جستجوی مقالات مرتبط با کلیدواژه « درماتیت سبورئیک » در نشریات گروه « پزشکی »

Seborrheic dermatitis is one of the most common inflammatory skin diseases that affect the sebaceous glands. Although the exact role of vitamin D in this disease is still not clearly understood, some studies have shown lower serum levels of vitamin D in seborrheic dermatitis patients. This study aimed to investigate the correlation between vitamin D deficiency and seborrheic dermatitis.

This cross-sectional case-control study was conducted in Sina Hospital, Hamadan, Iran. The study sample included 39 seborrheic dermatitis patients (case group) and 39 healthy individuals (control group) who were matched in terms of gender and age. The groups were then compared regarding serum vitamin D level. Statistical analysis was performed in SPSS software (version 16.0; SPSS Inc.Chicago, IL).

There were no significant differences between the two groups in terms of age, gender, educational level, place of residence, and occupational status. The mean serum levels of vitamin D in the case and control groups were 11.82±5.56 and 21.38±6.79ng/ml, respectively (P=0.001). Furthermore, in the case and control groups, 18 (46.2%) and 1 (2.6%) individuals had vitamin D deficiency; 20 (51.3%) and 34 (87.2%) cases had inadequate vitamin D levels; and 1(2.6%) and 4 (10.3%) subjects had adequate levels of vitamin D, respectively. Therefore, the serum level of vitamin D was significantly lower in the case group, compared to the control group (P=0.001). Moreover, the serum level of vitamin D did not correlate with the duration and severity of seborrheic dermatitis disease (P>0.05).

According to the findings of this study, patients with seborrheic dermatitis had lower serum vitamin D levels, compared to the general population, which may be related to the pathogenicity of the disease.

Seborrheic dermatitis is a chronic inflammatory skin disease. Inflammation is one of the components of metabolic syndrome and many inflammatory cytokines play a critical role in this disease. The aim of this study was to investigate correlation between seborrheic dermatitis and metabolic syndrome.

In this case- control study 39 seborrheic dermatitis patients who referred to Sina Hospital of Hamadan as case group and 39 age and sex matched healthy individuals as control group were compared in terms of metabolic syndrome. Statistical analysis was performed using version 16.0 (SPSS Inc. Chicago, IL).

High-density lipoprotein (HDL) levels in the patient group were statistically significantly lower than in the controls (in women P=0.046 and in men P=0.044). Mean of triglyceride, cholesterol, low-density lipoprotein(LDL), fasting blood glucose (FBS), systolic and diastolic blood pressure and waist circumference in case group were more than in control group but just systolic blood pressure and waist circumference were statistically significant (P<0.05). In case group 20.5% and in control group 7.7% were afflicted metabolic syndrome which was not statistically significant (P=0.104).

Some significant parameters of metabolic syndrome in seborrheic dermatitis patients may be a predictive factor for screening.

Seborrheic dermatitis is a common inflammatory skin disease characterized by erythema, scaling, and pruritus. Antifungals are among the most commonly prescribed drugs for the treatment of this disease. In this regard, the present study investigated the efficacy of two medications including clotrimazole 1% and sertaconazole 2% in the treatment of adult seborrheic dermatitis.

This double-blinded randomized clinical trial was performed on 100 patients over the age of 18 with seborrheic dermatitis referring to Farshchian hospital, Hamadan, Iran. Patients were randomly assigned to two groups. The participants in one group received sertaconazole twice a day for four weeks and another group received clotrimazole within this period of time. After two weeks, the patients were examined in terms of clinical symptoms and side effects of medications. Moreover, they were reexamined for recurrence of disease after the completion of treatment and four weeks later. Furthermore, the level of patients' satisfaction was evaluated four weeks after treatment.

Mean and standard deviation of Scoring Index 7.16±2.20 and 6.45±2.10 before treatment (P=0.184), 4.08 ± 1.82 and 2.78 ± 2.14 two weeks after treatment (P<0.001), and 2.62 ± 2.13 and 0.89 ± 1.09 four weeks after the end of treatment (P<0.001). Additionally, the relapse rate in clotrimazole and sertaconazole groups was found to be 32% and 21.7%, respectively. Furthermore, the complication rate was reported as 8% and 8.5% in clotrimazole group and sertaconazole group, respectively (P=0.220). Moreover, the rate of good satisfaction in clotrimazole and sertaconazole groups was reported as 38% and 71.1% (P<0.001), respectively.

