جستجوی مقالات مرتبط با کلیدواژه "سلول های پیش ساز الیگودندروسیت" در نشریات گروه "پزشکی"

Demyelination in central nervous system is usually followed by remyelination; however, chronic lesions with subsequent functional impairment result from the eventual failure of remyelination process, as seen in multiple sclerosis. Remyelination is the process through which oligodendrocyte-progenitor cells (OPCs) restore new myelin sheathes around demyelinated axons. This study aimed to investigate the effect of A1 receptor agonist, N6-cyclohexyladenosine (CHA), on the demyelination and remyelination processes in rat optic chiasm following lysophosphatidylcholine (LPC)-induced demylination. In this experimental study, LPC was injected into the optic chiasm of three groups of rats (n=6). Control group received aCSF on different days following LPC injection. Two groups of animals received CHA on days 0-14 or 14-28 post-lesion. Demyelination and remyelination levels were evaluated by recording visual evoked potential (VEP) from the scalp. The highest level of demyelination was occurred on day 7 post-lesion LPC injection and gradually reduced during the days 7-28. The P-wave latency was significantly increased on day 7 and then partially restored during the days 7-28 post-lesion. CHA administration during the days 0-14 attenuated demyelination process. In addition, CHA administration in remyelination phase (days 14-28) was able to potentiate the endogenous myelin repair. Injection of CHA could prevent the lysolecithin-induced variations in VEP. The effects of CHA may be mediated through increment of OPCs proliferation and their differentiation into myelinating oligodendrocytes.