جستجوی مقالات مرتبط با کلیدواژه "دیابت" در نشریات گروه "پزشکی"

Cardiomyopathy is one of the complications of diabetes that increases the risk of death in patients. The present study aimed to compare the effect of aerobic and resistance training on the inflammatory and metabolic sensors of heart tissue in male diabetic rats.

Twenty-two male rats with weight (179±22) gr were divided into four groups: healthy, diabetic sham, diabetic with aerobic training, and diabetic with resistance training. Moderate-intensity aerobic training by running on a treadmill and resistance training by climbing a ladder with certain weights were performed 6 weeks and 5 days a week. The amount of SIRT-1 and NF-κB protein was measured by the western blot method, and the ANOVA, Paired-Sample T-test, and covariance analysis statistical methods were used at the P≤0.05 level.

Reduction of blood sugar in the diabetic group with aerobic training from (377±131) to (249±81) mg/dL (P=0.036) and resistance training from (468±70) to (246±83) mg/dL was significant (P=0.040), and the effect of resistance training was greater (P=0.037). NF-κB protein had a significant decrease in aerobic training (1.18±0.007) and resistance training (1.17±0.04) compared to the diabetic sham group (1.88±0.09), (P≤0.001). The effect of both types of training on SIRT-1 protein was not significant.

Resistance training, like aerobic training, has a similar effect on reducing inflammation in the heart and has a better effect on reducing blood sugar. The effect of both types of physical activities on inflammation was more effective than the metabolic factor. Resistance training can be a suitable alternative to aerobic training to reduce blood sugar and inflammation caused by diabetes.

One of the most significant complications of type 2 diabetes is the disruption of glucose transport mechanisms in cell membranes, with GLUT4 and AS160 proteins playing crucial roles in this process. The aim of this study was to investigate the impact of aerobic exercise on GLUT4 and AS160 protein levels, as well as insulin resistance, in the EDL muscle of type 2 diabetic rats.

In this experimental study, 30 adult male rats were randomly assigned to three groups: healthy control, type 2 diabetes, and type 2 diabetes with aerobic exercise. Type 2 diabetes was induced through a high-fat diet combined with intraperitoneal injections of streptozotocin and nicotinamide. The aerobic training regimen consisted of five treadmill sessions per week for eight weeks. EDL muscle samples were collected 48 hours after the final training session.The levels of GLUT4 and AS160 proteins and insulin levels were measured using the ELISA method and insulin resistance was also calculated by HOMA-IR method.

The levels of GLUT4 and AS160 were significantly decreased in the diabetic group (P=0.001). Aerobic exercise significantly increased the levels of both GLUT4 and AS160 (P=0.01). AS160 levels in the control group were significantly higher than those in the diabetes + aerobic exercise group (P=0.001); however, there was no significant difference in GLUT4 levels between the control and diabetes + aerobic exercise groups (P=0.59). A significant positive correlation was observed between GLUT4 and AS160 (r=0.734, P=0.001), while significant negative correlations were found between both GLUT4 and AS160 with blood glucose levels (r=-0.751, P=0.001 and r=-0.955, P=0.001, respectively). Furthermore, insulin levels and insulin resistance in the diabetes + aerobic exercise group were significantly lower than those in the type 2 diabetes group (P=0.001).

Aerobic exercise alleviates hyperglycemia and enhances AS160 and GLUT4 protein levels in the EDL muscle. These findings suggest that aerobic exercise may help compensate for the impaired glucose transport mechanisms associated with type 2 diabetes in the EDL muscle of rats.

Gestational Diabetes Mellitus (GDM) is any degree of glucose intolerance with onset or first recognition during pregnancy. Regular exercise is important for a healthy pregnancy and can lower the risk of developing GDM. On the other hand, the crux of the matter is to find a bio predictor capable of signaling out women at risk of developing GDM as early as the very start of pregnancy. This study aimed to present the potential and significance of Spexin (SPX) in the pathogenesis of GDM.

