhood. The tumor has both endophytic and exophytic patterns of growth. After enucleation, the pathologist is called on to evaluate risk of further growth for prophylactic therapy. Invasion of the choroid or optic nerve are risk factors for developing metastases, but occasionally, metastatic or locally invasive tumors occur in the absence of these risk factors. In this study, correlation of vascular density using CD31 with vascular endothelial growth factor(VEGF) and also both of these markers with local invasive growth of retinoblastoma were assessed. Patients and The study was analytical cross-sectional and performed on sections of paraffin-embedded blocks of 37 enucleated eyes due to retinoblastoma, at Ophthalmology Department of Hazrat Rasool Akram Hospital in years 2000-2006. Hematoxylin and Eosin stained slides were reviwed for evaluation of local invasive growth of tumor. Vascular density by CD31 and VEGF was assessed by immunohistochemical staining(IHC), using an Strept avidin-Biotin Immunoperoxidase technique. For data analysis, T test, Chi 2 test, Phi test and ROC curve were used. A CD31 number equal or greater than 62/10 HPF with 78.9% sensitivity and 66.7% specificity was considered as the most efficient cutt-off point and with VEGF as a qualitative test, were assumed as predictors for local invasion. Significant correlation was noted between VEGF and CD31. There was no correlation between CD31 and VEGF with uni or bilaterality, age, size and growth type. Assessment of vascular density with the use of CD31 and vascular endothelial growth factor(VEGF) can be useful method for prevention of local invasive growth of tumor and determining the need for prophylactic therapy in patients with advanced ocular retinoblastoma.