جستجوی مقالات مرتبط با کلیدواژه « سوء هاضمه عملکردی » در نشریات گروه « پزشکی »

Functional Dyspepsia (FD) is the most frequent disorder of the upper gastrointestinal tract. Functional dyspepsia is a biosocial problem. Although the disease does not lead to death, due to frequent clinical manifestations, the necessity to visit a physician, receiving medical care, and absence from work, significantly affect the quality of life in patients. Despite the extant empirical evidence to support the impact of psychological factors on FD, data on available psychological interventions are scarce. Thus, this study aimed to compare the effects of Mindfulness–Based Cognitive Therapy (MBCT) and Cognitive–Behavioral Therapy (CBT) on Emotion Regulation (ER) and symptoms in patients with FD.

This was a quasi–experimental study with a pretest–posttest–follow–up design. This study was conducted in 2017 in Mashhad City, Iran. The statistical population consisted of all patients referring to the Gastroenterology Clinic of the Ghaem Hospital who received a definitive diagnosis of FD by gastroenterologists after the laboratory tests and endoscopic examination. The study sample consisted of 30 patients who were selected by convenience sampling method according to the inclusion criteria; they were randomly divided into two equal experimental groups. The inclusion criteria of the study were the age range of 18–55 years, a definitive diagnosis of FD by a gastroenterologist, laboratory tests and endoscopic examination, no diseases, such as cancer and gastric ulcers, treating Helicobacter pylori infection, and Helicobacter pylori eradication therapy, literacy to complete the questionnaire, consent to participate in the research, and no other serious biopsychological illnesses. The exclusion criteria included generating other serious biopsychological conditions, and no consent to participate in the research. The research patients were randomly placed into the experimental groups of MBCT and CBT. MBCT and CBT were administered in eight 120–min weekly sessions. CBT and MBCT were performed as per Beck’s package (2001) and Segal et al.’s package (2013), respectively. The Cognitive Emotion Regulation Questionnaire (Garnefski et al., 2001) and the Nepean Dyspepsia Index (Talley et al., 1999) were employed to evaluate FD symptoms in pretest, posttest, and follow–up steps. The follow–up stage was performed 2 months after the posttest stage. The obtained data were analyzed using repeated–measures Analysis of Variance (ANOVA) and Bonferroni post hoc test in SPSS at a significance level of 0.05.

The obtained results suggested that the intragroup factor (time) was significant for FD and ER (p<0.001). Additionally, the intergroup factor and the time*group interaction were significant for FD and ER (positive & negative ER strategies) (p<0.001). In the MBCT group, the mean scores of FD significantly decreased from 56.66 in the pretest to 46.53 and 48.06 in the posttest and follow–up, respectively. However, in the CBT group, a smaller decrease was observed. In the MBCT group, the mean scores of positive ER strategies significantly increased from 46.13 in the pretest to 74.40 and 67.40 in the posttest and follow–up, respectively. However, in the CBT group, this increase was less. In the MBCT group, the scores of negative ER strategies significantly decreased from 50.06 in the pretest to 37.86 and 41.46 in the posttest and follow–up, respectively. However, in the CBT group, a smaller decrease was observed. There was a significant difference in the mean values of FD and ER between the pretest, posttest, and follow–up stages (p<0.001). Additionally, a significant difference was observed between the posttest and follow–up stages in the mentioned variables, indicating that the effects of the intervention were not permanent in the follow–up stage (p<0.001).

According to the present study data, MBCT was more effective than CBT in decreasing FD symptoms and improving ER in patients with FD.

Dyspepsia is a common complaint. Many reasons can cause dyspepsia such as gastrointestinal disorders or drugs. Almost always, the disease is called Functional Dyspepsia (FD) in modern medicine, because no structural or organic disorder accompany with it. This study was designed to investigate pathophysiological reasons of dyspepsia in Persian Medicine.

 This study was done by searching and evaluating valid books of 10th to 18th centuries. At first, chapters and paragraphs about dyspepsia were reviewed. Then, comparing Persian medicine content with modern medicine literature was done. Keywords of digestion and indigestion were used to search the chapters.