Sixty female Wistar rats (weighting 220 ± 10g) were randomly assigned into six groups: control (Ctr) group, control+continuous aerobic training (Ctr+CON) group, control+intermittent aerobic training (Ctr+INT) group, gestational diabetes mellitus (GDM) group, GDM+continuous aerobic training (GDM+CON) group, GDM+intermittent aerobic training (GDM+INT) group. Exercise groups underwent treadmill exercise during pregnancy. Levels of insulin sensitivity and spexin were measured. A one-way ANOVA statistical test was used for statistical analysis.

Serum spexin concentration in the GDM group was significantly higher than Ctr; on the other hand, the spexin level in the GDM+CON and GDM+INT groups was considerably lower than in the GDM group. On the 20th day of gestation, the weight of the GDM group was significantly higher than that of the Ctr and training groups. The birth weight of offspring in the GDM group was significantly higher than that of the Ctr and Exc groups. Insulin sensitivity levels in the GDM+CON and GDM+INT groups were significantly lower than in the GDM group.

The results of this study demonstrate that both continuous and intermittent training were effective in improving GDM, but there was no statistically significant difference between the two training models. In addition, Changes in SPX levels seem to be influenced by the presence of GDM in pregnant women, with increased levels in those with GDM. It may be used as a potential factor to predict the development of GDM.

Considering the drug resistance of chemotherapy in diabetic patients and the prevalence of acute lymphoblastic leukemia in them, the present study aimed to investigate the effect of hyperglucose condition on the expression of DR5 and Caspase-8 genes in lymphoblastic cells (NALM-6) and its relationship to the cells' response to methotrexate.

In this in vitro study, NALM-6 cells were cultured in RPMI 1640 medium with 10% fetal bovine serum (FBS) containing antibiotics across four control groups: cells in the control group (C), cells treated with methotrexate (C+M), cells treated in an environment with high glucose concentration (G), and cells treated in an environment with high glucose concentration and methotrexate (G+M). The treated cells were subjected to hyperglucose conditions for 10 days in an environment with high glucose concentration. The survival rate of methotrexate-treated cells was evaluated by the MTT method, and then the relative expression of DR5 and Caspase-8 genes was measured by the RT-qPCR method. The statistical significance was defined as a P-value less than 0.05.

The M group had 50% survival compared to the control group, and the G+M group had 58% survival compared to the control group. The expression of the DR5 gene in the group G+M compared to the G group was not significantly different (P>0.05); however, the expression of the caspase-8 gene in the G group was significantly lower compared to the control group (P<0.01) and also lower in the G group compared to the treated cells (P<0.001).

The findings indicated that the survival rate of NALM-6 cells in high concentrations of glucose after treatment with methotrexate was higher than the same condition in the control group, which indicates the effect of glucose resistance on drug treatment.

Managing overweight and obesity is associated with lower risks of chronic diseases like diabetes. Digital health, particularly smartphones or m-health, effectively manages body weight. Technologies such as telemedicine services, mobile health (mHealth) or the use of mobile phones or portable digital devices in healthcare services and wearable devices can be used in this field. Therefore, this study was conducted to understand the impact of digital health technologies on weight management in diabetic patients.

The present study is a systematic review study that was initially searched using a systematic review of published studies in the field of digital health for weight management in diabetic patients from October 1401 to October 1402. Our study was conducted in two rigorous steps. Firstly, we performed a systematic review by searching for publications on Digital Health Solutions for Body Weight Management in Diabetic Patients until 12 October 2022. We meticulously combed through two comprehensive databases, PubMed and Web of Science, using a set of specific and relevant keywords. After a thorough screening and full-text assessment, we handpicked eight documents for this study. We cross-referenced with the companies' websites producing the identified applications to enrich our findings further.

