جستجوی مقالات مرتبط با کلیدواژه "خونریزی قاعدگی" در نشریات گروه "پزشکی"

  The rate of bleeding is associated with impaired synthesis of endometrial prostaglandins, especially PGE2. One of the most common causes of anemia in women is menstrual bleeding. Bromelain, an enzyme found in pineapple, has anti-inflammatory effects and reduces prostaglandin E2 in inflammatory regions. This study was performed with aim to compare the effects of Bromelain and Mefenamic acid on the amount of menstrual bleeding. A double-blind randomized clinical trial was conducted on 90 students with primary dysmenorrhea in dormitories of Velayat University of Iranshahr in 2017. The students were monitored for two cycles with Higham chart in terms of the rate of bleeding. Then, they were randomly assigned to two groups: Bromelain (n=32) and Mefenamic acid (n=34). The Higham chart was completed to measure menstrual bleeding in two cycles of control and two cycles of intervention. The subjects received 250mg capsules of Bromelain or 250mg capsules of Mefenamic acid, if needed, they received two interventional cycles every 6 hours during the first three days. Data was analyzed by SPSS software (version 22) and Mann-Whitney, Paired t-test and independent t-test. P <0.05 was considered significant. The results of Paired t-test showed significant difference in the amount of bleeding after intervention in the Bromelain group (P = 0.036), but this difference was not significant in the Mefenamic acid group (P = 0.088). The difference between the mean of bleeding in two cycles of intervention compared to the two cycles of control was -6.79 ± 17.57 in the bromelain group and was -5.36 ± 17.57 in the Mefenamic acid group that showed no significant difference (P = 0.744). Consumption of Bromelain for reducing menstrual bleeding has no difference with Mefenamic acid in primary dysmenorrhea.

Nigella sativa is one of the plants traditionally used in the treatment of dysmenorrhea, but its effect on menstrual hemorrhage has not been reported. Therefore, this study was performed with aim to compare the effects of Nigella sativa and mefenamic acid on menstrual hemorrhage.
This double-blind clinical trial was performed on 70 students with primary dysmenorrhea who were resident dormitories of in Mashhad University of Medical Sciences in 2014. The patients were randomly assigned to two groups of mefenamic acid and Nigella sativa. The research was conducted in two stages. At first, all the students were followed for two cycles in terms of bleeding, and then each of the patients randomly received Nigella sativa or mefenamic acid capsules for two consecutive cycles. Data were analyzed using SPSS software (version 16), and independent t-test and Friedman test. P Mean bleeding before the intervention in nigella sativa group was 85.20 ±37.85 cc that increased to 85.62 ± 34.2 in the first and to 85.77 ± 31.81 in the second cycle of treatment. Mean bleeding before the intervention in mefenamic acid group was 83.77 ±38.31 and decreased to 78.05 ±32.66 in the first and to 76.85 ± 29.71 in the second cycle of treatment. Overall, two groups were not statistically significant in terms of bleeding in the first and second cycle of treatment (P Use of Nigella sativa can increase the amount of menstrual bleeding, but this increase was not significantly different with mefenamic acid.

Menstrual disorders can cause many problems for women at different periods، and sometimes diagnosis and treatment of these disorders manifests as a problem in clinical medicine. Due to the high prevalence of menstrual disorders and fewer side effects of herbal medicines than chemical drugs، this study was performed with aim to compare the effects of chamomile and mefenamic acid capsules in hemorrhage of menstruation. This triple-blind randomized clinical trial study was performed on 90 students living in dormitories of Kashan University of Medical Sciences. They were randomly divided into two groups of chamomile and mefenamic acid. 45 cases received 250 mg of chamomile and 45 cases received 250 mg mefenamic acid per 8 hour for two cycles. Data collection tool was questionnaire، and Higam standard test was used to determine bleeding. Data was analyzed by SPSS statistical software (version 16)، and Chi-square test، T-test، Fisher and paired t-test. The amount of bleeding was significantly decreased in both treatment groups compared to pre-treatment (P<0. 05)، but the difference between two groups was not significant (P>0. 05). Decreased amount of bleeding caused by chamomile and mefenamic acid was not different in the second cycle compared to first cycle (P>0. 05). The use of chamomile capsule can decrease hemorrhage in menstruation، so its consumption is recommended to treat this disorder in women.