Causes of dyspepsia in Persian medicine are classified into internal and external causes which are in concordance with modern medicine classification. Delayed gastric motility, accelerating, impulsive and vibratory forms are pathophysiological types of dyspepsia in Persian medicine.

All dyspepsia causes mentioned in Persian medicine books are also confirmed by findings of modern medicine. This indicates the vast knowledge and the comprehensive consideration devoted to all aspects of human health by Persian medicine practitioners. Persian medicine considers organic, dietary, and psychological reasons as causes for dyspepsia

Functional Dyspepsia (FD) is the most common disorder of the upper gastrointestinal tract. FD is characterized by chronic or recurrent gastrointestinal symptoms in the absence of any organic or metabolic diseases, i.e., likely to explain them. Although FD does not lead to death, it significantly reduces a patientchr('39')s quality of life due to frequent clinical presentations, repeated medical visits, requiring healthcare services, and absenteeism from social settings. FD also imposes high costs on the healthcare system. Despite the existence of extensive empirical evidence to support the impact of psychological factors on FD, data on this issue are scarce. Thus, the current study aimed to compare neuroticism, Sensory Processing Sensitivity (SPS), Behavioral Inhibition (BI), and Emotion Regulation (ER) between patients with FD and a healthy group.

This comparative study was conducted in the summer and autumn of 2017 in Mashhad City, Iran. The statistical population of the study consisted of all patients who were referred to the gastroenterology clinic of the Ghaem Hospital where FD was definitively diagnosed by a gastroenterologist following laboratory tests data and endoscopic examination. The research sample consisted of 60 patients with FD who were selected using the convenience sampling method as well as 60 healthy adults who were matched for age, gender, and education with the test group. The inclusion criteria for the patient group of the study were as follows: receiving a definitive diagnosis of FD by a gastroenterologist after obtaining the laboratory tests results and conducting endoscopic examinations; the lack of organic diseases, like cancer and any gastric ulcers; a treatment history of helicobacter pylori infection and helicobacter pylori eradication therapy; literacy and awareness to complete the questionnaires; voluntary agreement to participate in the research; being adults aged 18–60 years; the lack of other serious physical illnesses, and the absence of major psychiatric disorders (as per the information obtained from the patient.( For the control group, the inclusion criteria included no FD, the absence of other serious physical illnesses, and no major psychiatric disorders )as per the data obtained from the participant) .In both research groups, the study participants completed the NEO–Five Factor Inventory (NEO–FFI) (Costa & McCrae, 1992), the Highly Sensitive Person Scale (HSPS; Aron & Aron, 1997), the Behavioral Activation And Inhibition Systems Scales (BAISS; Carver & White, 1994), and the Difficulties in Emotion Regulation Scale (DERS; Gratz & Roemer 2004). The collected data were analyzed using SPSS by Multivariate Analysis of Variance (MANOVA) and Independent Samples –test at the significance level of 0.05.

The current research findings indicated a significant difference in neuroticism between the study groups (p<0.001). The experimental group’s neuroticism scores were significantly higher than those of the controls. Comparing the scores of HSPS (p<0.001) and its subscales, including the ease of excitation (p<0.001), aesthetic sensitivity (p<0.001), and low sensory threshold (p<0.001) suggested a significant difference between the study groups (p<0.001). There was a significant difference between the healthy and patient groups in ER (p<0.001) and all of its dimensions, including the non–acceptance of emotional responses (p<0.001), difficulties engaging in goal–directed behaviors (p<0.001), impulse control problems (p<0.001), the lack of emotional awareness (p<0.001), limited access to ER strategies (p<0.001), and the lack of emotional clarity (p=0.014). The results of comparing the research groups concerning BI also revealed a significant difference (p<0.001), where the experimental group’s mean score was significantly higher than that of the controls.

The present study results indicated that high neuroticism, SPS, and BI, as well as emotion dysregulation, can be psychological characteristics involved in FD. Identifying these factors and applying appropriate psychological techniques along with medical interventions can facilitate the process of treating this condition.