In the initial search, 223 documents were identified and after screening and qualitative evaluation, eight documents were selected for this study. Our research uncovered a range of mHealth apps that have shown promise in weight management for diabetic patients. These apps have demonstrated potential efficacy, high acceptability, and favorable user experiences. Importantly, they have also improved diabetes management and quality of life for the users.

Our review of digital health solutions has not only illuminated their potential in weight management for diabetic patients but also opened up new avenues for a more personalized, engaging, and practical approach to this issue. As technology continues to advance, these interventions hold the potential to revolutionize diabetes self-management, significantly enhance the quality of life, and contribute to better health outcomes for individuals living with diabetes.

Hyperglycemia affects pathways involved in pulmonary arterial blood pressure. The aim of this study was to investigate the association between diabetes and pulmonary hypertension in patients with chronic respiratory disease referred to Bu Ali Hospital in Tehran.

In this descriptive-analytical study, 149 cases of patients with chronic respiratory disease in Tehran's Bu Ali Hospital from 1395 to 1401 were examined. Information was extracted from the files and recorded in the data collection form.

The data of 149 patients with mean age of 65 ± 8.6 years were analyzed. The prevalence of pulmonary hypertension and type 2 diabetes were 14.8% and 32.9%, respectively. No relationship between pulmonary hypertension and gender (p=0.34), smoking (p=0.64), type of diabetes medicine (p=0.70), age (p=0.97), FEV1/FVC (17 p = 0.05) and BMI (p = 0.06) was found. There was a significant relationship between pulmonary hypertension and diabetes (p<0.001), duration of diabetes (p=0.03), HbA1c (p<0.001) and FBS (p<0.001).

The prevalence of diabetes in patients with chronic respiratory disease with pulmonary hypertension is higher than in patients without pulmonary hypertension. More studies are needed to evaluate the impact of diabetes and hormones involved in blood sugar control in patients with chronic respiratory diseases with diabetes.

Gestational diabetes is a metabolic disorder in which pregnant women suffer from hyperglycemia, which can have severe consequences for the mother and fetus. Therefore, the present study was designed and implemented to determine the predictors of anxiety in mothers with gestational diabetes in Mashhad, Iran.

The current study is a cross-sectional analytical study of 200 pregnant women with gestational diabetes. A multi-stage and random sampling method was selected from Mashhad health centers. Questionnaires, including demographic information and a pregnancy anxiety scale, were sent online. Data were analyzed using One-way ANOVA, Independent T-test, Pearson Correlation, and Linear regression analysis.

The results showed that occupation (P < 0.001), education (P < 0.001), trimester of pregnancy (P < 0.001), number of deliveries (P = 0.022), unwanted pregnancy (P < 0.001), and insurance (P < 0.001) have a direct and significant relationship with the level of pregnancy anxiety. The highest correlation with different dimensions of pregnancy anxiety was related to insulin injection and the health dimension of the baby (r = 0.696). In the regression analysis, the most predictor related to the trimester of pregnancy variable, direct relationship(B standard = 0.678, P= 0.001) in the field of concern about physical changes and education, the most inverse relationship (B standard = -0. 382, P = 0.001) was in the field of childbirth anxiety.

Demographic factors such as occupation, education, and pregnancy status have a significant effect on pregnancy anxiety. Also, major concerns related to childbirth emphasize the need for targeted interventions in health care to reduce maternal anxiety.

Diabetes and the wounds caused by it are considered to be one of the most important health and treatment issues in the world, which impose a high economic burden on the society, therefore, effective measures to heal diabetic wounds are of great importance.

The aim of this study was determining the effect of Polyurethane contains silver particles dressing on the healing process in diabetic foot ulcers in patients admitted to Shahid Dr. Chamran Hospital.

