جستجوی مقالات مرتبط با کلیدواژه "سالین هایپرتونیک" در نشریات گروه "پزشکی"

During craniotomy surgery, adequate intracranial pressure is a key factor in facilitating tumor removal surgery. So, it is essential to find a therapeutic approach to have proportional cranial pressure. Therefore, the purpose of this study was to compare the effect of thiopental sodium supplementation and hypertonic saline 5% alone or their combination on intracranial pressure changes and brain relaxation during craniotomy surgeries. This was a randomized, double-blind clinical trial study performed on 67 patients under craniotomy (22 patients in hypertonic saline, 23 in thiopental sodium, and 22 in hypertonic saline and thiopental sodium group). Patients were randomly assigned into three groups and the drugs were prescribed after anesthesia. Vital signs and intracranial pressure were recorded in patients. Chi-square and ANOVA tests were used to compare the data. In the group receiving hypertonic saline plus thiopental sodium, the rate of relaxation was the best with highest score of 3.86 ± 0.35 (P < 0.001), and surgeon satisfactory was more with the highest score of 3.86 ± 0.35) (P = 0.005). Moreover, in this group, the stability of hemodynamic symptoms was also observed (P < 0.050). Considering the high prevalence of cerebrospinal hypertension following craniotomy surgery to remove supratentorial brain tumor, hypertonic saline plus thiopental sodium is recommended to be prescribed for all patients to reduce the complications, improve therapeutic outcomes, and increase the satisfaction of the patient and the surgeon.

Increasing in intracranial pressure is a life-threatening condition during craniotomy surgery, which increases the incidence of complications and mortality in patients. Therefore, it is necessary to find a way to cure this complication. The purpose of this study was to evaluate the effect of adding furosemide to hypertonic saline 5% on intracranial pressure changes in patients with craniotomy surgery for resection of supratentorial tumors.
This study was performed on 65 candidate for craniotomy surgery (33 patients in the intervention group and 32 in the control group). Patients were randomly divided into two groups; the intervention group received 5 ml/kg saline hypertonic 5% plus 0.05 cc/kg furosemide, and the control group received 5 ml/kg saline hypertonic 5% plus 0.05 cc/kg distilled water. Vital signs and intracranial pressure were recorded in patients.
Findings: The relaxation after cranial openings in the intervention group was significantly lower (1.66 versus 2.37) (P = 0.001), and also relaxation before the opening of the dura (1.33 versus 1.81) (P = 0.009). However, there was no difference in the hemodynamic parameters and the length of stay in the hospital (P > 0.050 for all).
Adding furosemide to hypertonic saline 5% improves and decreases intracranial pressure in patients with craniotomy surgery for resection of supratentorial tumors.

Increased intracranial pressure (ICP) can be life-threatening and is associated with poor prognosis. In these patients, mortality rate and life expectancy would increase by reducing the intracranial pressure. Finding appropriate way to reduce pressure without specific changes in blood electrolytes and blood pressure is essential. This study aimed to evaluate the effect of rehydration with hypertonic saline 5% on intraoperative complications and prognosis in patients with high intracranial pressure.
This study was performed on 90 patients with high intracranial pressure undergone surgery. After skin incision, hypertonic saline 5% was injected intravenously. Electrolytes and vital signs of patients at baseline and at 24 and 48 hours after the surgery were compared. The data were analyzed using ANOVA with repeated measures test.
Findings: 54 patients (60%) were men and 36 (40%) were women, with the mean age of 48.1 ± 9.8 years. Administration of hypertonic saline significantly increased sodium level (137.5 to 144.9 mmol/l), potassium level (3.8 to 4.96 mmol/l), the amount of output (1.43 to 3.94 l), systolic blood pressure (104.6 to 127.32 mmHg), diastolic blood pressure (61.58 to 85.13 mmHg) and anion gap (9.34 to 18.8) (P This study showed that the use of hypertonic saline 5% serum in patients with high intracranial pressure who need surgery, improve the electrolyte and vital signs, especially blood pressure, which increases the quality of treatment and consequently reduces mortality rate of the patients.

In this study، we compared the effects of hypertonic saline (HTS) 3. 2% and mannitol 20% on brain relaxation during brain tumor surgery. This prospective، randomized study included patients who were selected for elective craniotomy for brain tumors. Patients received either 1 g/kg of HTS 3. 2% (HTS group; n = 20) or 1 g/kg of mannitol 20% infusion (M group، n = 20) for 10 minutes at the start of scalp incision. Carbon dioxide partial pressure (PCO2) in arterial blood was maintained at 30-35 mmHg. Brain relaxation was rated as 0-3 by a surgeon. Surgeons assessed the condition of the brain as tight، appropriate، or soft immediately after opening the dura. Data was collected using a checklist and then analyzed by chi-square test with SPSS16. The mean age of the HTS and M groups was 48. 9 ± 10. 8 and 47. 4 ± 12. 1، respectively (P = 0. 670). There was not a significant difference between the American Society of Anesthesiologists (ASA) scores of the two groups (P = 0. 430). In the HTS group، 60. 0% of patients were in class II of brain relaxation conditions and 40. 0% were in class III. In the M group، 42. 1%، 52. 6%، and 5. 3% were in class I-III of brain relaxation conditions، respectively (P = 0. 043). Intracranial pressure (ICP) 20 minutes after the operation was lower in the HTS group compared to the M group (P = 0. 001). However، ICP at the 30th and 40th minutes was not significantly different between the two groups. Our results suggest that HTS provided better brain relaxation than did mannitol during elective brain tumor surgery. HTS is also cheaper than mannitol. HTS can increase cardiac output، accelerate resuscitation، and decrease inflammation and ICP.