جستجوی مقالات مرتبط با کلیدواژه "ظرفیت آنتی اکسیدانی تام" در نشریات گروه "پزشکی"

Diabetes along with morphine causes many metabolic damages in the testicles by causing oxidative stress. This study aimed to reduce the oxidative effects caused by diabetes and morphine on the fertility quality of men with the help of increasing moderate intensity aerobic exercise.

32 male Wistar rats were used in this experimental study. Mice were randomly divided into 4 groups of 8: diabetes control (D), morphine diabetes (D. M), diabetes + endurance training (D+ ET), diabetes + morphine endurance training (D. M+ ET). Then induction of diabetes and morphine was done. The training groups performed 8 weeks of endurance training protocol. At the end of the study, all mice were killed and their testis tissue was isolated. The oxidant and antioxidant indices of this study were measured. Data were analyzed by SPSS software version 16 using one-way ANOVA at a significant level of 0.05.

The results showed that the concentration of MDA in the diabetes group had a significant increase compared to other groups (P=0.001). However, increasing endurance training caused a significant decrease in the concentration of MDA (P=0. 001) and a significant increase in the amount of TAC, GPX and SOD (P=0. 001) in other groups compared to the diabetes group.

The present research showed that increasing endurance training with moderate intensity caused a decrease in the oxidant index and an increase in the antioxidant index in the testicular tissue of diabetic rats with withdrawal syndrome. And this shows the reduction of infertility complications in mice.

Oxidative stress is an important factor in the development of memory and learning disorder which can cause neuronal damage in the hippocampus. Alpha-pinene is a polyphenolic compound from the terpene family that has shown important anti-inflammatory, anti-anxiety, antioxidant and neuroprotective effects in the central nervous system and can affect memory. The aim of the present study was to investigate the effect of alpha-pinene on the improvement of working and spatial memory in rats. 

In this study, 24 male rats were randomly divided into 3 groups: control and 2 alpha-pinene groups (5 and 10 mg/kg IP) for 3 weeks. Spatial and working memories were assessed by Morris water maze and Y maze, respectively. Then, malondialdehyde level and total antioxidant capacity in hippocampal tissue were measured. Data were analyzed using one-way analysis of variance and Tukey's post hoc test.

The percentage of alternation in the Y maze increased in the group which had received 10 mg/kg alpha-pinene group compared to those in the control group and the group which had received 5 mg/kg alpha-pinene. The time spent in the target area at the dose of 10 mg/kg of alpha-pinene showed a significant increase compared to that in the control group, but there was no significant difference among the groups in terms of the time to reach the target platform. Alpha-pinene at the dose of 10 mg/kg decreased the level of malondialdehyde in hippocampal tissue compared to the control group, but no significant difference was observed between the groups in terms of total antioxidant capacity.

Alpha-pinene increased spatial and working memory performance in rats. One of the possible mechanisms of memory improvement in the present study could be due to the reduction of malondialdehyde in the hippocampal tissue, as one of the important indicators of oxidative stress in the central nervous system.

One of the important goals of therapeutic interventions is to control obesity and vitamin D deficiency, which are associated with the occurrence of cardiovascular disease, metabolic disorders and increased homocysteine. In this study, the effect of high-intensity interval resistance training (HIIRT) and vitamin D on homocysteine and total antioxidant capacity (TAC) ​​levels in overweight women with vitamin D deficiency was investigated.

In this clinical trial study, overweight women with vitamin D deficiency were investigated. The subjects were randomly divided into four groups of 13 (control, exercise, vitamin D and exercise+vitamin D). The exercise groups performed HIIRT with an intensity of 80% of one maximum repetition, and the vitamin D groups consumed vitamin D once a week. The collected data were analyzed using one-way analysis of variance and paired t-tests.

After 8 weeks of research interventions, homocysteine level decreased and TAC significantly increased in the experimental groups (P<0.001). In addition, combined intervention was associated with more changes in homocysteine and TAC levels compared to HIIRT and vitamin D intervention (P<0.001), but HIIRT and vitamin D had a similar effect on the changes of these variables (P>0.05).

It seems that part of the optimal effects of HIIRT and vitamin D consumption in the health development of overweight women with vitamin D deficiency can be induced by increasing TAC and decreasing homocysteine.

 Exercises and consumption of plant-based supplements are essential to prevent and control diseases. The present study aimed to investigate the effect of a four-week home workout plan and pomegranate supplementation on oxidative stress in overweight and obese postmenopausal women.

 The present single-blind, quasi-experimental, and practical study was conducted on 60 overweight and obese women between 45 to 65 years with a body mass index over 25 (kg/m2) who were randomly divided into four groups. After participant dropout, 56 women were divided into four groups. The first group (n=15) took pomegranate supplements and had exercise, the second group (n=13) took the placebo and had exercise, the third group (n=14) was given the pomegranate supplement and the fourth group (n=14) was given the placebo. The intervention and placebo groups took a 225 mg capsule of pomegranate supplementation and placebo daily for four weeks, respectively. Resistance training was performed in 28 90-min training sessions for four weeks at home due to the Covid-19 pandemic.

 The results of the present study indicated that exercise and supplementation significantly increase total antioxidant capacity, and decrease Malondialdehyde (MDA) (P<0/05); however, no significant effect was observed in the other groups. One-way ANOVA demonstrated that four weeks of training and supplementation significantly reduce the concentration of MDA compared to the control group (P<0.05). However, no significant difference was observed among the four groups in the total antioxidant capacity.

