جستجوی مقالات مرتبط با کلیدواژه "خوشاریزه" در نشریات گروه "پزشکی"

Diabetes mellitus is a systemic metabolic disease that is specified by hyperglycemia, hyperlipidemia, hyperaminoacidemia and hyperinsulinemia. This study aimed to assesses the effects of extracts of aerial sections of Echinophora platyloba on function tests of liver, kidney, and fat profiles of diabetic male rats induced by Streptozocin.

45 head male rat were divided into 5 diabetic control groups and 3 case diabetic groups that received alcoholic extracts of Echinophora platyloba in the doses of 75, 150, 300 mg/kg in the form of gavage. Diabetes induction was performed using intraperitoneal injection of streptozotocin with the dose of 50 mg/kg. Blood samples were taken from all groups at the end of day 21 and the rate of the factors were measured and analyzed.

The rate of ALP, SGPT, HDL, LDL, cholestrol, uric acid and creatinine indicated a significant change. The rate of triglycerides and albumin indicated a decreasing and an increasing significant change than the control group, respectively. The rate of BUN and total protein indicated a decreasing and an increasing significant change than the control group, respectively. The rate of SGOT in the case group receiving the minimum extract dose (75mg/kg) indicated a decreasing significant change than the medium extract (150mg/kg).

The extract of Echinophora platyloba especially in the low doses causes hepatoprotective and hypolipidemic due to its antioxidant properties and increase in thyroid hormones. Moreover, some studies indicate the side effects of the extract to some organs. So, its consumption should be used in suitable doses.

By increasing consumer demands for food products with no chemical preservatives, use of natural preservatives such as herbs with antioxidant and antimicrobial characteristics as well as effects on physicochemical and sensory characteristics of the products is increasing in food industries. Therefore, the objective of this study was to investigate effects of Echinophora platyloba on microbial, physicochemical and sensory characteristics of pickled cucumbers.

In this study, effects of Echinophora platyloba powder at 1, 2 and 3% on physicochemical (pH, titrable acidity, salt, color and texture), sensory (odor, smell, texture, taste and appearance) and microbial characteristics of pickled cucumbers were assessed during 14 days of storage at ambient temperature.

Results showed that with increasing the proportion of plant powder, pH and firmness of the cucumber samples increased and salt and acidity decreased (p ≤ 0.05). Based on the results of sensory assessment, samples containing 2% of Echinophora platyloba powder were more acceptable than other samples. As the proportion of powder increased, color values ​​of L* and b* decreased but the color value of a* increased. Microbial assessment results showed a significant antimicrobial activity of Echinophora platyloba powder; hence, no fungal and bacterial growths were seen in samples containing 3% of the powder.

In conclusion, Echinophora platyloba can be used as a natural preservative and a substitute for potassium sorbate in preservation of pickled cucumbers.

Carbon tetrachloride is one of the chemical toxins widely used in hygiene industries. The aim of this study was to investigate the effects of Echinophora platyloba extract (EPE) on serum levels of testosterone and gonadotropins in male rats induced with carbon tetrachloride.
In this experimental study 49 male Wistar rats (220-250 g) were randomly divided into seven groups (n=7): Control group (2 ml/kg normal saline, daily for 4 days, ip), toxicant group (2 ml/kg CCl4ꉘ oil.1:1, single dose ,ip), sham group (2 ml/kg olive oil, single dose, ip), positive control group (400 mg/kg EPE daily for 4 days, ip), toxicant-treated groups 1, 2 and 3 (CCl4 olive oil.1:1, single dose and 200 and 400 and 800 mg/kg of EPE, respectively, daily for 4 days, ip). At the end of the treatments, serum testosterone and FSH & LH hormones were measured.
CCL4 resulted in significantly decreased testosterone and increased FSH & LH serum levels in the toxicant group compared with the control group (P Hydro-ethanolic E. platyloba extract increased serum levels of testosterone and decreased FSH and LH serum levels in male rats induced with CCL4.

In traditional Iranian medicine, use of medicinal herbs is prevalent for the treatment and alleviation of pain and inflammation. Echinophora Platyloba is one of the major medicinal herbs with confirmed anti-cancer, anti-microbial, and anti-fungal effects. Therefore, in this study, we aimed to evaluate the analgesic effects of E. platyloba hydroalcoholic extracts in male rats.
In this experimental study, 42 rats were divided into six groups, i.e., control group, extract groups (80, 100, and 300 mg/kg via intraperitoneal injection), morphine group (1 mg/kg via intraperitoneal injection), and naloxone group (1 mg/kg of naloxone along with 300 mg/kg of the extract). To evaluate the analgesic effects of the extracts, rating, tail flick, and formalin tests were performed.
FINDINGS: In the writhing test, doses of 100 and 300 mg/kg of the extracts could decrease the rating score from 43.3±22.61 to 27.31±2.34 (p According to the present results, E. platyloba hydroalcoholic extracts have central and peripheral analgesic effects.