This study was a randomized clinical trial that was conducted on patients with diabetic foot ulcers who referred to the wound clinic department of Shahid Dr. Chamran military Hospital in Tehran in 2021 -2022. A total of 48 eligible patients were selected with informed consent and randomly assigned to the intervention and control groups with block randomization. In the intervention group, polyurethane foam dressing containing silver particles was used for diabetic wounds, and in the control group, routin sterile dressing was used for dressing. The size, depth and degree of infection were checked on the first, seventh, fourteenth and twenty-second days after the start of dressing in both groups. Demographic information form and Bates-Jenson wound assessment checklist were used to collect data. Data were analyzed with SPSS version 21 software and statistical tests using repeated measures, Chi-square, Fisher and independent t -Test.

There was no significant difference in the evaluation process of the wound before the intervention in the two groups (P=0.418). However, there was no change after the intervention (P=0.02). Also the severity of the wound before the intervention was not significantly different in the two groups (P=0.231), but it changed after the intervention (P=0.049).

Polyurethane dressing containing silver particles was more effective on the healing process of diabetic wounds of patients than simple sterile dressing. It is recommended that nurses use the above dressing in addition to simple sterile dressings for faster treatment of diabetic foot wounds.

Management of chronic diseases, such as hypertension and diabetes, requires a comprehensive long-term care plan. Adherence to self-management behaviours is crucial in improving health outcomes and quality of life for individuals living with these conditions. The research highlighted in this review study aimed to explore the potential of mobile health technology in enhancing primary and secondary prevention of chronic diseases. By providing personalized interventions, mobile applications can play a significant role in supporting individuals in the self-management of their hypertension and diabetes, ultimately leading to better disease control and improved overall well-being.

The present study is a systematic review of research examining the impact of mobile application interventions on the self-management of hypertension and diabetes. The review analyzes studies published between July 2013 to March 2023, retrieved from the PubMed and Scopus international databases using keywords such as Mobile Health, mHealth, adherence, Hypertension, High Blood Pressure, and Diabetes.

A total of 1398 abstracts were found, of which 12 articles met the inclusion and exclusion criteria for this study. The research indicates that mobile health (mHealth) applications have significant potential to optimize healthcare processes and facilitate improved access to health information. These digital tools can combine various treatment methods with attractive, user-friendly solutions that allow patients to actively monitor a range of health indicators, such as diet, body weight, blood pressure, mood, and sleep patterns. By enabling this type of continuous self-monitoring, mHealth apps can empower individuals to take a more active role in managing their well-being. Additionally, these applications can facilitate greater collaboration between healthcare providers, patients, and their families, thereby enhancing the overall coordination and accessibility of care. As such, mHealth technologies can be effectively leveraged in conjunction with traditional medical services to improve health outcomes and expand access to critical health information.

The present study found a significant increase in mobile health app usage. To understand the real, long-term impact of this technology on health, further longitudinal studies are needed. Comprehensive research is crucial to guide the development of effective digital health interventions that can improve individual and population outcomes over time.

Diabetes is known to be linked with a high risk of liver stiffness in non-alcoholic fatty liver patients. Previous studies have faced challenges in examining the association between prediabetes and liver stiffness. This study aimed to compare liver fibrosis in diabetes and prediabetes patients.

This cross-sectional descriptive study was conducted on patients with diabetes and prediabetes who were referred to Imam Khomeini Hospital in Ahvaz from March 2022 to March 2023. The study aimed to clear the relationship between liver stiffness and age, gender, BMI, AST, ALT, ALKP, Bilirubin, and the type of treatment. The normality of quantitative variables was checked using the Kolmogorov-Smirnov test. The chi-square test examined two qualitative variables with more than two levels.