 Pomegranate supplementation together with a home workout plan can possibly reduce oxidative stress and prevent difficulties related to obesity.

The aim of this study was to evaluate the effect of Sprint Interval Training (SIT) on the plasma liver enzymes, liver tissue total-antioxidant-capacity (TAC) and Malondialdehyde (MDA) levels in male rats.

In an experimental trial, 16 male rats were randomly divided into two groups: control (CO,n=8) and exercise (EX,n=8). The rats after the period of adaptation to the environment and familiarization with exercise were trained 3 sessions per week for 8 weeks. Finally, after anesthesia and direct blood sampling from the heart, serum was extracted for liver enzymes and liver tissue was removed to assess tissue TAC and MDA. Independent t-test was used to analyze the data at the alpha level of 0.05 in SPSS version 22.

Statistical analysis of the data showed a significantly higher liver tissue TAC in the EX group compared to the CO group (P=0.01); but no significant intergroup difference was observed related to liver tissue MDA (P=0.24). There was no significant difference between the groups in the ALT (P=0.26) and GGT (P=0.44) level; but the AST (P=0.01) and ALP (P=0.001) level in EX group was significantly lower than CO group.

The results showed that SIT increases the antioxidant capacity and induces desirable changes in the liver enzymes levels and this training protocol can have a beneficial effect on the health status of the liver.

It has been proposed that regular exercise training is effective methods to reduce the levels of oxidative stress and its disorders. Therefore, this study was performed aimed to evaluate the changes of some total antioxidant capacity and lipid peroxidation markers following the combined with high intensity interval training in sedentary postmenopausal women.

This semi-experimental study was performed  in 2020 on 45 sedentary menopause women  in Bonab city. The subjects were randomly assigned to 3 groups: high-intensity interval training, combined exercise training and control. Exercise training programs were done in 3 nonconsecutive days for twelve week. Blood samples were collected 48 hours before and after exercise training and the level of malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. Data were analyzed by SPSS software (version 24) and correlated t-test and Covariance of analysis (ANCOVA) test. P<0.05 was considered statistically significant.

There were no differences between three groups in the physical physiological indices at the beginning of the study (p>0.05). The twelve week of both type of exercise training methods significantly decreased the MDA and significantly increased the TAC levels in sedentary menopause women  (p<0.05). While, there were no significant differences in these indicators during the study period in the control group. However, there were no significant difference between two exercise training methods (p>0.05). Moreover, significant correlation was observed between the changes of this markers with the changes in some of body composition indices in training groups (p<0.05).

Performing 12 weeks of combined and high intensity interval training can lead to increase of total antioxidant capacity and decrease lipid peroxidation indicators, therefore, it can be recommend these exercises training methods for postmenopausal women to improve oxidative stress.

Drug use induces inflammation and oxidative stress. The aim of the present study was to determine The effect of eight weeks of Pilates training on total antioxidant capacity and C-reactive protein in the blood in men addicted to methamphetamine who are quitting

The present study was a quasi-experimental study and the study population was addicted men who were leaving, 44 of whom participated in the study by simple random sampling. With at least three months in the addiction treatment camp, they were selected and divided into two groups, training and control. Pilates exercise was performed for 8 weeks, three sessions per week and each session for 60 minutes. Blood samples were taken from the brachial vein in pre- and post-test conditions. Blood levels of total antioxidant capacity and C-reactive protein were measured using laboratory kits. Data were analyzed using SPSS. 20.

Serum CRP levels in the control group did not change significantly (P=0.638) but in the exercise group was associated with a significant decrease (P= 0.039). Serum levels of total antioxidant capacity in the control group after eight weeks without significant change (P=0.288) but in the exercise group after eight weeks of intervention had a significant increase (P= 0.05).

Pilates caused reduce inflammation and decreased antioxidant capacity in addict persons. It is recommended that this type of exercise be used to strengthen the immune system of addicts.

The use of a single sauna for decreasing weight quickly has a significantly negative impact on the health. The present study aimed to investigate the effect of Saffron aqueous extracts on maximal oxygen uptake, serum lipid peroxidation and total antioxidant capacity of young men athlete following a single Sauna leads to a 4 percent body weight loss.

In a semi-experimental study twenty young athletic men were randomly divided into two equal groups of 1- control 2- supplement. Subjects in supplement group consumed 5 mg /kg/day of saffron for 4 days, whiles other group received the same amount of placebo (lactose). After four days of supplementation all subjects lost 4% of their body weight by dehydration in dry sauna. Serum total antioxidant capacity and malondialdehyde levels were measured in three stages, (baseline, and 4h before and immediately after sauna) and vo2 max was measured in two stages (1week before and immediately after sauna).

The mean age, weight, and body fat were 22.60±0.98 years, 76.07±5.11 kg, and 18.06±1.64 percent, respectively. The vo2 max in the two groups after sauna significantly decreased (p=0/001). As well as total antioxidant capacity and malondialdehyde levels in the only control group after sauna significantly decreased and increased respectively (p=0/001).

It can be concluded that the use of saffron extract improved levels of serum total antioxidant capacity, and thereby it significantly prevented the increase of in serum malondialdehyde after sauna. However the uses of saffron extract no significant effect on prevented the decrease in vo2 max after sauna.