Unusual menstrual bleeding is one of the most common side effects of IUD. Considering public enthusiasm to the use of herbal medicine, this study conducted to compare the effects of cumin and mefenamic acid capsules on menstrual bleeding in IUD users. This crossover triple-blind randomized clnical trial study was performed on 100 IUD users who came to 6 health centers in Karaj. Research took place in three stages. In the first stage menstrual bleeding was measured by using Hygam table. In the second stage all participants were randomly allocated to mefenamic acid and cumin groups. They took capsules for two consecutive cycle. In the third stage each research unit received the same treatment of the opposite group with replacing the medicine for two more consecutive cycle. Menstrual bleeding was assessed by using Hygam table for 5 cycle. Considering that the maximum efficacy time for cumin was 24 hours and for Mefenamic acid was6 to 8 hours, the use of drugs in 7 days during menstruation, had no effect on subsequent cycles. Data, was analyse by Chi-square and Fisher's exact test, paired t-test, Wilcoxon. The mean of menstrual bleeding was 154.26±60.08 and after treatment was 106.68±45.38 and 105.8±40.56 in the mefenamic acid and cumin groups. There was a significant difference in decrease of pain intensity in both groups (p<0.001). There wasn’t a significant difference in decrease of pain intensity between two groups. This study showed that cumin same as mefenamic acid capsules can decrease menstrual bleeding effectively. Therefore it is recommended to use it in the treatment of menstrual bleeding in IUD users.

Early dysmenorrhea is a painful menstruation which happens without any pelvic pathological disorder and about 80% of women experience it. The purpose of this study was to investigate the effect of eight-week aerobic exercise trainings and detraining on the severity of dysmenorrhea and the amount of menstrual blood flow in non-athlete students. This study was semi-experimental in which sixty subjects were selected from students of Lorestan universities. After evaluating health status, early dysmenorrhea diagnosis and severe menstrual blood flow, the subjects were randomly divided into two equal control and exercise groups. The experimental group participated in an eight-week aerobic exercise training, three sessions per week. The severity of dysmenorrhea and the amount of menstrual blood flow were measured before and after exercise training and also after 48 days of detraining. Repeated measures of ANOVA and Cochran Q were used to analyze data. The aerobic exercise training significantly decreased early dysmenorrhea and menstrual blood flow in experimental group (p=0.001), but the positive effect of aerobic exercise training on the dysmenorrhea and menstrual blood flow was totally disappeared after 48 days of detraining (p=0.000). It seems that performing regular aerobic exercise training can be used as a preventing, treating or supplementary treating method in control of the early dysmenorrhea and the severe menstrual blood flow in non-athlete students.

Considering the prevalence of dysmenorrhea and its importance for women as well as social qualities and public tendency toward alternative complementary and herbal drugs, this study was carried out to determine the effect of Menastil on primary dysmenorrhea on students residing in Dormitories’ universities of Saveh 2005. This placebo-controlled double-blind clinical trial was performed on 72 single students between 18 and 26 years old with primary dysmenorrhea. Data were collected through a questionnaire which included demographic factors, exercise, stress factors, use of medicines, and the McGill pain ruler for determining of pain severity. Subjects were classified into two groups of moderate (4≤ Score ≤7) and sever (8≤ Score ≤10), base on their pain severity. Subjects with scores of less than 4 were excluded from this study. All Subjects randomly allocated into two groups (1) the experimental group who received the vials of Menastil and (2) the placebo group. Two drops of Menastil (calendula+mint) was used topically during the menstruation in the form of an abdominal massage for two months. The placebo group received the same mode of treatment with the vials contained baby oil and mint. The menstrual cramp levels were assessed, using a visual analogue scale (McGill Ruler) and severity of dysmenorrhea was measured by a verbal multidimensional scoring system. Data were analyzed applying Freedman and Mann-Whitney statistical tests. Demographic characteristics (age, height, weight & menstrual status) were similar between two groups. The score of dysmenorrhaea reduced in both groups. The results showed that compared to placebo, Menastil decreased more the severity of dysmenorrhea so that the difference between two groups was significant (P<0.0001). Also, the consumption of pain relief agents and the amount of menstrual bleeding decreased by Menastil therapy. Moreover, there was no side effect with this mode ot treatment. The consumption of menastil decreases primary dysmenorrhea. The investigation of effects of long term consumption of menastil (6 months) is recommended.