Out of the total participants, 53 people (63.9%) had diabetes, while 30 people (36.1%) had prediabetes. There was a significant difference between the mean severity of liver fibrosis in diabetic and pre-diabetic patients (P=0.014). The frequency of liver stiffness in all levels except in the group with mild or no fibrosis (F0-F1) was higher in diabetic than pre-diabetic patients. In both diabetes and prediabetes groups, there was no significant relationship between gender, age, BMI, ALT, and ALKP with liver fibrosis. However, there was a significant direct relationship between HbA1C% and liver fibrosis (P≥0.003) in both groups. In diabetic patients, a significant relationship between FBS and liver fibrosis was observed (P=0.001). In pre-diabetic patients, significant direct relationship was seen between the severity of liver fibrosis and AST levels (P=0.026).

Diabetic patients showed a higher severity of liver fibrosis compared to pre-diabetic patients. No statistically significant relationship was seen between liver fibrosis and age, sex, body mass index, ALT, and ALKP in both groups. Additionally, both diabetes and prediabetes groups showed significant relationship between liver fibrosis and HbA1C (P≥0.003). Prediabetes was also found to be associated with an elevated risk of liver fibrosis.

This study was carried out on camel milk consumption to improve risk factors of type 1 and 2 diabetes and metabolic syndrome. The purpose of this systematic review was to assess effects of camel milk on glycemic indices and blood lipid profiles in patients with metabolic syndrome and type-1 and type-2 diabetes.

To extract original English articles published until May 2023 without limiting the year of publication, Scopus and PubMed databases were searched using the following keywords of “metabolic syndrome” or “type 1 diabetes” or “type 2 diabetes” or “lipid profile” or “insulin” or “fasting blood glucose”  or “HbA1c” and “camel milk”.

From 73 studies, 11 studies were included in the present systematic review .Seven studies assessed fasting blood sugar levels and in three studies, fasting blood sugar levels decreased after consuming camel milk. Moreover, seven studies assessed levels of HbA1c and in four studies, levels of HbA1c decreased significantly. Six studies investigated doses of insulin. In five studies, levels of insulin dose in the camel milk consumption group significantly decreased, compared to the beginning of the study. Furthermore, eight studies assessed the blood levels and in most of these studies, blood profiles changed.

Results of the consumption of camel milk on glycemic indices and blood lipid profiles were contradictory. It is necessary to carry out clinical trial studies with longer times and larger sample sizes.

Adipogenesis is a dynamic process that leads to the phenotype of mature fat cells and plays a significant role in obesity and diabetes. The present study investigates the effect of Eight –Weeks of High-Intensity Interval Training (HIIT) and L -carnitine Consumption on the expression of BMP7 protein in visceral adipose tissue in diabetic rats.

In an experimental clinical-intervention study, 50  male Wistar rats were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplement and exercise (D + LC + T). The training program consisted of eight weeks, 5 sessions per week (6 to 12 2-minute sessions with an intensity of 85-90% of the maximum speed). The subjects received 30 mg/kg body weight L-carnitine through drinking water. Visceral fat was extracted and the expression level of BMP7 protein was assessed using Western Blotting. Data analysis was performed by one-way ANOVA and Tukey post hoc test at a significant level of (P< 0.05).

The results showed that the expression of BMP7, the adipogenesis stimulating protein, in (D + T) and (D + LC + T) groups increased significantly (P< 0.001).

According to the results, it seems that HIIT exercise alone and with L-carnitine Consumption is more effective in the expression of protein associated with adipogenesis expression in visceral fat. However, a clear statement requires further research in this area.

Health literacy is considered an important determinant of society's health, and high health literacy increases opportunities for empowerment in health-related decision-making. The present study aimed to determine the relationship between health literacy and the theory of planned behavior (TPB) constructs to conduct a diabetes test in at-risk individuals in Kurdistan province (Ghorveh City), Iran.

The present study was a cross-sectional descriptive research conducted in 2024. A total of 282 at-risk individuals eligible for inclusion in the study were selected to participate in the survey using a multi-stage random sampling method. Data collection tools included a demographic information form, a researcher-made questionnaire related to TPB constructs, and a health literacy questionnaire completed through an interview. Data were analyzed using the SPSS (version 23) software, descriptive tests (mean and standard deviation), and analytical tests (chi-square, Pearson correlation, and multiple regressions).

