جستجوی مقالات مرتبط با کلیدواژه « عامل نوروتروفیک مشتق از مغز (bdnf) » در نشریات گروه « پزشکی »

Binding of mature brain derived neurotrophic factor (BDNF) to tyrosine kinase B (TrkB) receptor leads to cell survival, while proBDNF binding to p75 receptor leads to cell death. Thus the aim of the present study was to investigate the effects of eight weeks pre-conditioning endurance training on BDNF, TrkB, proBDNF and p75 levels in the hippocampus male rats following ischemic reperfusion.

40 male wistar rats (12 weeks old and 236.56 ± 16.98g) were divided into four groups, including: ischemic control, ischemic training, healthy control, healthy training. Training groups (healthy and ischemic), trained with 30m/min (70% VO2max), 30min/day, and 5 days/week for 8 weeks on the treadmill. To induce ischemia (in ischemic groups), carotid artery is clamped with microsurgery clamp for 45 minutes. For data analysis, one-way ANOVA and post hoc Tukey tests were performed at a significance level of P ˂ 0.05.

The results showed that BDNF levels in hippocampus of ischemic control group were significantly lower than healthy control group (P = 0.001). Also BDNF levels in hippocampus of ischemic training group were higher than ischemic control group (P = 0.002). TrkB levels in control group were significantly lower than healthy control group (P = 0.026). But despite increasing in TrkB levels of ischemic training group than ischemic control group wasn’t significant (P = 0.556). proBDNF levels in ischemic control group were significantly higher than healthy control group (P = 0.001). No significant difference were found in proBDNF levels of ischemic training group than ischemic control (P = 0.418). No significant difference were found in p75 levels in difference were found in different group (P = 0.071).

Based on these results, it seems that pre-conditioning endurance training can have neuroprotective effect through improving BDNF, TrkB and proBDNF levels in hippocampus and can prevent apoptosis and neuronal death following ischemic reperfusion and can be studied as a complementary therapy in ischemic disease.

Brain derived neurotrophic factor (BDNF) have neuroprotective effect through binding with tyrosine kinase B (TrkB). Thus the Aim of the present study was to investigate the effects of eight weeks endurance training on BDNF and TrkB levels in the hippocampus of ischemic induced male rats.

40 Male wistar rats (12 weeks old and 228.19±21.18g) were divided into four groups, including: ischemic control, ischemic training, healthy control, healthy training. To induce ischemia, carotid artery is clamped with microsurgery clamp for 45 minutes. Training groups (healthy and ischemic), trained with 30m/min (70% VO2max), 30min/day, and 5 days/week on the treadmill. BDNF and TrkB levels of the hippocampus were measured using ELISA method.For data analysis, one-way ANOVA and post hoc Tukey tests were performed at a significance level of P˂0.05.

The results showed that BDNF levels in hippocampus of ischemic control group were significantly lower than healthy control and healthy training group (P values 0.001, 0.002 respectively). No significant differences were found between BDNF levels in ischemic training with ischemic control and healthy control group (p values 0.54, 0.091 respectively) and No significant differences were found between TrkB levels in ischemic control with healthy control and ischemic control group (p values 0.675, 0.821 respectively). TrkB level in healthy training group was significantly higher than healthy control, healthy training groups (P=0.001).

Based on these results, it seems that endurance training can have neuroprotective effect through increasing the level of BDNF and TrkB level in hippocampus of ischemic rats and can be studied as a complementary therapy in ischemic disease.

Behaviors and our lifestyles affect the expression of brain-derived neurotrophic factor (BDNF-Brain-Derived Neurotrophic Factor) and experiences with emotional health, such as exercise and enriched environment lead to increased levels of this neurotrophin. This study aimed to identify the possible effects of two different ways of training on levels of brain-derived neurotrophic factor (BDNF) in the hippocampus of adult male rats with a clearer focus on the role of exercise on modifying the synaptic plasticity.
In this experimental research, twenty-one Wistar rats were divided into three groups: (1) Control, (2) endurance training (ET), (3) high-intensity interval training (HIIT). ET group received 8-wk mild-intensity endurance exercise. The exercise schedule of HIIT group consisted of high intensity interval training for 8 weeks (with Active recovery). Hippocampal BDNF protein was assessed using commercial ELISA kits and the data were analyzed by one-way ANOVA. Statistical differences were considered significant at pFindings : The results showed that the ET group had no significant effect on BDNF protein level (p=0.735). In addition, HIIT group revealed no significant increase in BDNF protein level compared with the Control (p=0.070) and ET group (p=0.131).
Discussion & The results of the present study, do not show significant change in BDNF levels via exercise training, it seems that perform of HIIT training can increase amount of hippocampus BDNF protein level more than endurance training.

This study was to examine the effects of endurance training and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus. Twenty eight Wistar rats were divided into four groups: (1) Regular diet-sedentary (RD-Sed)، (2) Regular diet-Exercise (RD-Exe)، (3) HF-sedentary (HF-Sed)، and (4) HF- Exercise (HF- Exe); RD-Sed group was regarded as control. Animals in exercise groups received 8-wk endurance training and animals in HF groups were exposed to the HF diet for 8-wk. Hippocampal BDNF protein was assessed using commercial ELISA kits and the data were analyzed by one-way ANOVA. Statistical differences were considered significant at P<0. 05. The results showed that the endurance training had no significant increase in BDNF protein level comparison with the RD-Sd and HF-Sed groups; moreover the high-fat diet had no significant effect in BDNF protein level. According to results of present study، looks applications of endurance training can increase amount of hippocampus BDNF protein level.

This study was to examine the effects of endurance training and omega-3 supplementation in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus. Twenty eight Wistar rats were divided into four equal groups: control، exercise، diet، and exercise with diet Animals in the exercise group received 8 weeks of endurance training and animals in the diet group were treated with 100/mg/kg/day of omega-3 supplementation via oral gavage for 8weeks. The exercise with diet group received a combination of exercise and also supplementation. Hippocampal BDNF protein was assessed using commercial ELISA methods andthe data were analyzed by one-way ANOVA (p<0. 05). The results showed that BDNF level showed no significance increase in the exercise and diet alone groups.، Moreover، the diet and exercise group revealed a significant increase in BDNF level in comparison with the control and the exercise groups; but it was not significant compared with the diet group. The results of the present study suggest that concurrent administration of omega-3 diet and endurance training has an additive effect in the BDNF level in adult male rat hippocampus.