جستجوی مقالات مرتبط با کلیدواژه "ژل پیروکسیکام" در نشریات گروه "پزشکی"

 Ankle injuries are among the most common musculoskeletal injuries in sports, accounting for 10% to 15% of all injuries. Since controlling pain and inflammation in ankle sprains is one of the main goals of treatment, we decided to compare the therapeutic effects of Cheleh daghi Herbal ointment with a common therapeutic gel such as piroxicam.

Methods & Materials:

 This study was performed as a double-blinded clinical trial for 6 months from January 2019 to August 2019. After referral, all patients completed the consent form, and the patientchr('39')s details and study variables were recorded by the evaluator in the research form. To measure joint inflammation, we measured the ankle with a meter tape in the ankle area (cm) and recorded. A goniometer was also used to measure the degree of ankle movements. The symptoms of ankle ecchymosis were also checked by physical examination and observation and recorded in the checklist. Statistical analysis was performed in SPSS V. 18 using statistical tests (the Mann-Whitney U test, the Chi-square, and the independent t-test).

Ethical Considerations: 

The Research Ethics Committee of Arak University of Medical Sciences approved the study (Code: IR.ARAKMU.REC.1396.55) and registered by the Clinical Trial (Code: IRCT2017071720258N53).

The Mean±SD age in the control group was 34.2±8.6 years, and in the case group was 35.4±8.9 years. There was no statistically significant difference according to the Mann-Whitney U test (P<0.05). Also, the Mean±SD height in the control group was 1.7±0.12 m and in the case group was 1.72±0.11 m. The results also showed a statistically significant difference between the two groups studied before and after the intervention regarding the mean indicators of pain, swelling, and inflammation around the joints (P<0.05).

 The results of our study showed that Cheleh daghi Herbal ointment for 3 weeks could be more effective in reducing local pain and inflammation than piroxicam gel treatment.

Knee osteoarthritis is the most common cause of disability in many societies. Therapeutic measures such as using anti-inflammation drugs and physiotherapy programs have been used to suppress knee pain and improve knee joint function in patients with knee osteoarthritis. The aim of this study was to compare the effects of iontophoresis of piroxicam gel, galvanic current with or without piroxicam gel on pain, functional ability and knee muscle strength in patients with knee osteoarthritis. This study was a clinical trial conducted in Akhtar hospital. Forty two female patients (mean age 58.52 years old) with knee osteoarthritis participated in this study. The protocol was performed in Physiotherapy Clinic of Mazandaran Medical University, Mazandaran, Iran. All patients were randomly assigned to three groups. Iontophoresis of piroxicam gel was applied for group 1 (n=14), proxicam gel for group 2 (n=14) and galvanic current for group 3 (n=14). The procedure was carried out for 20-minutes, three times a week and for two following weeks. Knee pain and functional ability were estimated by knee injury and osteoarthritis outcome score (KOOS) questioner and the strength of knee extensor and flexor muscles by an isometric device just before the first treatment and immediately after the last treatment times. A significant decrease in pain and a significant increase in functional ability and the strength of knee extensor muscles were resulted in all studied groups (P < 0.05). According to ANOVA test, the level of the percentage difference which was computed for KOOS and knee muscle strength before and after treatments was significantly higher in group 1 than the other two (P < 0.01). Pain and knee functional ability were significantly improved in patients in all three methods. But iontophoresis of piroxicam gel appeared to be more effective in relieving pain and improving knee functional abilities than the application of galvanic current or piroxicam gel alone. Iontophoresis facilitated the transmission of piroxicam gel through the skin.

Fractional Co2 laser is a good procedure to treat acne scar, surgical scar and senile wrinkles but it is almost painful and if we provide a good pain relief the patient will have a good cooperation during laser, so we can use higher fluence with better results. To determine the safety and efficacy of piroxicam gel in the control of pain and erythema caused by fractional Co2 laser compared with lubricant gel. In this clinical trial we chose 122 patients who refered to Novin laser clinic for fractional Co2 laser. The patients used gel A (piroxicam gel) on one side of the face and gel B (lubricant gel) on the other side of the face as placebo an hour before laser. To determine pain level we used VAS (Visual analogue scale) score from one point to ten. Each patient scored the pain during, immediately after, 1 hour later and 24 hours after laser. To determine the severity of erythema during, immediately after, 1 hour later and one week after laser we compared the erythema of both side of the face with each other. We also compare the prevalence of Post-inflammatory pigmentation (PIP) after 1 month of laser with both gels. At the end we analyzed the data with SPSS18. Piroxicam gel can provide better pain relief during laser, immediately after laser and 1 hour later compared with lubricant gel but pain score was the same 24 hours later with both gels. The severity of erythema with both gels was the same during laser, immediately after, 1 hour later and after one week. In fact piroxicam gel has no effect on the erythema caused by fractional Co2 laser.The prevalence of PIP was the same for both gels after one month so piroxicam gel can not prevent PIP caused by fractional Co2 laser. As a result piroxicam gel can use as a safe and effective drug before fractional Co2 laser to decrease the pain but has no effect on erythema and PIP caused by fractional Co2 laser.