The mean and standard deviation related to the age of the participants was equal to 45.88±9.24. There was a relationship between gender, occupation, age, years of education, health literacy, monthly income, insurance coverage, and the ability to pay for testing to conduct a diabetes test (P≤0.05). Moreover, there was a significant positive correlation between the constructs of the TPB, health literacy, and the intention to undergo diabetes testing. The demographic variables, health literacy, and TPB constructs accounted for 74% of the variance in the intention to perform diabetes testing.

The demographic factors, risk factors, health literacy, and the TPB constructs predict the intention to conduct a diabetes test in at-risk individuals. Therefore, it seems necessary to pay attention to the mentioned variables in the design of educational interventions.

COVID-19 infection initially results in respiratory complications; however, it may be associated with a hypercoagulable state, leading to arterial and venous thromboembolism. Thus, this study aimed to investigate the frequency of thromboembolism in COVID-19 patients admitted to Shahid Rahimi Hospital in Khorramabad.

In this cross-sectional (analytical) study, all patients with COVID-19 were admitted to Shahid Rahimi Hospital in Khorramabad from October 2020 to the end of September 2021. Laboratory and clinical variables of patients with positive polymerase chain reaction tests were collected. The incidence of thromboembolism was investigated in patients with radiological reports, and then the data were analyzed using SPSS25 software. The significance level was considered at < 0.05.

Out of 3,612 patients with COVID-19, 19 had pulmonary thromboembolism. Diabetic patients accounted for 2.5%, patients with a history of hypertension accounted for 1.8%, and patients with a history of heart disease accounted for 1.5% of pulmonary thromboembolism cases. Patients with a smoking history constituted 0.5%, deceased patients represented 0.8%, and discharged patients also accounted for 0.5% of pulmonary thromboembolism cases. Patients who received at least one dose of the vaccine made up 0.4%, and patients with a previous COVID-19 infection accounted for 0.5% of pulmonary thromboembolism cases. There was a significant correlation between diabetes, hypertension, age, and a previous history of COVID-19 with the incidence of pulmonary thromboembolism (P<0.05).

Diabetes and high blood pressure increase the risk of pulmonary embolism in COVID-19. Therefore, those suffering from underlying diseases need more care regarding COVID-19.

In today's world, care and health in different dimensions for the elderly are important health goals. Considering the great importance of social and spiritual health and the existence of challenges in these topics, the present study aimed to determine the relationship between social and spiritual health in diabetic elderly in 2023.

The current research is cross-sectional (descriptive-analytical), and its statistical population involves all diabetic elderly people in Golestan province, Iran, in 2023. The samples included 199 elderly people who were selected based on the conditions of entry into the study and by multi-stage cluster random sampling method. The data collection tools in this study included questions related to demographic characteristics, Keyes's Social Well-Being Questionnaire (KSWBQ), and Paloutzian & Ellison's Spiritual Well-Being Questionnaire (SWBS). After explaining the objectives of the study and how to complete the questionnaire to the research units and assuring them regarding the confidentiality of the answers, the researcher, after obtaining written consent, asked the participants to complete the questionnaires. Finally, the data were collected from the completed questionnaires and analyzed using SPSS (version 26) software. A significant level of less than 0.05 was considered.

The results indicated that 54.3% of the participants were females and 45.7% were males. Most (35.4%) were between 65 and 70 years old, and 89.9% were married. The majority of the participants were housewives (43.4%) and retired (41.2%). In addition, 45.2% were consuming more than five medications, and 63.5% had at least two chronic diseases. Moreover, analytical results indicated that the total social health score increased significantly with improved spiritual health under flourishing, solidarity, and social cohesion scales (P<0.05). With increasing age and a higher number of children (P<0.05), as well as a lower number of medications consumed (P<0.05), individuals with chronic diseases (P<0.05) and those reporting decreased self-perceived health (P<0.05) exhibited better spiritual health. Furthermore, individuals who use medications 1-2 times (P<0.05) and have a duration of illness between 1 and 5 years (P<0.05) demonstrate higher levels of social health.