Functional dyspepsia is a chronic disorder of the upper gastrointestinal tract that anatomical or biochemical abnormalities do not explain it. The purpose of this study was to assess the mediating role of stress, anxiety, and depression in the relationship between personality type D and functional dyspepsia.
This research is a correlation research. Accordingly,224 male and female dyspepsia patients were selected by available sampling method and according to the criteria of entry. Stress, anxiety and depression in patients evaluated by depression, anxiety, stress (DASS-21), personality type evaluated by Type-D (DS-14) and after primary diagnosis of gastroenterologist severity of functional dyspepsia evaluated by Gastrointestinal Symptoms Questionnaire (GRRS). In addition, data analysis was performed using Smart PLS software.
Findings: The findings of the study showed that D personality type directly affects the severity of functional dyspepsia (effect 41%), plus personality type D by mediating depression (31%) and anxiety (21%) on the severity of indigestion has a confidence level of 95%. However, because of the lack of path coefficient between the variables of stress and functional dyspepsia (T-value 96/1), the indirect effect of the D-type variable on the severity of functional dyspepsia was not confirmed with the mediation of stress.
The findings of this study indicate the importance of the role of psychological factors personality type D, anxiety and depression in functional dyspepsia.

Although lifestyle-related factors have separately been examined in relation to functional gastrointestinal disorders (FGIDs), there is no epidemiologic data on the combined association of lifestyle factors with these conditions. We aimed to examine how combinations of several lifestyle factors were associated with functional dyspepsia (FD), its symptoms and gastro-esophageal reflux disease (GERD) in a large group of Iranian adults.
This descriptive -analytic study was conducted on 3363 Iranian adults (19-70 yr), whom were working in 50 health centers across Isfahan province in Iran during 2012. We used easy non-random sampling to select participants. The “healthy lifestyle score” for each participant was calculated by summing up the binary score given for five lifestyle factors, including dietary habits, dietary intakes, psychological distress, smoking and physical activity. A dish-based 106-item semi-quantitative validated food frequency questionnaire, General Practice Physical Activity Questionnaire, General Health Questionnaire and other pre-tested questionnaires were used to assess the components of healthy lifestyle score. A validated Persian version of ROME III questionnaire was used, to assess functional gastrointestinal disorders.
The prevalence of FD and GERD among study participants was 14.5 and 23.6%, respectively. After adjustment for potential confounders, we found that individuals with the highest score of healthy lifestyle had 79 and 74% lower odds of FD (95% CI: 0.05-0.92, OR: 0.21, P=0.03) and GERD (95% CI: 0.09-0.69, OR: 0.26, P=0.01), respectively, compared with those with the lowest score. They were also less likely to have early satiation (95% CI: 0.11-0.73, OR: 0.28, P=0.001), postprandial fullness (95% CI: 0.09-0.50, OR: 0.22, P This study showed that adherence to a healthy lifestyle was associated with lower odds of GERD, FD and its symptoms in this group of Iranian adults. Individual lifestyle-related factors were also associated with these conditions.

The aim of this study was to translate and evaluate the validity and reliability of the Nepean Dyspepsia Index (NDI)¡ as a disease-specific quality of life scale in patients with functional dyspepsia.
Forward-backward translation was done. 80 patients with dyspepsia from the outpatient department of Imam Reza Hospital were assessed. Data were analyzed using SPSS software version 20 and face validity¡ content validity (CVR)(pls spell out)¡ construct validity (Spearman''s rrho)¡ and reliability (test-retest and Cronbach''s Alpha) were evaluated.
CVR was between 0.80-1¡ which demonstrated good content validity. Test-retest reliability was good with correlation coefficient of 0.89 and intraclass correlation coefficient of 0.96. Internal consistency revealed α value of 0.93¡ which was well above the agreeable value of 0.70. These both indicate a good reliability. Spearman''s correlation coefficient was 0.48. between all NDI items and subscales which indicates moderate to good construct validity.(it seems that this sentence is not complete because in this format it is meaningless)
This study demonstrates that the Persian translation of SF-NDI (pls spell out the highlighted part) is a valid and reliable instrument to measure health related quality of life (HRQoL) in Iranian patients with dyspepsia. It also shows that HRQoL is significantly higher in patients with high school diploma or higher educational levels.

