جستجوی مقالات مرتبط با کلیدواژه "تمرین استقاومتی" در نشریات گروه "پزشکی"

Today, cardiovascular diseases are one of the main causes of death. This study was conducted to compare the effect of resistance and endurance training on predictors of cardiovascular diseases and arteriosclerosis in aged male rats.

The present study is an experimental and fundamental research with a control group conducted in 2021 in the basic science laboratory of Shahrekord University in Iran. Fifty elderly male Wistar rats with an average weight of 432.7±4.4 grams and an age of 23±2 months were randomly divided into five groups. The control group was divided into two resistance training groups (climbing a special ladder) and two continuous training groups (running on a treadmill), and they did the training protocols for eight weeks and five sessions every week. Data analysis was performed using a one-way analysis of variance and Bonferroni post hoc test with SPSS 22 software at p≤0.05 level.

The results of the present study showed that the level of HDL increased significantly in all four training groups compared to the control group (p≤0.05). LDL level and LDL/HDL ratio decreased significantly in all four training groups compared to the control group (p≤0.05). The level of TC decreased significantly only in the high-intensity resistance training group (p≤0.05). Even though both training methods led to changes in the levels of TG, VLDL, ApoA1, ApoB, and ApoB/ ApoA1 ratio, these changes were not statistically significant (p>0.05). The difference between the two training methods was insignificant (p>0.05).

Both training methods caused positive changes in HDL, LDL factors, and LDL/ HDL ratio. Performing both training methods is recommended for older adults and people at risk, especially the military, although endurance training has more effect and fewer risks.

Brain derived neurotrophic factor (BDNF) have neuroprotective effect through binding with tyrosine kinase B (TrkB). Thus the Aim of the present study was to investigate the effects of eight weeks endurance training on BDNF and TrkB levels in the hippocampus of ischemic induced male rats.

40 Male wistar rats (12 weeks old and 228.19±21.18g) were divided into four groups, including: ischemic control, ischemic training, healthy control, healthy training. To induce ischemia, carotid artery is clamped with microsurgery clamp for 45 minutes. Training groups (healthy and ischemic), trained with 30m/min (70% VO2max), 30min/day, and 5 days/week on the treadmill. BDNF and TrkB levels of the hippocampus were measured using ELISA method.For data analysis, one-way ANOVA and post hoc Tukey tests were performed at a significance level of P˂0.05.

The results showed that BDNF levels in hippocampus of ischemic control group were significantly lower than healthy control and healthy training group (P values 0.001, 0.002 respectively). No significant differences were found between BDNF levels in ischemic training with ischemic control and healthy control group (p values 0.54, 0.091 respectively) and No significant differences were found between TrkB levels in ischemic control with healthy control and ischemic control group (p values 0.675, 0.821 respectively). TrkB level in healthy training group was significantly higher than healthy control, healthy training groups (P=0.001).

Based on these results, it seems that endurance training can have neuroprotective effect through increasing the level of BDNF and TrkB level in hippocampus of ischemic rats and can be studied as a complementary therapy in ischemic disease.