جستجوی مقالات مرتبط با کلیدواژه « عامل رشد عصبی » در نشریات گروه « پزشکی »

Brain ischemia causes irreversible structural and functional damages to specific parts of brain particularly the hippocampus. There are evidences that show exercise training may decrease the damages inflected on brain. The purpose of this research was to examine the effect of exercise training on nerve growth factor (NGF) in hippocampus CA1 region following cerebral ischemia stroke in male Wistar Rats.

24 male Wistar rats weighing 250-300 g were randomly assigned into three groups including Sham, Ischemia/Control, and Ischemia/Exercise. The rats in the exercise groups ran on a rat treadmill for 45 minutes per day five days a week for 8 consecutive weeks. Common carotid artery occlusion procedure was employed for 45 minutes to induce ischemia. Cresyl violet (Nissl) was used to neuronal death, and ladder rung walking test was used to evaluate motor and functional recovery. In addition, NGF protein expression was assayed by immunohistochemistry.

Brain ischemia increased neuron death in CA1 region in hippocampus and impaired motor performance on the ladder rung task. In contrast, post-ischemic exercise considerably reduced neuron death and improved skilled motor performance. In addition, NGF protein expression was significantly higher in ischemic/exercise group than the ischemic/control group (P < 0.05).

When exercise is prescribed as a treatment and rehabilitation method after cerebral ischemia, it had significant effects on increasing NGF protein expression, and may reduce dead cells, and improve motor function.

Neurotrophic and growth factors are known to have positive effects on neuronal proliferation. However, findings on the effects of exercise training on these factors following brain stroke are limited. Thus, the aim of the present study was to investigate the effect of endurance training on gene expression of nerve growth factor (NGF) and fibroblast growth factor (FGF) in the hippocampus of rats after brain stroke.

Twenty and one adult male Wistar rats (weighing 210-252 gr) were purchased and randomly divided into three groups: control, stroke, and stroke+ training groups. Stroke was induced by the occlusion of both common carotid arteries (CCA) for 45 minutes. The rats in the training group were run on a treadmill at speeds ranging from 18 to 30 meters per minute for 20 to 50 minutes per session, 5 days a week for 8 weeks. Forty eight hours after the last training session, rats were sacrificed and gene expression of NGF and FGF in the hippocampus were measured with the Real Time-PCR technique.

In comparison to the control group, stroke led to a significant decrease in gene expression of NGF (p=0.0001) and FGF (p=0.0001). Also, after brain stroke, endurance training resulted in a significant increase in gene expression of NGF (p=0.001) and FGF (p=0.023) in the hippocampus of rats.

Based on the findings of this study, endurance training probably via up-regulation of neurotrophic and angiogenic factors could have therapeutic effects against ischemia-reperfusion induced injuries and decreased impairments induced by cerebral ischemia.

The brain is organ that has high adaptability in response to morphological, metabolic and functional to exercise and nutrition. The aim of this study was to examine the effect of omega-3 intake and aerobic training on nerve growth factor (NGF) in the hippocampus of healthy male rats and rats with homocysteine induced Alzheimer's model.
Ninety male Wistar rats (12 weeks old and mean weight 219.99 ± 12.60 g), were divided into 9 groups. To induce Alzheimer's disease, homocysteine was infused into the rats cerebroventricule at a dose of 0.6M were used. Aerobic training on a treadmill (5 days per week, with 50 to 55% of maximal oxygen consumption) were carried out and supplemented groups during the 8 weeks, daily 800 mg per kg body weight were administered omega-3 supplements. 72 hours after the last intervention session, the rats anesthetized, and surgically removed the hippocampus tissue. Data analysis using one way ANOVA and Tukey tests were performed (P Findings: In healthy subjects, intake of omega-3 caused a significant increase in NGF level (P = 0.001). Exercise training and absence of omega-3 along with exercise training, had no significant effect on NGF levels (P = 0.990 and P = 0.210 respectively). In subjects with Alzheimer's disease, aerobic training caused a significant increase in NGF levels (P = 0.020), and omega-3 intake with its combination with exercise training, had no significant change in the level of NGF (P = 0.930 and P = 0.220 respectively).
It seems that exercise training and omega-3 intake in the strategy of prevention and treatment of Alzheimer's disease can affect in many different forms.