جستجوی مقالات مرتبط با کلیدواژه "نفروپاتی ماده حاجب" در نشریات گروه "پزشکی"

Contrast induced nephropathy (CIN) is one the complications resulting from coronary catheterization and is regarded as one of the reasons of acute kidney failure. Therefore، this study aimed to investigate the effect of ascorbic acid in the prevention of CIN in Yazd in 2012.

This study involves a double blind clinical trial in which 90 Diabetic patients with coronary catheterization have attended. The patients were divided randomly into two groups: control group and treatment group. Demographic and clinical data were collected by a questionnaire. Treatment group received vitamin C (2 grams) 2 hours before the intervention and the control groups were given 2 grams of the Placebo. The GFR (Glomerular filtration rate)، BUN (Blood Urea Nitrogen)، and Cr (Creatinin) were measured and compared after 2-3 days.

The CIN in treatment group was about 3 patients (7. 7%) and was 7 (16. 7%) in the control group. Thus، no significant difference was observed; though، there was a significant difference between Cr and GFR before and after the treatment in vitamin C group (PV= 0. 006، PV=0. 001)، but these differences were not significant in the placebo group. (PV=0. 661، PV=0. 747). Moreover، considering the participants’ age، sex and their primary function of kidney، a significant difference had not appeared due to the incidence of CIN between the two groups.

Our study did not show Ascorbic Acid effects in prevention of CIN in Diabetic patients.

Contrast-induced nephropathy (CIN) is most commonly defined as acute renal failure due to radiographic contrast medium exposure in patients undergoing cardiac cathetrization. In this study we investigated the possible association between volume expansions with N/S in prevention of contrast induced nephropathy. In this clinical trial study 962 patients، allocated in two groups underwent cardiac catheterization، in the first group with 575 patients، we used Normal Saline (N/S) (1-2 cc/kg/hr) but in the second group 387 patients did not use normal saline. We measured serum creatinin before and after Intervention and used T test and Man-Whitney test to analyze data. Mean Age of patients in the first group was 57. 8±10. 5 and in the second group was 57±10. 2 years، (p: 0. 212). Before catheterization Cr in the first group was 0. 94±0. 26 mg/dl and in the second group was 0. 98±0. 26mg/dl (p: 0. 04) that was a meaningful difference. After catheterization in the second group Cr was 1. 07±0. 26 mg/dl and in the first group was 1. 03±0. 30 mg/dl (p: 017) that was not a meaningful difference. Before and after catheterization serum Cr level difference in the first group was 0. 043±0. 44 and in the second group was 0. 132±0. 22 (p≤0. 01) that was meaningful. Based on this study we suggested that hydration with normal saline did not have a significant protective effect in renal performance، and it depends on gender and risk factors.