جستجوی مقالات مرتبط با کلیدواژه « تمرین مقاومتی هوازی » در نشریات گروه « پزشکی »

Parkinson's disease is a progressive and destructive disorder of the central nervous system. This study aimed to determine the effect exercise training and olive oil consumption on genes expression of the AKT¸ caspase3 and the spatial learning of rats with parkinson's disease

in this study, 30 rats were divided into 5 groups of 6: healthy control¸ parkinson´s control¸ parkinson´s+olive oil¸ parkinson´s+exercise training¸ parkinson´s+exercise training+olive oil.  The rats were fed 0.4 ml of olive oil daily for 8 weeks. Aerobic training was performed 5 days a week for 30 minutes and at a speed of 11 meters per minute. Resistance exercise begin with %30 of the rat´s weight and it reached %100 of the rat´s weight in the eighth week. The gene expression of AKT and caspase3 was measured through PCR-real time and spatial learning using radial maze. Data analyzed using one-way of variance and Thomhan's follow up test.

Increase in AKT genes expressin, reduced in caspase3 expression and spatial learning improvement significantly observed in exercise training and exercise training+olive oil compared to the parkinson's control group (P<0.05).

exercise training with and without olive oil consumpsion can be effective in improving spatial learning by increasing AKT and decreasing caspase3.

Parkinson's disease is a progressive neurological disorder associated with the destruction of dopaminergic neurons in the substantia nigra. Physical exercise can control the risk of neuronal damage. The compounds of olive oil have a modulating effect on the activity of the brain cholinergic system. The present study aimed to investigate 8 weeks of combined aerobic resistance training with olive oil consumption on the balance and some apoptotic genes of the substantia nigra of the brain in Parkinsonian rats.

Forty- eight male rats were divided into 8 groups (n=6). 6-Hydroxydopamine was used to induce Parkinson's disease. Olive oil (0.4ml/daily) was fed for 8 weeks to the target group. Thirty minutes aerobic exercise was performed on a treadmill at a speed of 11 meters per minute with an intensity of 60 to 65% of VO2max. Resistance exercise started by climbing a ladder with weights to the rat's tail with 30% of body weight, which reached 100% of body weight at the end of the eighth week. To check the balance of the mice, a balance bar was used; the expression level of genes was measured using Real time-PCR method. Statistical analysis was performed using one-way analysis of variance and Thomhan's post hoc test at a significance level of p<0.05.

A significant increase in PINK-1and AKT gene expression levels and a decrease in caspase-3 and p53 gene expression levels were observed in the exercising group, exercising with and without consuming olive oil and corn oil compared to the Parkinson's group (p=0.001). However, there was no significant difference between these three groups (p>0.05). Balance improvement was observed in rats with exercise and olive oil consumption compared to the parkinsonian group (p=0.001).

8 weeks of combined resistance-aerobic training causes a significant increase in the expression level of AKT and PINK1 genes and a decrease in the expression level of caspase-3 and P53 genes in Parkinsonian rats. Also, this type of exercise, along with the consumption of olive oil improves balance in Parkinsonian rats.

Coronary Heart Disease (CAD) is one of the most important causes of mortality. Exercise activities after coronary artery bypass surgery increase the density of myocardial capillaries called angiogenesis and improve cardiovascular function. The aim of the present study was to determine the effect of aerobic-resistance training on plasma basic fibroblast grown factor levels in post-coronary artery bypass grafting patients.

Methods & Materials: 

The sample consisted of 30 men aged 45-60 years who underwent bypass surgery. They were randomly divided into experimental (n=15) and control (n=15) groups. The experimental group performed aerobic resistance training for eight weeks (3 sessions per week) and the control group did not. Blood samples were taken 24 hours before the start of the first training session and 48 hours after the last training session while all subjects were fasting. In vitro ELISA method was used to measure BFGF. Independent and paired t-test and Shapiro-Wilk test were used to analyze the data at the significant level of 0.05 in SPSS v. 21.

Ethical Considerations:

 This study was registered (Ethics Code: IR.IAU.NEYSHABUR.REC.1398.01) in the Ethics Committee of Islamic Azad University, Neishabour Branch, and with Clinical Trial Code: IRCTID:IRCT20191228045919N1.

 Eight weeks of aerobic-resistance training significantly increased bFGF levels in the exercise group compared to the control group (P=0.002). Also, pre and post changes in the experimental group showed a significant increase in plasma bFGF levels (P=0.002), which was not significant in the control group (P=0.758).

 According to the results, it may be concluded that combined (aerobic resistance) exercise may increase angiogenesis and capillary density in post-CABG patients by increasing plasma bFGF levels