Based on the results of the study, the frequency of complications and recurrence of disease in patients treated with sertaconazole was comparable to treatment with clotrimazole. However, sertoconazole was found to be more effective and bring more satisfaction to patients.

Seborrhoic dermatitis is one of the most common diseases in dermatology with a prevalence of about 2%. Many treatments have been used for this disease. This Study aimed to investigate the efficacy of betamethasone lotion compared with clotrizone lotion in patients with seborrheic dermatitis of face and scalp.

This double blind study was performed on 60 patients with  seborrheic dermatitis older than 18 years, who refered to Emam Reza hospital, Mashhad. Patients were divided into two groups: clotrizone (31) and betamethasone group (29 patients). Patients were treated for a month. We evaluated severity of pruritus, erythema and desquamation of the face and scalp.

The average age of patients participating in the study was 33.1 years (18 to 56 years) and 56.7% of patients were male. No significant differences were found in age and gender between the two groups (P> 0.05). Both treatments reduced severity of erythema and desquamation of the face and scalp (P<0.001). Two weeks after treatment, clotrizone had better performance, but there after both lotions had similar effect. Betamethasone reduced pruritus more than clotrizone.

This study showed that both  betamethasone and clotrizone  were effective. Clotrizone has better impact on the severity of erythema and scaling and betamethasone has better effect on improving the severity of pruritus.

Dandruff and seborrheic dermatitis (SD) are common chronic skin diseases. There are many chemical drugs for treating dandruff and SD. Prolonged use of them may cause side effects and drug resistance. The aim of this study was to compare the efficacy of a herbal extract lotion with clotrimazole 1% lotion in the treatment of SD.
Twenty volunteers (12 men and 8 women) aged 20 to 40 years, with seborrheic dermatitis were enrolled in this trial and were randomly allocated into two groups. One group was treated with a herbal extract lotion and the other group with clotrimazole lotion. The herbal extract contained common sage, thyme vulgaris, tea tree oil, lavender, willow, rosemary, and aloe vera. The patients were instructed to use the lotions three times a week for 4 weeks. We evaluated the patients by clinical assessment and measured the scalp sebum, pH, and dandruff number before two weeks, and four weeks after completed a treatment. At the end of the study, each participant satisfaction form.
At the end of the study, the participants whom received the herbal extract lotion had a significantly greater reduction in scalp scaling, erythema, itching, and number of dandruff compared with those who received clotrimazole (P This study showed that herbal extracts lotion was effective in the treatment of dandruff and seborrheic dermatitiand can be an appropriate alternative to chemical agents.

Malassezia species (previously Pityrosporum) are normal flora of human and warm-blooded animals skin. The genus Malassezia is now divided into 13 species. Most of the yeasts show an absolute requirement for long fatty acid chains and specific procedures are required for their isolation, conservation and identification. Under appropriate conditions, the fungi can cause various skin diseases. The aims of this review were to describe recent classification of genus Malassezia; their virulence factors, and their association to dermatlogical diseases.

Malassezia that is a part of normal flora is lipophilic yeast involved in a variety of skin diseases such as seborrheic dermatitis, pityriasis versicolor, atopic dermatitis and psoriasis. Seborrheic dermatitis affects most often the sebaceous-gland-rich areas of skin such as face, scalp, and parts of the upper trunk. Dandruff is a mild variant of seborrheic dermatitis characterized by scaling. In this study, Malassezia species causing dandruff were identified.

In this descriptive study, the samples (n= 60) from participants with dandruff were examined under a microscope using 10% KOH solution and cultured in Leeming and Notman ager medium. DNA Extraction was performed from colonies by glass bead and the Malassezia genus, and species were detected by CfoI enzyme using PCR-RFLP method

Of 60, 40 (66.6%) were positive for Malassezia yeast. The positive samples in direct examination grew in culture medium. Malassezia species isolated were Malassezia globosa (25 cases), Malassezia restricta (10 cases), Malassezia furfur (3 cases) and Malassezia sympodialis (2 cases).

In most studies, the Malassezia species were identified as the agents causing seborrheic dermatitis. In our study, Malassezia globosa was isolated as a dominant species.