Obesity and its complications such as hypertension, fatty liver, type 2 diabetes and kidney failure, can be mentioned as the main life-threating elements. Therefore, this study aimed to evaluate the effect of air parts extract of Echinophora platyloba.L (EP) on changes in body weight as well as liver and kidney function tests in hypercholesterolaemia obese rats. In this experimental study, 40 male Wistar rats were divided in to five groups (n =8) including a control group with normal control diet, control hyperlipidemia group with fatty food diet and hypertriglyceridemia treatment groups which recieved the minimum dose (100 mg/kg), average dose (200 mg/kg) maximum dose (300 mg/kg) of EP extract via a gavage. At the end of this period (42 days), to measure cholesterol, creatinine, blood urea nitrogen, bilirubin, albumin, total protein, alanine Aminotransferase (ALT) and aspartate Aminotransferase (AST) and alkaline phosphatase (ALP), the blood samples were collected and the study data were analyzed. Cholesterol, ALT, AST and ALP were reported to significantly decrease (in the minimum and maximum dose groups) compared to the control group (P≤0.05). Albumin and total protein in the maximum dose extract group significantly increased compared to the control group (P≤0.05). Moreover, body weight in the group receiving the minimum dose of extract showed a significant decrease compared to the control group (P≤0.05). EP extract, specifically in the minimal doses, in addition to protecting liver, could be recommended as a good candidate in regard with the treatment of blood lipids, and body extra weight.

Echinophora cinerea is a plant of the Apiaceae family, which reaches to a height of 30 to 100 cm. The essential oil of Echinophora cinerea contains alkaloids and flavonoids etc. Phenolic composition is one of the best sources of natural antioxidants. The goal of this study is to examine the antibacterial and antioxidant activities of the essential oil of E. cinerea. In order preparation and identification of chemical compounds of essential oils, hydrodistillation approach and gas chromatography coupling with a mass spectrometer (GC, GC-MS) were used. Antioxidant capacity of the essential oil was determined by DPPH assay and, compared with standard antioxidants (BHT). Antibacterial test had done by broth microdilution and disk diffusion methods, and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of these oils after 24 and 48 h were determined and compared to antibiotic standards against food-borne pathogens including Staphylococcus aureus, Listeria monocytogenes, Pseudomonas aeruginosa, Escherichia coli and MRSA. Results of GC and GC-MS showed that the major components of essential oil of E. cinerea were α-phellandrene (32.09%), limonene (16.28%), p-cymene (10.75%), α-pinene (9.79%), carvacrol (3.79%) and β-myrcene (2.65%). Results of antioxidant test indicated that IC50 for oil of Echinophora cinerea was 740 μg/ml while for BHT was 50.6 μg/ml. The highest antibacterial effects of essential oil were observed on standard bacteria of Staphylococcus aureus with MIC= 0.16 μg/ml and MBC= 0.63 μg/ml. This effect on MRSA-resistant Staphylococcus and E. coli was weaker. Pseudomonas aeruginosa was resistant to essential oil. According to results of present study, the essential oil E. cinerea can be used in the food, pharmaceutical, cosmetic and health industry and flavoring.

Dysmenorrhea occurred in about fifty percent of women with regular menstruation. Different methods were applied for treatment and medications with lower side effects are preferred. Aim of this study was to detect the effect of echinophora-platyloba on primary dysmenorrhea in students. This single blind clinical trial was carried out in single students with primary dysmenorrhea in the Shahrekord University of Medical Sciences. Sixty students were randomly divided into two groups receiving; the echinophora-platyloba extracts or placebo. Visual analogue scale was used to detect the severity of desmenorrhea. At the end of first and second month after intervention, the severity of pain was assessed and compared with before intervention. Data was analyzed by SPSS software using chi-square, t and mann-whitney tests and P.