Functional dyspepsia is considered one of the most common digestive diseases with tremendous cost and time expenditures for patients and health systems. An increase in the numbers of inflammatory cells such as mast cells and eosinophils are reported in the gastrointestinal mucosa of these patients. This study aims to determine the effects of histaminic receptor blockage on patients'' clinical symptoms and mast cell counts of gastrointestinal mucosa. This study evaluated the effects of combined cetirizine and ranitidine on patients with proton pump inhibitor resistant functional dyspepsia in terms of clinical symptoms and mast cell counts in the gastric mucosa. This study enrolled 31 patients. The patients declared the intensity of their symptoms as severe (in12 patients) and very severe (in 19 patients) which significantly decreased after treatment. Three patients expressed dissatisfaction with the treatment. The mean mast cell count before treatment was 47. 25 ± 29. 81 and after treatment it was 8. 74 ± 10. 63، which was an 80. 79±19. 15% reduction (p<0. 001). Postprandial distress syndrome was present in 25 (80. 6%) patients and 13 (41. 9%) had epigastric pain syndrome. Patients reported adverse events following treatment that included drowsiness (n=7)، overeating (n=1)، lethargy (n=1) and dry mouth (n=1). Combined treatment with cetirizine and ranitidine in patients with functional dyspepsia showed a significant reduction in the severity and number of mast cells in gastric mucosa and led to a high rate of satisfaction among patients.

Diet can be effective both in incidence and reducing symptoms of upper gastrointestinal disorder (UGIDs) especially dyspepsia and gastro-esophageal reflux. Dairy products are the food group may be related to gastrointestinal disorders. This project was a cross sectional study done under the name of SEPAHAN Project on employees of Isfahan university of medical sciences. Data was conducted in two phases. Nutritional data were collected in phase one using FFQ and data of gastrointestinal dysfunctions were collected in phase two through ROME III standard questionnaire. Subjects with completed data in both phases were 4763. Individuals in highest quintile of dairy intake (DPI) had 26% less risk for developing gastro-esophageal reflux, compared to those in the lowest quintile. An inverse association between DPI and UGID and its components was also found. There is an inverse association between DPI and UGID. Subjects in the highest quintile of DPI have lower prevalence of gastro-esophageal Reflux and functional Dyspepsia and its components, compared to those in lowest quintile.

Functional dyspepsia (FD) is a heterogeneous disorder of yet unknown etiology which causes a significant reduction in the quality of life. In this study, we compared the effect of buspirone as an agonist of serotonin 5HT1A receptor with amitriptyline and placebo on improving the symptoms and quality of life in patients with functional dyspepsia.

This study was a double-blinded, randomized controlled clinical trial. Using a sequential sampling, patients with the diagnostic criteria of Rome 2 and normal gastrointestinal findings were selected. The subjects were randomly divided into three therapeutic groups receiving amitriptyline, buspirone, and placebo. We used Nepean Dyspepsia Inde (NDI) to evaluate the quality of life before and after the treatment.

The mean age of subjects was 35.38±12.94 years. Symptom and quality of life scores of the three groups were equal at the beginning but at the end of treatment, these scores were different. Buspirone was more effective than both amitriptyline and placebo in reducing the symptom of early satiety. Buspirone showed a better improvement in quality of life compared to placebo. Both Buspirone and amitriptyline were more effective than placebo in decreasing the symptom of epigastric pain.

Our study confirmed the positive effect of buspirone on the quality of life and symptoms (like early satiety and abdominal pain) in patients with functional dyspepsia. Since the mechanism of action of buspirone and also the pathophysiology of functional dyspepsia are still unknown, further studies are necessary to clarify every aspect of the disease and therapeutic effects of various treatments on it.