Seborrheic dermatitis is a chronic dermatitis that has been observed in both neonates and adults. It has been reported following stress, decreasing of mental and somatic energy, tiredness, insomnia, excitability, depression, etc. All of mentioned effects have adverse effects on health activity and result in body weakness. The aim of this study was evaluating general health indices of Arak Islamic Azad university students that suffered from seborrheic dermatitis using Goldberg scale. Three hundred and eighteen students were randomly selected and examined, among them 101 students who suffered from seborrheic dermatitis completed the General Health Questionnaire and then the data were statistically described and analyzed. Forty-one percent of students with seborrheic dermatitis had body symptoms. Anxiety, communicative act failure and depression were observed in 48%, 65% and 31% of patients, respectively. The findings of this study indicated the strong relationship between seborrheic dermatitis and communicative act failure.

Malassezia is a lipophilic and dimorphic fungus which has different species. Some of them can be found as natural flora on the skin and in some conditions may cause seborrheic dermatitis. The aim of this study was to identify Malassezia species associated with seborrheic dermatitis in Iranian patients, using PCR-RFLP.

In this study out of 79 patients with seborrheic dermatitis, isolates of 70 patients were positive for Malassezia species using PCR-RFLP. The Internal Transcribed Spacer 2 (ITS2) region was amplified by PCR employing the ITS3 and ITS4 primers and The restriction endonucleases AluI, BanI and MspAI were selected for producing distinct RFLP patterns.

M. globosa (48.6%), M. furfur (40.0%), M. slooffiae (8.6%) and M. sympodialis (2.8%), were the microorganisms responsible for the infection among participants. M. pachydermatis, M. japonica, M. dermatis, M. restricta, M. obtuse, M. nana and M. yamatoensis were not isolated from any samples.

Our findings suggest that the most common Malassezia species associated with seborrheic dermatitis was M. globosa, followed by M. furfur.

Pruritus is usually caused by a primary skin disorder or a systemic disease. Causes of groin pruritus are fungi, eczema, bacterial diseases, neurodermatitis, scabies and many other skin disorders. This study was performed to find the common causes of groin pruritus in female patients that referred to dermatology and gynecology clinics of Yahya-Nejad hospital in Babol. This descriptive study was performed on patients with groin pruritus from the begining of winter 2006 until the end of autumn 2007. Other information including name, age, height, weight, previous drug consumption, simultaneous infection in partner or other members of the family, duration of infection, underlying disease and result of examination were recorded in a questionnaire for each patient. 115 patients were studied. The average age of patients was 41.2 years (15-75 years old). The highest disease frequency was seen in 48 cases (41.7%) in summer. Most cases (33 patients [28.7%]) were between 46-55 years of age. Most of patients (28.7%) had a BMI from 25 to 29.9 (over weigh). The most common causes of groin pruritus in all seasons, ages and BMIs were tinea cruris in 55 cases (47.8%) and seborrheic dermatitis in 29 cases (25.1%) Considering common causes of groin pruritus, season and patient’s weight can be helpful in diagnosis and early treatment of groin pruritus.

Evidences shows that the defect in the synthesis of some fatty acids can lead to seborrheic dermatitis and elevated serum lipids in lipophilic fungi activities. Epidemiologic reports suggest a relationship between antioxidant levels and serum liplds in a number of dermatitis. This study was carried out to determine the relationship between antioxidant levels of plasma and serum lipids with seborrheic dermatitis. Methods and Materials: In this case-control study 70 patients suffering from SD were compared with 70 healthy people as control group. The two groups had been matched in terms of age and sex. Lipid levels and plasma antioxidants were measured by FRAP (Ferric Reducing A Bility Of Plasma Assay) in both groups. In patients skin lesions samples were tested through web spread to confirm the diagnosis and severity of pityrosporum ovale. The collected data was analyzed by SPSS software, T-Test and Chi-Square tests. The mean level of cholesterol in treatment group (120.5+39.9 mg/dl) was higher than control group (166.5+39.1 mg/dl) and the mean triglyceride level in treatment group (138.1+65.3 mg/dl) was higher than control group (91.7+44.2 mg/dl), which were both statistically significant (p<0.001). No significant difference was observed between HDL cholesterol in treatment and control groups (p<0.177). However, the mean LDL level was higher in treatment group (143.5+37.6 mg/dl) than that of control group (106.3+35.6 mg/dl) which shows a significant difference (p<0.001). No significant difference was observed between the mean plasma antioxidants in treatment and control groups (p>0.05). The study findings suggest the relationship between SD with total cholesterol and triglyceride levels and blood plasma LDL. However, there was no association between SD and plasma antioxidant and HDL levels.