جستجوی مقالات مرتبط با کلیدواژه "ژانت سل گرانولوما" در نشریات گروه "پزشکی"

The present study aimed to evaluate vascular density in giant cell lesions with different biologic behavior. Therefore, CD34 expression in central and peripheral giant cell granulomas and the aneurysmal bone cyst was evaluated by immunohistochemistry.

A total of 15, 15, and 8 samples of PGCG, CGCG, and ABC were selected from the archives of the Dentistry School of Mashhad University and Ghaem Hospital, Mashhad, Iran, respectively. Immunohistochemical evaluation of CD34 expression was performed according to the manufacturer's instructions to assess microvessel density (MVD). MVD was calculated in five microscopic fields and the mean MVD of samples was evaluated. Findings were analyzed using t-test, ANOVA, and Pearson’s correlation coefficient.

CD34 expression was 31.53, 31, and 26.40 in CGCG, ABC, and PGCG samples, respectively. Although the highest MVD was in CGCGs, no statistical difference was observed between the studied groups (0.270).

According to the findings of the present study, evaluation of microvessel density with CD34 expression indicates no pathogenesis and different biological behavior of the studied groups. Therefore, further research seems necessary.

This study aimed to evaluate the Fibronectin expression in peripheral and central giant cell granulomas (PGCG and CGCG) of jaws and giant cell tumor (GCT) of bone using immunohistochemistry.

In this retrospective study, PGCG (n=15), CGCG (n=15), and GCT (n=10) samples were selected from the archives of Dental School and Ghaem Hospital, Mashhad, Iran. Distribution pattern, staining pattern, and intensity of Fibronectin expression in extracellular matrix were investigated using the immunohistochemistry method according to the manufacturer's instructions.

Regarding the intensity of expression, 26 (65%) samples showed strong expression. On the other hand, 64.3 % of the PGCG samples demonstrated weak expression, whereas 46.3% of the CGCG samples showed strong immunoreactivity. There was a statistically significant difference between PGCG and GCT in terms of strong and weak expression. Furthermore, the Reticulate-Fibrillar staining pattern was observed in 19 samples. The Reticulate-Fibrillar and Fibrillar in CGCG lesions and Reticular patternin PGCG lesions were the most prevalent patterns. A statistically significant correlation was reported between the staining pattern and the type of the lesion. The uniform distribution pattern was observed in 33 samples; in addition, it showed the most distribution in CGCG, and most cases of the focal distribution pattern were observed in the PGCG lesions. The distribution pattern was not related to the type of lesion.

The findings of the present study showed more similarity between CGCG and GCT lesions regarding Fibronectin immunoreactivity. Therefore, further studies are required to evaluate the similar pathogenesis of these lesions.

Peripheral and central giant-cell granulomas (PGCGs and CGCGs) and giant-cell tumor (GCT) of bone have similar histopathological features with different biological behavior. The aim of this study was to evaluate the expression of transforming growth factor beta (TGF-β) in these lesions by the help of immunohistochemistry.
In this study, 15 PGCGs, 15 CGCGs, and 10 GCTs were evaluated. The TGF-β immunoreactivity was assessed in mononuclear cells (MC) and multinucleated giant cells (MGC) of the studied groups. Data analysis was performed using Kruskal-Wallis and Dunn’s tests.
There was a significant difference between three studied groups regarding both MCs and MGCs. The highest mean of TGF-β immunostaining was observed in GCTs and the lowest in PGCGs. In pairwise comparison of the studied groups, a significant difference was observed between PGCGs and GCTs considering both MCs and MGCs. Additionally, a significant deference was reported only in MCs between CGCGs and GCTs.
The results may explain the different biological behavior and pathogenesis of these lesions despite the similarity of histopathologic features.

Irritation fibroma is a reactive lesion of the buccal mucosa that often occurs in line with the occlusal plane due to cheek biting. This lesion may also be seen on the palate، gingiva and lips; however، it mostly occurs in the areas exposed to trauma. This paper reports a case of extensive irritation fibroma on maxillary gingiva in a 36 year old male that was related to palatal margin of left premolars. The lesion was excised by biopsy and was diagnosed as irritation fibroma after histological analysis.