Premenstrual syndrome(PMS) is a condition characterized by a number of behavioral, psychological and physical symptoms recurring cyclically during the luteal phase of the menstrual cycle. The uncertainty in the pathogenesis of PMS has led to many treatments being suggested as possible therapies. This study was carried out to compare the effects of Echinophora-platyloba and Fennel extracts on the PMS. In this single, blind randomized clinical trial, ninety students with moderate to severe PMS were divided into three groups of thirty students, each. The first group received E.platyloba extract, the second received Fennel extracts and the third group received Placebo. The severity of PMS was detected by Daily Record Of severity of Problems(DRSP) questionnaire at the end of first and second month after the intervention and compared with the results before intervention. Data analysis was performed by SPSS, One-Way Anova, Dunn and Wilcoxan tests and P<0.05 was considered significant. The Mean premenstrual syndrome scores were similar in three groups before the intervention [(100.8±22.1 in Echinophora platyloba group, 101.3±33.4 in Fennel group and 104.3 ±19.5 in Placebo group), P=0.58)], but there was a significant difference between them after the intervention and the effects of E.platyloba and Fennel extracts in reduction of symptoms was greater than the placebo[(49.7±23.2 in E. platyloba group, 64.43±29.3 in Fennel group and 79.1±28.1 in Placebo group), P=0.009)]. There was no significant difference between the effects of E. platyloba and Fennel. As E. platyloba and Fennel extracts reduce the symptoms of PMS significantly, their use is advisable in PMS patients.

Premenstrual syndrome (PMS) disrupts young women’s normal life and activity each month. Different methods have been employed for treatment of PMS. The aim of this study was to detect the effect of Echinophora platyloba on premenstrual syndrome in students of Shahrekord University of Medical Sciences in 2008. A single-blind randomized clinical trial was performed on sixty students with PMS. They were randomly assigned to receive either the Echinophora platyloba extract or placebo; the DRSP questionnaire, (daily record of severity of problems) was used for data collection. At the end of first and second month after intervention, the severity of PMS was recorded and compared with symptoms prior to intervention in the two groups. Data was analyzed by SPSS software, P<0/05 was considered significant. The severity of premenstrual syndrome was similar in two groups before intervention (Score=100.8±22.1 vs. 104.3±19.5), but after the intervention, there was a significant difference in severity score between the 2 groups viz. 49.7±13.2 vs. 79.1±18.1 in the intervention vs. the control group respectively, (p=0.002). Echinophora platyloba extract is effective in the treatment of premenstrual syndrome.

Introduction & Dysmenorrhea nearly occurs in five percent of women with regular menstruation. Different therapeutic methods were performed for the treatment of dysmenorrhea and obviously a method with the fewest side effects is preferred. The aim of this study was to compare the effects of echinophora-platyloba with fennel on the primary dysmenorrhea. This clinical trial was carried out in sixty unmarried students with mild and moderate dysmenorrhea in Shahrekord University of medical sciences. The students were randomely selected and classified into two equal groups one of twitch received echinophora-platyloba and the other fennel extracts. The severity of pain was detected by the visual analogue scale during two cycles before and two cycles after the intervention. The data was analyzed by spss software, t-test, chi-square and Pearson correlation tests and P<0.05 was considered significant. There was no significant difference in the mean of dysmenorrhea severity during the two cycles before the intervention between the two groups, but during the two cycles after the intervention, both drugs could reduce the severity of dysmenorrheal. However, this reduction was lower in recipients of echinophora-platyloba extract than the recipients of fennel extract and the difference was significant (P<0.001). Echinophora-platyloba and fennel extracts could reduce the dysmenorrhea during the intervention and the effects of fennel were greater than echinophora-platyloba so the consumption of fennel extract is suggested for dysmenorrhea.

Dysmenorrhea is seen in nearly 5% of women with regular menstruation. In this regard, different methods have been proposed for treatment of dysmenorrhea, and drugs with fewer side effects are preferred. Hence, this study was done to detect the effect of echinophora- platyloba on primary dysmenorrhea. In a single-blind clinical trial, 60 students with primary dysmenorrhea were evaluated at Shahr-e-Kord University of Medical Sciences. The students were randomly divided into two groups of 30 each: Echinophora-platyloba extract and placebo. Data collection was done through visual analogue scale for detecting the intensity of pain. At the end of first and second months after treatment, the intensity of pain was determined in the two groups and compared with that before the intervention. Eventually, the data were analyzed through Chi square, t-test and Mann-Whitney test. The means of dysmenorrhea severity scores two months before administering the drug in echinophora-platyloba and placebo groups were 8.46±2.75 and 8.80±2.53, respectively. Here the difference was not significant; however, after administering the drug, the mean scores in intervention and non-intervention groups were 3.41±1.12 and 7.82±2.60, respectively, which indicated a significant difference between the two groups (p<0.001). Both echinophora-platyloba extract and the placebo could reduce the severity of dysmenorrhea during the treatment, yet the effect of echinophora-platyloba was much greater than the placebo. Thus, the use of echinophora-platyloba extract is suggested in treatment of dysmenorrhea.