The result of the present study revealed a relationship between spiritual health and some subscales of social health in diabetic elderly people, and each of these cases is related to medical, clinical, and demographic characteristics.

Diabetes is one of the non-communicable diseases that cause many effects on the body. Today, the chosen lifestyle and daily behaviors of the individual, especially sports activities, are used a lot to reduce the complications caused by it. The purpose of this study was to evaluate the effect of eight weeks of combined exercises on the plasma levels of kynurenine and body composition of type 2 diabetic men.

Methods and Materials:

 In this research, subjects included 24 men with type 2 diabetes with an age range of 60.29 ± 4.00 (years), weight 87.37 ± 6.83 (kg), height 57.57 ± 0.11. 1 (m), body mass index (kg/m2) 36.12 ± 9.09, fat mass (percent) 28.77 ± 1.94, muscle mass (kg) 26.82 ± 1.66, average blood sugar Three months (A1C) 7.74 ± 0.41, fasting blood sugar (mg/dL) 163.79 ± 2.14, medical history (years) 3.92 ± 0.50, voluntarily They were selected and randomly divided into two groups, the experimental group (12 people) and the control group (12 people). The experimental group for eight weeks, three sessions of 60 to 80 minutes each week, combined exercises including resistance exercises (four exercises for the upper and lower muscles with an intensity of 60 to 70%, one maximum repetition) and aerobics (with an intensity of 60% of the maximum oxygen consumption for 15 minutes) and the control group had no training during this period. In order to measure research variables, blood sampling was done 48 hours before the start of the first training session and also 48 hours after the last training session while all subjects were fasting. ELISA method was used to measure kynurenine plasma levels. To analyze the data, the statistical test of correlated t-test, independent t-test and Shapiro-Wilk test was used to normalize the data at a significance level of 0.05, with SPSS version 22 software.

The results of the present study showed that eight weeks of combined exercises reduced the plasma levels of kynurenine. In addition, combined training led to a decrease in fat mass and body mass index and an increase in fat-free mass.

Based on the results of this research, it is suggested to use combined exercises to reduce the plasma levels of kynurenine and improve the body composition of type 2 diabetic men.

The objective of this study was to investigate the effect of resistance training on some apoptotic markers of kidney tissue with morphine withdrawal syndrome in diabetic rats. 

In this experimental study, 32 male Wistar rats were randomly divided into 4 groups of 8, including: diabetes, morphine diabetes, diabetes + resistance training, diabetes morphine + resistance training.  After implementing the diabetes induction protocol, the addicted groups received morphine orally for 21 days, and then the training groups participated in the resistance training protocol for 8 weeks. Then all the mice were killed and dissected and their kidney tissue was removed. ELISA kits were used to evaluate apoptotic factors.

Cytochrome-C variable results showed a significant decrease in the morphine diabetes (P=0.002) and diabetes + resistance training (P=0.001) and morphine diabetes + resistance training (P=0.001) groups compared to the diabetes group. The results of the caspase-8 variable also showed that the diabetes + resistance training group had a significant decrease compared to the diabetes group (P=0.004) and the morphine diabetes group (P=0.012).  Also, the reduction of caspase 3 variable results in the morphine diabetes group (P=0.001), diabetes + resistance training (P=0.001) and morphine diabetes + resistance training (P=0.002) was significant compared to the diabetes group.

Resistance training has reduced apoptotic indices in kidney tissue and can be a suitable treatment strategy for diabetes and withdrawal syndrome diabetes.