Excessive secretion of parathyroid hormone results in hyperparathyroidism which is classified into primary، secondary and tertiary categories. Tertiary hyperparathyroidism develops rarely in some patients with secondary hyperparathyroidism due to long-term and persistent renal disease and consequently autonomous hyperplasia or adenoma of one or more parathyroid glands. Classic triad signs of hyperparathyroidism، including renal stones، osseous changes and duodenal ulcers are also observed in this type. Sometimes giant cell granulomas of jaws are related to hyperparathyroidism. Case report: The patient was a 56-year-old female complaining of a prominent lesion in the left mandibular body. The medical history of the patient indicated chronic renal disease. Based on clinical، laboratory، radiographic and histopathological findings، a diagnosis of giant cell granuloma related to hyperparathyroidism was suggested. In secondary hyperparathyroidism that develops in renal patients or patients undergoing long-term dialysis، blood calcium levels are normal or below normal، but phosphorus and alkaline phosphatase levels increase. In tertiary hyperparathyroidism، similar to primary hyperparathyroidism، calcium and alkaline phosphatase levels increase but phosphorus levels decrease. In all types of hyperparathyroidism، osseous changes occur، the most significant of which is giant cell granuloma.

Peripheral giant cell granuloma or giant cell epulis is a relatively common reactive lesion of the oral mucosa in response to local irritation and trauma. It is mostly seen in women during the 4th to 6th decades of life. Since recurrence is relatively common surgery with extraction of the involved tooth or teeth and curettage of the alveolar bony socket is the preferable treatment. In children this lesion can occur after deciduous tooth root resorption and might have a more aggressive clinical course in this age group. Case report: Reported here is occurrence of a relatively common lesion in an uncommon age and sex group. A soft tissue lump in an asymptomatic, otherwise healthy, 10-year-old boy with no evidence of bone destruction was surgically excised and submitted for microscopic evaluation. Microscopically a diagnosis of peripheral giant cell granuloma was established. At 6-month follow-up the site of surgery had healed completely with no post-surgical complications. Discussion and Although peripheral giant cell granuloma is more common during the 4th to 6th decades of life, this lesion might occur in children, with alveolar bone resorption, abnormal patterns of eruption of permanent teeth and loose and displaced teeth. Therefore, the aim of this report was to draw attention to the possibility of the occurrence of these lesions at a young age to pave the way for early diagnosis and treatment.

Central giant cell granuloma formerly called «giant cell reparative granuloma،» is a non-neoplastic lesion. Some lesions demonstrate aggressive behaviors similar to that of a neoplasm. The mandibular / maxillary ratio has been reported as being from 2:1 to 3:1. Lesions are more common in the anterior portions of the jaws An 11-year old girl was referred with a chief complaint of chin expansion without pain. The radiographic exam ination showed a multilocular radiolucent lesion extended to lower border of the mandible. The histopathological examination showed a highly vascularized fibrous stroma with several multinucleated giant cells. Because of size of lesion، surgical approach was preferred. Most giant cell granulomas of the jaws are asymptomatic and usually first come to attention during a routine radiographic examination or as a result of painless expansion of the affected bone. So early diagnosis is very important in the prognosis.

Central giant cell granuloma is a tumor-like reactive lesion of the jaws، which is classified as aggressive and non-aggressive lesions. There are controversies about its pathogenesis، origin، histopathologic features and clinical behavior. The aim of this study was to investigate role of Src protein expression in the biologic behavior of giant cell granuloma. Paraffin-embedded tissues from 15 aggressive and 15 non-aggressive cases of central giant cell granuloma were assessed for the expression of Src using immunohistochemistry. In addition، a SID (staining-intensity distribution) score، proportion of stained cells×staining intensity، was evaluated for these lesions. Although no significant difference in Src expression and SID score was recognized between the clinical forms of central giant cell granuloma (p=0. 299 and p=0. 900، respectively)، a statistically significant correlation between them in both lesions was seen (p≤ 0. 002). The results of this study suggest an osteoclastic origin for the giant cells and imply that Src protein expression and its intensity is not a predictor of clinical behavior of these lesions.