Diabetes mellitus is a spreading disease in the world. Despite the effective role of supportive resources in diabetes management, there is currently no documented plan for the use of these resources in diabetic patients. So the research team, while designing a support resource-based care program based on qualitative study and systematic review, conducted the present study with the aim of validating the program in people with type 2 diabetes mellitus using the Delphi method.

This is a methodological study conducted to validate the Delphi care program. Panel members included 15 experts in the field of diabetes, who were selected by the snowball method. The data collection tool was a structured questionnaire with 38 questions that were designed based on different parts of the care plan. The data was analyzed using SPSS software (version 18), and the percentage of agreement with the questionnaire dialects continued until a consensus was reached.

In the first round of Delphi, the preliminary draft of the care plan was drafted and amended based on the suggestions and corrective opinions of the participants. Then the contents of the questionnaire questions were prepared. In the second round of Delphi and the consensus on the dialects of the questionnaire, the percentage of agreement of the members of the expert panel based on the questionnaire questions was obtained at 93.5.

Given that the scientific and practical acceptability of the care program based on support resources, based on the questions raised in the present study, was "very high" and "high", it is recommended that this program be used to design and complete related programs at the national level.

Diabetes is a metabolic disorder characterized by high blood glucose levels and insulin resistance. Pioglitazone can lower insulin resistance and has anti-inflammatory properties. The aim of this work was to develop pioglitazone-loaded nanofibers and to evaluate their effect as a dermal implant device to lower blood glucose levels. The effect of pioglitazone-loaded nanofiber was investigated as a wound dressing in diabetic Wistar rats.

In this work, nanofibers were developed using the electrospinning method. The structure and characteristics of the fibers were evaluated using scanning electron microscopy and Fourier Transform Infrared Spectroscopy. The effect of nanofiber implants was evaluated on blood glucose levels , and their wound healing effect was investigated in diabetic wounds in a Wistar rat model.

The developed formulations did not show any effect in lowering blood glucose when used as an implant; however, they were able to accelerate the wound healing rate when used as a dressing in the wound model. This effect might be due to the anti-inflammatory properties of the drug. The developed wound dressing was able to accelerate the formation of the epidermis and dermis layers in the wound model.

Histological studies indicate that wounds treated with pioglitazone-loaded nanofibers exhibit an anti-inflammatory effect and therefore can increase the wound healing rate. These drug-loaded nanofibers enhanced the development of collagen and improved the formation of the epidermis and dermis while reducing the number of inflammatory cells. The developed drug delivery system was not able to significantly decrease blood glucose levels in the animal model. This effect may be due to the low drug loading capacity as well as its poor aqueous solubility.

Body mass index in patients with diabetes is influenced by health promoting behaviors, distress tolerance and eating behavior, and changes in them may cause changes in the condition of diabetic patients.

The purpose of this study was to compare the effectiveness of commitment and acceptance therapy and self-compassion therapy on distress tolerance and eating behavior in patients with type 2 diabetes.

The research method was semi-experimental with a pre-test-post-test-follow-up design with the control group and the statistical population of this research including all overweight people with a body mass index of 25-35 referring to the research laboratory of Tehran in the fall and winter of 2021, among them, 45 people were selected using available sampling method. They were randomly divided into two experimental and control groups. The pre-test, post-test, and follow-up research tools were the Distress Tolerance Scale by Simons & Gaher and the Three-Factor Eating Questionnaire by Cappelleri et al. (2009). After the 8 sessions of 90-minute acceptance and commitment-based therapy and the 8 sessions of 90-minute self-compassion therapy, research data were analyzed using variance analysis with repeated measurements.

The results showed no difference between the effectiveness of commitment and acceptance therapy and self-compassion therapy on distress tolerance and eating behavior in patients with type 2 diabetes (P<0.05).

The results of the present study showed that acceptance and commitment therapy and self-compassion therapy are effective treatments in reducing the psychological problems of overweight people, including eating behavior and distress intolerance.